Multidrug resistance mediated by ABCG2

Journal of International Oncology ›› 2013, Vol. 40 ›› Issue (6): 403-406.

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Multidrug resistance mediated by ABCG2

SHEN Fei, CHEN Bao-An

Zhongda Hospital, Medical School of Southeast University, Nanjing 210009, China

Online:2013-06-08 Published:2013-05-24
Contact: CHEN Bao-an E-mail:cba8888@hotmail.com

Abstract

Abstract: ABCG2 is a member of the ATP-binding cassette (ABC) transporter family. The overexpression of ABCG2 is identified as one of the important mechanisms that limiting cellular accumulation of various compounds. With regard to its broad substrate spectrum including various anticancer drugs and environmental carcinogens, the function of ABCG2 is associated with multidrug resistance (MDR) and tumor development. ABCG2 as a target site to reverse MDR has been widely concered.

Key words: Neoplasms, Drug resistance, multiple, ABCG2 protein, human

SHEN Fei, CHEN Bao-An. Multidrug resistance mediated by ABCG2[J]. Journal of International Oncology, 2013, 40(6): 403-406.

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Multidrug resistance mediated by ABCG2

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