Table of Content

08 June 2013, Volume 40 Issue 6 Previous Issue    Next Issue

For Selected:

Download Citations EndNote Reference Manager ProCite BibTeX RefWorks

Toggle Thumbnails

Multidrug resistance mediated by ABCG2 SHEN Fei, CHEN Bao-An 2013, 40 (6):  403-406.  Abstract ( 445 )   PDF (756KB) ( 1540 )   Save ABCG2 is a member of the ATP-binding cassette (ABC) transporter family. The overexpression of ABCG2 is identified as one of the important mechanisms that limiting cellular accumulation of various compounds. With regard to its broad substrate spectrum including various anticancer drugs and environmental carcinogens, the function of ABCG2 is associated with multidrug resistance (MDR) and tumor development. ABCG2 as a target site to reverse MDR has been widely concered. Related Articles | Metrics

Oncogene Pim-1 and Tumor XU Jia-Jie, WANG Ke-Jing, GE Ming-Hua 2013, 40 (6):  406-409.  Abstract ( 737 )   PDF (677KB) ( 1560 )   Save Oncogene Pim-1 has a close relationship with the occurrence and development of several tumours. It is involved in a number of signal transduction pathways and regulates the expression of the downstream biological factors or acts synergistically with other oncogenes. Pim-1 plays an important role in the clinical diagnosis, treatment and prognosis of some tumors, and provides a new potential target in the chemotherapy of tumors. Recently, Pim-1-targeting treatment strategy has be a research hotspot and it would be used for cancer clinical treatment hopefully. Related Articles | Metrics

Targeting regulatory T cells and immunotherapy of tumor ZHAO Gang, SU Qing, LI Jing, LIU Ai-Qin 2013, 40 (6):  409-412.  Abstract ( 588 )   PDF (679KB) ( 1602 )   Save Regulatory T cells (Tregs) possess the function of immune suppression and achieve immunosuppression by the approach of expressing cytotoxic T lymphocyte-associated antigen, perforin-particle enzyme mediated cytotoxic effect, and secretion of cytokines such as IL-10, TGF-β, et al. The antibodies, vaccines and chemical drugs can be applied for targeting FOXP3+CD25+CD4+Tregs, depleting Tregs in peripheral blood and tumor tissues of patients of various forms of cancers. The function of immune suppression can be decreased and antitumor curative effects by immunotherapy can be enhanced. Related Articles | Metrics

Animal models of cancer metastasis LIU Jun, CUI Shu-Xiang 2013, 40 (6):  412-415.  Abstract ( 666 )   PDF (677KB) ( 2019 )   Save Animal models using for research the cancer matestasis should be entirely similar to the clinical pathological process in patients. Currently, two kinds of animal models with genetic engineering and human tumor xenografts are available in laboratory, which provide a possible research tool to investigate the mechanism of tumor metastasis and explore the experimental treatment. In these models, the techniques including how to select the cell lines and using real-time imaging detection are very important factors. Related Articles | Metrics

Research of hypoxia-inducible factor contribute to tumor angiogenesis SUI Wen-Wen, ZHANG Wei-Dong 2013, 40 (6):  416-418.  Abstract ( 627 )   PDF (671KB) ( 1760 )   Save Department of Pathology, Institute of Basic Medicine, Shandong Academy of Medical Sciences; School of Medicine and Life Sciences, University of Jinan- Shandong Academy of Medical Sciences, Jinan 250062, China Related Articles | Metrics

MicroRNA-203 and cancer QI Qiu-Feng, LIU Yong-Ping 2013, 40 (6):  419-421.  Abstract ( 711 )   PDF (668KB) ( 1537 )   Save MicroRNA(miRNA)-203 is a stemness-inhibiting miRNA that adjusts the epithelioid cell differentiation by restricting the expression of stemness-related transcription factor. Its abnormal expression has been detected in several types of human cancers, including bladder cancer, breast cancer, colon cancer and pancreatic cancer. MiRNA-203 plays a critical role in the tumor genesis and development by regulating cell proliferation, differentiation and apoptosis. Related Articles | Metrics

The role and relation of STAT3 and epithelial-mesenchymal transition in tumor cells LI Xu, ZOU Xiao-Ping 2013, 40 (6):  422-424.  Abstract ( 614 )   PDF (669KB) ( 1493 )   Save STAT3 can be activated by various cytokines and participate in the process of tumor cells proliferation, angiogenesis, invasion and chemotherapy resistance. Epithelial-mesenchymal transition (EMT) also plays an important role in the process of tumor invasion and metastasis and chemotherapy resistance. Studies have shown that STAT3 can regulate the process of EMT so as to change the invasion and metastasis abilities of tumor cells, and to enhance their ability of  chemotherapy resistance. Discussion of the role and relation of STAT3 and EMT in tumor cells will be helpful to provide reliable theory for tumor molecular targeted therapy. Related Articles | Metrics

Peroxisome proliferator-activated receptor gamma and epithelial-mesenchymal transition in cancer GAO Chao, FENG Xiang-Ying 2013, 40 (6):  425-428.  Abstract ( 758 )   PDF (678KB) ( 1434 )   Save Epithelial-mesenchymal transition (EMT) of cancer can enhance the abilities of invasion and metastasis of cancer cells, which is one of the reasons for treatment failure. Peroxisome proliferator-activated receptor gamma (PPARγ) is an important regulatory factor in EMT of cancer cells. Recent researches show that activation of PPARγ plays a role in the occurrence and development of EMT by regulating the E-cadherin, Smad complex and body microenvironment. Therefore, in-depth research for the relationship among PPARγ, EMT and cancer is expected to provide a new direction for tumor treatment. Related Articles | Metrics

The immunosuppression mechanism of MDSC and regulatory T cells in inflammation and tumor microenvironment ZHAO Jin-Quan, WANG Jian-Song, ZHAN Hui 2013, 40 (6):  428-431.  Abstract ( 624 )   PDF (680KB) ( 1719 )   Save Myeloid-derived suppressor cells (MDSCs) and regulatory T cell (Treg) in the tumor microenvironment are important inhibitory immune cells. Research finds that MDSC and Treg increase in large number under the conditions of inflammation, infection and cancer and are able to suppress the immunity system and promote tumor-cell invasion and metastasis through multiple mechanisms. Finding the causes of resulting in the increase of MDSCs and Treg in tumor microenvironment and the eliminating methods have become new focuses in the field of anti-tumor immunotherapy. Related Articles | Metrics

Chemokine receptor CXCR7 and tumor WANG Na-Na, ZHI Yu, BAI Ying 2013, 40 (6):  431-433.  Abstract ( 565 )   PDF (672KB) ( 1547 )   Save CXCR7 is a new receptor of chemokine CXCL12 after CXCR4. The present study shows that CXCL12/CXCR7 biological axis has important influence to the  development of a variety of tumors, similar to CXCL12/CXCR4 biological axis. CXCR7 is present in many kinds of tumor tissues and tumor cells widely, and plays an important role in tumor cells growth, proliferation, adhesion and migration. Restraining CXCR7 expression or blocking the CXCR7 signaling pathways may offer new strategies for the treatment of tumors. Related Articles | Metrics

Notch signaling pathway and glioma stem cell niche LIN Cai-Hou, ZHENG Zong-Qing, QIU Xian-Xin, LIN Zhi-Xiong 2013, 40 (6):  434-436.  Abstract ( 678 )   PDF (671KB) ( 1628 )   Save A small fraction of tumor stem cells exist in glioma and play a key role in the tumorigenesis and propagation of glioma. They have a close relationship with their niche that offers structural and functional support. In glioma niche, vascular endothelial cells can provide Notch ligands for cancer stem cells to activate Notch pathway and contact with other signaling pathways, maintaining the tumor stem cell self-renewal and increasing resistance of brain tumor stem cells to radiotherapy. Therefore, Notch signaling pathway is considered to be a new therapeutic target of glioma. Related Articles | Metrics

Radiotherapy of brain metastases WANG Zhi-Fen, QIAO Xue-Ying 2013, 40 (6):  437-440.  Abstract ( 634 )   PDF (679KB) ( 1554 )   Save Brain metastases is a common cause of advanced tumors teeatment failure, and radiotherapy is one of the main treatment modalities. With the development of radiotherapy techniques, the survival and quality of life of patients with brain metastases have been significantly improved. Whole brain radiotherapy, stereotactic radiotherapy as well as the combination are the main treatment options，but the best fraction size, the most optional time and suitable patients need to be further investigated. Novel radiotherapy techniques such as simultaneous integrated boost have been a research hotspot. Related Articles | Metrics

Research of the epilepsy induced by glioma ZHANG Chi, ZHANG Cong, ZHANG Jing-Jun 2013, 40 (6):  440-443.  Abstract ( 648 )   PDF (680KB) ( 1398 )   Save Glioma is the most frequent type of intracranial tumors, which is always associated with seizures. The type, location and pathological grade of glioma is closely related to incidence and efficacy of epilepsy. Recent research shows that glioma and the factors around glioma may effect on the excitation and inhibition system of brain. The pathogenesis of epilepsy remains to be studied. Related Articles | Metrics

The application of 18F-FDG PET-CT in nasopharyngeal carcinoma SU Yan-Xia, HAO Jun-Fang 2013, 40 (6):  443-447.  Abstract ( 601 )   PDF (690KB) ( 1451 )   Save The application of 18F-FDG PET-CT in the diagnosis and treatment of nasopharyngeal carcinoma includes early diagnosis, clinical staging, contouring target volume, predicting the sensitivity of tumors to radiotherapy and effect evaluation, and monitoring the residual and recurrence. However, 18F-FDG uptake of tumor cells is under the influence of various factors, so false positive and false negative are unavoidable. Therefore it is need to develop more specific tracer agent in order to improve the accuracy of diagnosis and treatment, as well as to carry out multicenter clinical trial to identify the correlation of standardized uptake value （SUV） and radiation target volume. Related Articles | Metrics

Influencing factors of quality of life in patients with lung cancer JIN Hui, LIU Wei 2013, 40 (6):  447-449.  Abstract ( 618 )   PDF (725KB) ( 1360 )   Save Clinical studies show that the factors that impact the quality of life (QOL) in patients with lung cancer are comprehensive. Physiological factors include breathing difficulties, cancer-related fatigue. Depression, anxiety and other psychological factors also play a major role. Social and family support is also crucial to improve the QOL in patients with lung cancer. Related Articles | Metrics

Progress of microRNAs in regulating drug resistance of breast cancer WANG Xue-Mei, LU Dan 2013, 40 (6):  449-452.  Abstract ( 557 )   PDF (678KB) ( 1274 )   Save Multi-drug resistance (MDR) of breast cancer is a key factor of breast cancer treatment failure. MicroRNA (miRNA) is a class of endogenous expressed, small, single-stranded RNA molecules, and regulate the expression of genes at post-transcriptional level by combining with target message RNA. MiRNA participate in the mechanisms of drug resistance of breast cancer, and are feasible therapeutic targets for the treatment of drug resistance in breast cancer. Finding and studying miRNA related with drug resistance of breast cancer as well as their mechanisms have become a current research hotspot. Related Articles | Metrics

Early diagnostic technology of breast cancer CHENG Liu-Liu, LI Jun 2013, 40 (6):  453-455.  Abstract ( 592 )   PDF (670KB) ( 1589 )   Save The early diagnosis of breast cancer is crucial for improving the prognosis of patients. Some new diagnostic techniques can improve the early diagnosis rate. Studies show that microRNA, proteins in salivary, urinary polyamines could be used as novel tumor markers, with high sensitivities and specificities. With the help of optical technology and computers, the traditional diagnostic imaging technique also make a great breakthrough. Currently, image-guided minimally invasive biopsy techniques such as core needle biopsy and vacuum assisted biopsy have the advantages of accuracy, economy and little trauma, and can provide more samples, which have been widely applied in clinical practice. Related Articles | Metrics

Molecular markers for prognosis of gastric cancer LI Cai-Yan, GU Kang-Sheng 2013, 40 (6):  456-459.  Abstract ( 597 )   PDF (677KB) ( 1496 )   Save A variety of molecular markers are related to the prognosis of gastric cancer, such as the the loss expression of AT rich interactive domain 1A (ARID1A), the overexpression of CD133 and survivin are releated to the incidence and poor prognosis of gastric cancer; leptin, CD44 and microRNA (miRNA) are releated to the invasion and metastasis of gastric cancer; the low expression of secreted protein acidic and rich in cysteine (SPARC) contributes to the angiogenesis of gastric cancer, but the relationship between SPARC and prognosis needs further study; the expression and gene polymorphism of excision repair cross-complementing 1 (ERCC1) may be useful for choice of medication in the treatment of gastric cancer. Related Articles | Metrics

Application of arsenic trioxide in gastric cancer treatment YU Yao, YANG Yu 2013, 40 (6):  460-462.  Abstract ( 783 )   PDF (673KB) ( 1249 )   Save Arsenic trioxide（As2O3）is the main component of traditional Chinese medicine arsenic, which was initially used in the treatment of blood system diseases. In recent years, studies have found that it also has a good effect on a variety of solid tumors, especially gastric cancer. It has been confirmed that As2O3 can inhibit proliferation and metastasis of gastric cancer cells, induce apoptosis and protective autophagy, inhibite lymphatic formation and angiogenesis, affect the expression of telomere-related proteins in gastric cancer cells. Related Articles | Metrics

Adjuvant chemotherapy of stage Ⅱ colon cancer CAO Jian, SUN Ping 2013, 40 (6):  463-465.  Abstract ( 579 )   PDF (673KB) ( 1480 )   Save For stage Ⅱ colon cancer patients after surgery，the benefit of adjuvant chemotherapy remains controversial. Several studies indicate that the patients with high-risk stage Ⅱ colon cancer can benefit from adjuvant chemotherapy after surgery. According to the clinical and pathological features, the stage Ⅱ colon cancer patients including T4 lesion, perforation, peritumoral lymphovascular invasion can benefit from the adjuvant chemotherapy of oxaliplatin. In the horizontal of molecular and genetic levels, the stage Ⅱ colon cancer patients can express high microsatellite instability (MSI-H) and cannot benefit from the chemotherapy of Fluorouracil. The guiding functions of 18q loss of heterozygosity (18q LOH), Cx43 and gene expression profiling in adjuvant chemotherapy are still unclear, and need further study. Related Articles | Metrics

Research of magnetic resonance spectroscopy on cervical cancer ZHAO Yan, FU Chun, FENG Xiao-Yan, WANG Xiang-Quan 2013, 40 (6):  465-468.  Abstract ( 481 )   PDF (678KB) ( 1455 )   Save Magnetic resonance spectroscopy (MRS) of cervical cancer can detect tumor related specific metabolic compounds such as choline, choline compounds, triglyceride, etc. MRS can be used in identification of benign or malignant lesions of cervix, diagnosis of cervical cancer and monitoring the efficacy  of radiotherapy and chemotherapy, etc. It will make for the clinical diagnodis and treatment of cervical cancer. Related Articles | Metrics

Application of photosensitizer drug delivery system in photodynamic therapy of tumors TU Qing-Feng, WANG Xiu-Li, SHI Lei, WANG Hong-Wei 2013, 40 (6):  469-471.  Abstract ( 587 )   PDF (673KB) ( 1708 )   Save In vitro or in vivo results of investigations into the development of photosensitizer drug delivery systems have demonstrated that the use of vehicles not only enhance the stability of photosensitizer, but also promote the accumulation of photosensitizer in tumor tissue, enhance the targetability of photodynamic therapy, the working depth, the yield of singlet oxygen and overcome many untoward effects. So the research of new photosensitizer drug delivery system has important application value in photodynamic therapy of tumor. Related Articles | Metrics

Clinical application of PCI-32765 for the treatment of B cell malignancies QU Fu-Lian, XIA Bing, ZHANG Yi-Zhuo 2013, 40 (6):  472-475.  Abstract ( 541 )   PDF (739KB) ( 1752 )   Save PCI-32765, an oral selective and irreversible inhibitor of Bruton tyrosine kinase (BTK), inhibits survival, activation, proliferation and migration of malignant B cells by blocking B cell receptor signaling pathway. PCI-32765 not only acts on malignant B cell, but also prevents resistance to chemical drugs. Therefore, PCI-32765 has broad prospects in the treatment of B cell malignancies. Related Articles | Metrics

Effects of microRNA-200b on proliferation and migration of colon cancer cells DU Ye-Ping, WU Chun-Mei, FANG Shu-Zhi, WU Jie, MIAO Jin-Hua- 2013, 40 (6):  476-479.  Abstract ( 538 )   PDF (1095KB) ( 1405 )   Save Objective  To study the effects of miR-200b on proliferation and migration of sw620 colon cancer cells, and its regulation effect on E-cadherin expression. Methods  The expressions of miR-200b in sw620 cells at 24 h and 72 h after pEGP-miR-200b transfection were detected by real-time PCR (RT-PCR). The change of the expression level of E-cadherin after miR-200b transfection was detected using the methods of RT-PCR and Western blot. The proliferation and migration abilities were measured by MTT and scratch test after miR-200b transfection. Results  The expressions of miR-200b in sw620 cells at 24 h and 72 h after pEGP-miR-200b transfection raised significantly compared to the control group (t=11.579, P＜0.01; t=11.579, P＜0.01). MiR-200b transfection inhibited the proliferation abilities of sw620 cells. It is the most significant of the inhibitory effect on the third day and the inhibition rate was 55.34%. MiR-200b transfection  markedly inhibited the migration abilities of sw620 cells. The two groups had significant difference in the migration distance of 24, 48, 72 h (t=11.579, P＜0.01; t=10.419, P＜0.01; t=6.955, P＜0.01). The mRNA and protein expressions of E-cadherin gene increased significantly by transfecting miR-200b gene in sw620 cells (t=10.432, P＜0.01; t=8.325, P＜0.01). Conclusion  Up-regulated expression of miR-200b could inhibite the proliferation and migration abilities of sw620 colon cancer cells. The involved molecular mechanism is probably related to the change of E-cadherin expression. Related Articles | Metrics