Journal of International Oncology ›› 2024, Vol. 51 ›› Issue (6): 370-375.doi: 10.3760/cma.j.cn371439-20231213-00064

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Research progress of colorectal cancer risk assessment models based on FIT and gut microbiota

Zhang Rui1, Chu Yanliu2()   

  1. 1School of Clinical Medicine, Shandong Second Medical University, Weifang 261000, China
    3Department of Gastroenterology, Weihai Municipal Hospital Affiliated to Shandong University, Weihai 264200, China
  • Received:2023-12-13 Revised:2024-01-16 Online:2024-06-08 Published:2024-06-28
  • Contact: Chu Yanliu, Email: yyy6306@126.com
  • Supported by:
    Clinical Research Project of Shandong University(2020SDUCRCA012)

Abstract:

Colorectal cancer risk assessment model is an important method to identify high-risk groups of colorectal cancer in colorectal cancer screening. In recent years, fecal immunochemical test (FIT) and gut microbiota have become research hotspots. Domestic and foreign scholars have established a variety of colorectal cancer risk assessment models based on FIT and gut microbiota, including colorectal cancer risk assessment models based on FIT, colorectal cancer risk assessment models based on gut microbiota, and colorectal cancer risk assessment models based on FIT and gut microbiota. The above assessment models are helpful for colorectal cancer screening and early diagnosis and treatment. Among the existing assessment models, the FIT combined with gut microbiota assessment model has shown a high diagnostic efficiency for colorectal cancer, which is expected to become a valuable non-invasive screening method for colorectal cancer.

Key words: Colorectal neoplasms, Feces, Occult blood, Gastrointestinal microbiome, Risk assessment