Abstract: Animal models using for research the cancer matestasis should be entirely similar to the clinical pathological process in patients. Currently, two kinds of animal models with genetic engineering and human tumor xenografts are available in laboratory, which provide a possible research tool to investigate the mechanism of tumor metastasis and explore the experimental treatment. In these models, the techniques including how to select the cell lines and using real-time imaging detection are very important factors.

Key words: Neoplasm metastasis, Animals, Cell line, Signal detection