Journal of International Oncology ›› 2017, Vol. 44 ›› Issue (6): 460-.doi: 10.3760/cma.j.issn.1673-422X.2017.06.015
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Liu Zhongzheng, Xie Xiaodong
Online:
2017-06-08
Published:
2017-06-16
Contact:
Xie Xiaodong
E-mail:doctor_xxd@163.com
Liu Zhongzheng, Xie Xiaodong. Adverse reactions of the new generation of tumor immunotherapy and its management strategy[J]. Journal of International Oncology, 2017, 44(6): 460-.
[1] CouzinFrankel J. Breakthrough of the year 2013. Cancer immunotherapy[J]. Science, 2013, 342(6165): 1432-1433. DOI: 10.1126/science.342.6165.1432. [2] 张淑娟, 常建华. 肺癌的免疫治疗[J]. 国际肿瘤学杂志, 2015, 42(10): 776-779. DOI: 10.3760/cma.j.issn.1673422X.2015.10.016. [3] Ledford H. Melanoma drug wins US approval[J]. Nature, 2011, 471(7340): 561. DOI: 10.1038/471561a. [4] Poole RM. Pembrolizumab: first global approval[J]. Drugs, 2014, 74(16): 1973-1981. DOI: 10.1007/s4026501403145. [5] Kazandjian D, Suzman DL, Blumenthal G, et al. FDA approval summary: nivolumab for the treatment of metastatic nonsmall cell lung cancer with progression on or after platinumbased chemotherapy[J]. Oncologist, 2016, 21(5): 634-642. DOI: 10.1634/theoncologist.20150507. [6] Raedler LA. Opdivo (Nivolumab): second PD1 inhibitor receives FDA approval for unresectable or metastatic melanoma[J]. Am Health Drug Benefits, 2015, 8(Spec Feature): 180-183. [7] Markham A. Atezolizumab: first global approval[J]. Drugs, 2016, 76(12): 1227-1232. DOI: 10.1007/s4026501606188. [8] Markham A. Elotuzumab: first global approval[J]. Drugs, 2016, 76(3): 397-403. DOI: 10.1007/s4026501605400. [9] Weber J, Thompson JA, Hamid O, et al. A randomized, doubleblind, placebocontrolled, phase Ⅱ study comparing the tolerability and efficacy of ipilimumab administered with or without prophylactic budesonide in patients with unresectable stage Ⅲ or Ⅳ melanoma[J]. Clin Cancer Res, 2009, 15(17): 5591-5598. DOI: 10.1158/10780432.CCR091024. [10] Robert C, Thomas L, Bondarenko I, et al. Ipilimumab plus dacarbazine for previously untreated metastatic melanoma[J]. N Engl J Med, 2011, 364(26): 2517-2526. DOI: 10.1056/NEJMoa1104621. [11] Lynch TJ, Bondarenko I, Luft A, et al. Ipilimumab in combination with paclitaxel and carboplatin as firstline treatment in stage ⅢB/Ⅳ nonsmallcell lung cancer: results from a randomized, doubleblind, multicenter phase Ⅱ study[J]. J Clin Oncol, 2012, 30(17): 2046-2054. DOI: 10.1200/JCO.2011.38.4032. [12] Kwon ED, Drake CG, Scher HI, et al. Ipilimumab versus placebo after radiotherapy in patients with metastatic castrationresistant prostate cancer that had progressed after docetaxel chemotherapy (CA184043): a multicentre, randomised, doubleblind, phase 3 trial[J]. Lancet Oncol, 2014, 15(7): 700-712. DOI: 10.1016/S14702045(14)701895. [13] Lebbé C, Weber JS, Maio M, et al. Survival followup and ipilimumab retreatment of patients with advanced melanoma who received ipilimumab in prior phase Ⅱ studies[J]. Ann Oncol, 2014, 25(11): 2277-2284. DOI: 10.1093/annonc/mdu441. [14] Ribas A, Puzanov I, Dummer R, et al. Pembrolizumab versus investigatorchoice chemotherapy for ipilimumabrefractory melanoma (KEYNOTE002): a randomised, controlled, phase 2 trial[J]. Lancet Oncol, 2015, 16(8): 908-918. DOI: 10.1016/S14702045(15)000832. [15] Herbst RS, Baas P, Kim DW, et al. Pembrolizumab versus docetaxel for previously treated, PDL1positive, advanced nonsmallcell lung cancer (KEYNOTE010): a randomised controlled trial[J]. Lancet, 2016, 387(10027): 1540-1550. DOI: 10.1016/S01406736(15)012817. [16] Robert C, Schachter J, Long GV, et al. Pembrolizumab versus ipilimumab in advanced melanoma[J]. N Engl J Med, 2015, 372(26): 2521-2532. DOI: 10.1056/NEJMoa1503093. [17] Ribas A, Hamid O, Daud A, et al. Association of pembrolizumab with tumor response and survival among patients with advanced melanoma[J]. JAMA, 2016, 315(15): 1600-1609. DOI: 10.1001/jama.2016.4059. [18] Weber JS, D′angelo SP, Minor D, et al. Nivolumab versus chemotherapy in patients with advanced melanoma who progressed after antiCTLA4 treatment (CheckMate 037): a randomised, controlled, openlabel, phase 3 trial[J]. Lancet Oncol, 2015, 16(4): 375-384. DOI: 10.1016/S14702045(15)700768. [19] Rizvi NA, Mazières J,Planchard D, et al. Activity and safety of nivolumab, an antiPD1 immune checkpoint inhibitor, for patients with advanced, refractory squamous nonsmallcell lung cancer (CheckMate 063): a phase 2, singlearm trial[J]. Lancet Oncol, 2015, 16(3): 257-265. DOI: 10.1016/S14702045(15)700549. [20] Motzer RJ, Rini BI, Mcdermott DF, et al. Nivolumab for metastatic renal cell carcinoma: results of a randomized phase Ⅱ trial[J]. J Clin Oncol, 2015, 33(13): 1430-1437. DOI: 10.1200/JCO.2014.59.0703. [21] Brahmer J, Reckamp KL, Baas P, et al. Nivolumab versus docetaxel in advanced squamouscell nonsmallcell lung cancer[J]. N Engl J Med, 2015, 373(2): 123-135. DOI: 10.1056/NEJMoa1504627. [22] Lacouture ME, Wolchok JD, Yosipovitch G, et al. Ipilimumab in patients with cancer and the management of dermatologic adverse events[J]. J Am Acad Dermatol, 2014, 71(1): 161-169. DOI: 10.1016/j.jaad.2014.02.035. [23] Klein O, Ebert LM, Nicholaou T, et al. MelanAspecific cytotoxic T cells are associated with tumor regression and autoimmunity following treatment with antiCTLA4[J]. Clin Cancer Res, 2009, 15(7): 2507-2513. DOI: 10.1158/10780432.CCR082424. [24] Cheng R, Cooper A, Kench J, et al. Ipilimumabinduced toxicities and the gastroenterologist[J]. J Gastroenterol Hepatol, 2015, 30(4): 657-666. DOI: 10.1111/jgh.12888. [25] Ryder M, Callahan M, Postow MA, et al. Endocrinerelated adverse events following ipilimumab in patients with advanced melanoma: a comprehensive retrospective review from a single institution[J]. Endocr Relat Cancer, 2014, 21(2): 371-381. DOI: 10.1530/ERC130499. [26] Kim KW, Ramaiya NH, Krajewski KM, et al. Ipilimumab associated hepatitis: imaging and clinicopathologicfindings[J]. Invest New Drugs, 2013, 31(4): 1071-1077. DOI: 10.1007/s1063701399396. [27] Marrone KA, Ying W, Naidoo J. Immunerelated adverse events from immune checkpoint inhibitors[J]. Clin Pharmacol Ther, 2016, 100(3): 242-251. DOI: 10.1002/cpt.394. [28] Choi JN. Dermatologic adverse events to chemotherapeutic agents, Part 2: BRAF inhibitors, MEK inhibitors, and ipilimumab[J]. Semin Cutan Med Surg, 2014, 33(1): 40-48. [29] Nancey S, Boschetti G, Cotte E, et al. Blockade of cytotoxic Tlymphocyte antigen4 by ipilimumab is associated with a profound longlasting depletion of Foxp3+ regulatory T cells: a mechanistic explanation for ipilimumabinduced severe enterocolitis?[J]. Inflamm Bowel Dis, 2012, 18(8): E1598-E1600. DOI: 10.1002/ibd.21927. [30] Tarhini A. Immunemediated adverse events associated with ipilimumab ctla4 blockade therapy: the underlying mechanisms and clinical management[J]. Scientifica(Cairo), 2013, 2013: 857519. DOI: 10.1155/2013/857519. |
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