Journal of International Oncology ›› 2024, Vol. 51 ›› Issue (3): 175-180.doi: 10.3760/cma.j.cn371439-20231109-00028

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Advances in predicting efficacy and prognostic markers of immunotherapy for gastric cancer

Liu Yulan1,2, Jing Haiyan3, Sun Jing1, Song Wei2, Sha Dan2()   

  1. 1Second Clinical Medical College of Shandong University of Traditional Chinese Medicine, Jinan 250355, China
    2Department of Minimally Invasive Comprehensive Treatment to Cancer, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, China
    3Department of Pathology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, China
  • Received:2023-11-09 Revised:2023-12-04 Online:2024-03-08 Published:2024-04-10
  • Contact: Sha Dan, Email: shadan@sdfmu.edu.cn
  • Supported by:
    Natural Science Foundation of Shandong Province of China(ZR2021MH140);Science and Technology Innovation Development Program of Jinan City of Shandong Province(202019085)

Abstract:

The high intra- and inter-tumor heterogeneity of gastric cancer leads to a great difference in the immunotherapy efficacy and the prognosis among patients. Several biomarkers, including programmed death-ligand 1, human epidermal growth factor receptor 2, the features of tumor microenvironment, the peripheral blood inflammatory markers and Claudin18.2 have predictive value in the immunotherapy efficacy and the prognosis of gastric cancer patients, which might help the clinicians find the potential patients who will benefit from immunotherapy, and achieve the goal of precision medicine.

Key words: Stomach neoplasms, Immunotherapy, Forecasting, Biomarkers, tumor, Prognosis