Research progress of CAR-T in the treatment of esophageal squamous cell carcinoma

doi:10.3760/cma.j.cn371439-20221123-00045

Abstract

Abstract:

Chimeric antigen receptor T cell （CAR-T） therapy， an emerging immunotherapy， has achieved remarkable results in the treatment of hematologic tumors. However， it's limited in the treatment of solid tumors such as esophageal squamous cell carcinoma due to various factors. Clarifying the reasons for the limitation of CAR-T therapy and exploring the corresponding solutions can provide new ideas and insights for the treatment of esophageal squamous cell carcinoma.

Key words: Esophageal squamous cell carcinoma, Receptors, chimeric antigen, Tumor microenvironment, Immunotherapy

Ding Hao, Ying Jintao, Fu Maoyong. Research progress of CAR-T in the treatment of esophageal squamous cell carcinoma[J]. Journal of International Oncology, 2023, 50(4): 231-235.

Figures/Tables 1

References 45

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注册号	临床试验名称	靶点	研究机构	开始日期	状态
NCT03638206^[28]	Ⅰ~Ⅱ期临床研究，多靶点基因修饰CAR-T治疗食管癌的安全性和有效性	NY-ESO-1	郑州大学第一附属医院	2018.3.1	招募中
NCT05396300^[29]	Ⅰ期临床研究，评估CAR-T在晚期食管癌患者中的安全性和耐受性	CEA	浙江大学第一附属医院	2022.5.25	招募中
NCT05415475^[30]	Ⅰ期临床研究，验证CAR-T治疗晚期食管癌的安全性和有效性	CEA	山东省第二人民医院	2021.9.10	招募中
NCT05538195^[31]	Ⅰ~Ⅱ期临床研究，评估CAR-T治疗食管癌的安全性和有效性	CEA	河南省肿瘤医院	2022.6.7	招募中
NCT03013712^[32]	Ⅰ~Ⅱ期临床研究，评估CAR-T治疗食管癌的安全性和有效性	EpCAM	成都医学院	2017.1.6	招募中
NCT03706326^[33]	Ⅰ~Ⅱ期临床研究，评估CAR-T治疗食管癌患者的安全性和有效性	MUC1	广东药科大学附属医院	2018.9.28	招募中