Treatment of EB virus positive diffuse large B cell lymphoma

doi:10.3760/cma.j.cn371439-20200923-00075

Abstract

Abstract:

Epstein-Barr virus (EBV) positive diffuse large B cell lymphoma (DLBCL) is a rare type of B cell lymphoma associated with chronic EBV infection. The main subtype is activated B cell-like and it's invasive. The response to combined chemotherapy is worse than that of EBV negative patients, and the prognosis is poor. As the researches on pathogenesis and biological characteristics of EBV positive DLBCL deepen, new therapeutic strategies are emerging, such as antiviral therapy, monoclonal antibody, inhibitors of signaling pathway and immunotherapy including cellular immunotherapy and immune checkpoint inhibitor. These new therapeutic strategies can improve the efficacy and reduce the occurrence of adverse reactions.

Key words: Herpesvirus 4,human, Lymphomalarge B-cell,diffuse, Antibodies,monoclonal, Immunotherapy

Guo Yiwei, Liu Aichun. Treatment of EB virus positive diffuse large B cell lymphoma[J]. Journal of International Oncology, 2021, 48(7): 385-388.

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