Abstract: Epithelial-mesenchymal transition (EMT) of cancer can enhance the abilities of invasion and metastasis of cancer cells, which is one of the reasons for treatment failure. Peroxisome proliferator-activated receptor gamma (PPARγ) is an important regulatory factor in EMT of cancer cells. Recent researches show that activation of PPARγ plays a role in the occurrence and development of EMT by regulating the E-cadherin, Smad complex and body microenvironment. Therefore, in-depth research for the relationship among PPARγ, EMT and cancer is expected to provide a new direction for tumor treatment.

Key words: PPAR gamma, Neoplasms, Smad protein, E-cadherin