Journal of International Oncology ›› 2013, Vol. 40 ›› Issue (6): 472-475.

Previous Articles     Next Articles

Clinical application of PCI-32765 for the treatment of B cell malignancies

QU  Fu-Lian, XIA  Bing, ZHANG  Yi-Zhuo   

  1. Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China

  • Online:2013-06-08 Published:2013-05-24
  • Contact: ZHANG Yi-zhuo E-mail:aprilzyz@yahoo.com

Abstract: PCI-32765, an oral selective and irreversible inhibitor of Bruton tyrosine kinase (BTK), inhibits survival, activation, proliferation and migration of malignant B cells by blocking B cell receptor signaling pathway. PCI-32765 not only acts on malignant B cell, but also prevents resistance to chemical drugs. Therefore, PCI-32765 has broad prospects in the treatment of B cell malignancies.

Key words: Lymphoma, Drug therapy, Signal transducing