Journal of International Oncology ›› 2023, Vol. 50 ›› Issue (7): 432-436.doi: 10.3760/cma.j.cn371439-20230413-00083

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Gut microbiome and tumor immunotherapy

Guo Ciliang1,2, Jiang Chunping1,2, Wu Junhua1,2()   

  1. 1Medical School of Nanjing University,Nanjing 210008,China
    2Jinan Microecological Biomedicine Shandong Laboratory,Jinan 250022,China
  • Received:2023-04-13 Revised:2023-06-13 Online:2023-07-08 Published:2023-08-03
  • Contact: Wu Junhua,Email: wujunhua@nju.edu.cn
  • Supported by:
    National Natural Science Foundation of China(81972888);Jinan Microecological Biomedicine Shandong Laboratory Research Project(JNL202219B);Jinan Microecological Biomedicine Shandong Laboratory Research Project(JNL202204A)

Abstract:

Neoplasms immunotherapy has made a major breakthrough in the clinical practice of refractory tumor. However,there are still individual differences in treatment results and drug resistance in clinical application. Gastrointestinal microbiome is gradually recognized as an immunoregulatory factor in recent years,and more and more studies have focused on its influences on the efficacy of tumor immunotherapy. Targeting gastrointestinal microbiota to improve the response of tumor patients to immunotherapy has potential clinical application value.

Key words: Neoplasms, Immunotherapy, Gastrointestinal microbiome, Immune checkpoint inhibitors