Journal of International Oncology ›› 2017, Vol. 44 ›› Issue (3): 201-204.doi: 10.3760/cma.j.issn.1673422X.2017.03.011

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Function of Cystatin SN and its relationship with tumors

Jiang Shanshan, Xin Ya   

  1.  Laboratory of Gastrointestinal OncoPathology of Cancer Institute and General Surgery Institute, First Affiliated Hospital of China Medical University, Shenyang 110001, China
  • Online:2017-03-08 Published:2017-02-28
  • Contact: Xin Yan E-mail:yxin@mail.cmu.edu.cn
  • Supported by:

     National Natural Science Foundation of

    China (81071650, 30973503); Special Foundation for Science and Technology

    Program in Liaoning Province of China (2013225303103, 20114040133)

Abstract:   Cysteine protease inhibitor SN (Cystatin SN) is a secretory protein encoded by CST1, with the promotion of cell senescence and apoptosis activity, playing an important role in the regulation of proteolytic activity. Many studies have found that Cystatin SN is abnormally expressed in various kinds of tumors, and is closely related with the tumorigenesis and progression. Cystatin SN may play an important role in the diagnosis and prognosis of tumors.

Key words: Cysteine proteinase inhibitors, Neoplasms, Function