Journal of International Oncology ›› 2023, Vol. 50 ›› Issue (2): 122-125.doi: 10.3760/cma.j.cn371439-20221024-00025

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Research status and application prospect of a novel immune checkpoint TIGIT in the immunotherapy of multiple myeloma

Zhang Yuxiao, Zhang Liansheng(), Li Lijuan()   

  1. Department of Hematology,Lanzhou University Second Hospital,Lanzhou 730000,China
  • Received:2022-10-24 Revised:2022-12-12 Online:2023-02-08 Published:2023-03-22
  • Contact: Zhang Liansheng,Email:zhanglsh@lzu.edu.cn;Li Lijuan,Email:doctorjuan@sina.com
  • Supported by:
    National Clinical Medical Research Center for Hematological Diseases Subject of Commission(2021WWA01);Cuiying Scientific and Technological Innovation Program of Lanzhou University Second Hospital(CY2017-ZD04);Cuiying Scientific and Technological Innovation Program of Lanzhou University Second Hospital(CY2019-MS14)

Abstract:

T cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domain (TIGIT) is a new immune checkpoint protein. Studies have shown that TIGIT can cause dysfunction of immune cells,weaken the anti-tumor effect,thus leading to tumor immune tolerance and immune escape. Blocking TIGIT can reverse immune cell failure and exert anti-tumor effect,which is expected to become a new therapeutic target for multiple myeloma.

Key words: Multiple myeloma, Immunotherapy, TIGIT