Clinical application of histone deacetylase inhibitors in non-Hodgkin lymphoma

doi:10.3760/cma.j.cn371439-20220408-00096

Abstract

Abstract:

Great progress has been made in the treatment of lymphoma in recent decades, but the prognosis for patients with relapsed or refractory lymphoma is often disappointing. Studies have found that the pathogenesis of non-Hodgkin lymphoma is associated with changes in histone acetylation. Histone deacetylase inhibitors can increase the level of histone acetylation in lymphoma cells, and exert anti-lymphoma effects through mechanisms such as cell cycle inhibition, induction of apoptosis, and immunomodulation. However, histone deacetylase inhibitors alone have limited therapeutic effects, and the combination with other antineoplastic drugs for the treatment of relapsing and refractory non-Hodgkin lymphoma has shown good efficacy. Summarizing basic research and clinical trials of histone deacetylase inhibitor containing regimens provides ideas for the treatment of lymphoma.

Key words: Lymphoma, Epigenetic, Histone deacetylase inhibitor, Combination therapy

Yin Yunyan, Li Hui, Li Yuchen, Hui Hui, Xu Jingyan. Clinical application of histone deacetylase inhibitors in non-Hodgkin lymphoma[J]. Journal of International Oncology, 2022, 49(8): 499-504.

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