Role and research progress of ferroptosis in colorectal cancer

doi:10.3760/cma.j.cn371439-20250328-00054

Abstract

Abstract:

Colorectal cancer （CRC） is one of the most prevalent malignant tumors of the digestive system worldwide， characterized by continuously rising incidence and mortality rates. Despite significant advancements in therapeutic approaches， the prognosis for advanced-stage CRC remains unsatisfactory， highlighting the urgent need to explore novel molecular mechanisms and therapeutic strategies. Ferroptosis， a form of programmed cell death driven by iron-dependent lipid peroxidation， plays a crucial role in cancer occurrence， progression， and treatment resistance. Activation of ferroptosis significantly suppresses tumor cell growth. Further investigation into the mechanisms of ferroptosis in CRC occurrence， progression， and treatment could provide valuable insights for both basic and clinical research on CRC.

Key words: Colorectal neoplasms, Ferroptosis, Antineoplastic protocols, Ferroptosis-related gene

Guo Haiyang, Hong Yonggang, Hao Liqiang. Role and research progress of ferroptosis in colorectal cancer[J]. Journal of International Oncology, 2025, 52(5): 319-324.

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