Role of sodium hydrogen exchanger isoform 1 in tumor microenvironment

doi:10.3760/cma.j.issn.1673422X.2017.03.012

Abstract

Abstract: The reversed pH gradient across the cell membrane on account of intracellular alkalinization and extracellular acidosis is an importart characteristic of tumor microenvironment. Sodium hydrogen exchanger isoform 1 (NHE1) is ubiquitously expressed at the plasma membrane of many types of cells, which plays a critical role in intracellular pH and cell volume homeostasis. NHE1 plays an important role in the regulation of tumor microenvironment and involves in tumor migration and invasion, which may be a potential new target in anticancer therapy.

Key words: Acidbase equilibrium, Neoplasm invasiveness, Cell movement, Tumor microenvironment, Sodium hydrogen exchanger isoform 1

Wang Wei, Yang Xuejun. Role of sodium hydrogen exchanger isoform 1 in tumor microenvironment[J]. Journal of International Oncology, 2017, 44(3): 205-208.

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