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08 February 2013, Volume 40 Issue 2 Previous Issue    Next Issue

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Research progress of FLIP in cancer SHEN Jue, LI Yu-Feng, HE Zhen-Juan 2013, 40 (2):  83-85.  Abstract ( 656 )   PDF (762KB) ( 1584 )   Save FLIP is a protein containing death domain. Human beings have three subtypes of c-FLIPL, c-FLIPS and c-FLIPR, which can inhibit the apoptosis of a variety of tumor cells. C-FLIPL plays a dual role in the apoptotic signal. The expression level of FLIP not only decides the opening and closing of the apoptosis pathway but also achieve the conversion of cells in the apoptotic signaling and proliferative signaling pathway. The regulation of FLIP’s expression is a multi-layered, involving multiple signaling pathways. FLIP will probably become an attractive death receptor signaling target of therapy. Related Articles | Metrics

Research progress of thioredoxin-related protein 14 FU Zhi-Qin, XIE Xing, CHENG Xiao-Dong 2013, 40 (2):  86-89.  Abstract ( 643 )   PDF (692KB) ( 1222 )   Save Thioredoxin-related protein 14 (TRP14), a new member of Trx family, is a novel disulfide reductase with conservative CPDC motif. Its structure and function are comparable to Trx, which is the representative member of Trx family. However, there are many differences. When tumor necrosis factor-α (TNF-α) induced cells to produce the active oxygen, TRP14 can as a sensor of the intracellular redox state, change oxidation state of dynein lifht chain (its substrate), thereby regulate NF-κB signaling pathways induced by TNF-α, MAPK and apoptosis signaling pathways. Related Articles | Metrics

Advances of GOLPH2 in tumors LI Wen-Zhi, WANG Xiang, CHEN Gang 2013, 40 (2):  89-92.  Abstract ( 667 )   PDF (691KB) ( 1219 )   Save As a novel Golgi protein, GOLPH2 expression is associated with maintaining the structural integrity of the Golgi apparatus. As an oncoprotein, GOLPH2 expression is associated with malignant biological behavior of cancer cells. Important roles of GOLPH2 in the tumorigenesis and metastasis make it become a new target for tumor diagnosis and treatment. Related Articles | Metrics

Roles of apoptosis in the normal and tumor microenvironment DONG Shao-Ting, YANG Hong-Li, WANG Shuang 2013, 40 (2):  92-95.  Abstract ( 705 )   PDF (690KB) ( 1609 )   Save Apoptosis is the autonomous death of cells, which is controlled by the genes and to maintain the homeostasis of the body. Apoptosis is the important mechanism in the cell’s growth and development. Recent studies have found that apoptosis can affect the neighboring cells physiological process in microenvironment through directly contact or release a series of regulatory factor, which plays an important roles in the construction of tumor microenvironment. Therefore, understanding the roles of apoptosis in the normal and tumor microenvironment has great significance for further study the pathogenesis, prevention and treatment of tumor. Related Articles | Metrics

Applications of induced pluripotent stem cell in cancer therapy ZHANG Zhi-Qing, ZHAO Qing-Hua 2013, 40 (2):  96-99.  Abstract ( 641 )   PDF (689KB) ( 1972 )   Save Induced pluripotent stem cells (iPSCs) are derived from differentiated somatic cells through reprogramming in vitro. Similarly to embryonic stem cells (ESCs), iPSC have the ability of unlimited self-renewal and multiple differentiation potential. But they are without the constraints of immunology and ethics and acquire conveniently. Patient-specific iPSC provide an invaluable resource for disease modeling, drug discovery, regenerative therapy, immune therapy and cellular delivery vehicle in cancer therapy. Nowadays, the application of iPSC technology has made some progress in the treatment of tumors. Related Articles | Metrics

Tumor associated gene PFTK1 ZHU Jun, YUE Wen-Tao 2013, 40 (2):  100-102.  Abstract ( 744 )   PDF (680KB) ( 1511 )   Save PFTK1, an important member of cyclin dependent kinase Cdc2 family, is over expressed in many malignancies. PFTK1 involves in multiple processes, such as regulation of cell cycle, tumor invasion and metastasis, and the Wnt signal transduction pathway, which has a significant impact on prognosis of tumor. Related Articles | Metrics

Adoptive cellular immunotherapy for cancer SHANG Yi-Man, WANG Zi-Bing, MA Yi-Jie, ZHANG Yong, GAO Quan-Li 2013, 40 (2):  103-106.  Abstract ( 839 )   PDF (692KB) ( 2373 )   Save Adoptive cellular immunotherapy (ACI) achieves the elimination and control of tumor by mobilizing the body's immune function. It also has targeted efficacy and mild untoward effects. Cytokine-induced killer cells and tumor-infiltrating lymphocytes have been widely used in clinic and have obtained preliminary efficacy. With the development and clinical application of the specific gene transfer of T cell, it will further increase the efficacy of immunotherapy. At present, improving cell culture technology and cell function and using with other treatment are the key links to improve the efficacy of ACI. Related Articles | Metrics

Assessment of CIK cells in adoptive cellular therapy WANG Wen-Hao, LI Gui-Xin, LIU Jin 2013, 40 (2):  106-108.  Abstract ( 432 )   PDF (684KB) ( 1365 )   Save Cytokine-induced killer (CIK) cells therapy plays an important role in cancer adjuvant treatment. Researches show that the number of peripheral blood immunocytes will change if patients with cancer accept the treatment of CIK cells. The changes of T cell subsets, regulatory T cells are relatively obvious, which may be one of the standards that can evaluate the curative effect of CIK cells. Related Articles | Metrics

Transfer characteristics and therapeutic guide of level-Ⅰb lymph node in nasopharyngeal carcinoma HUANG Xiao-Guang, LIN Zhi-Xiong 2013, 40 (2):  109-111.  Abstract ( 806 )   Save Because of the lymphatic drainage of the neck area level-Ⅰb of nasopharyngeal carcinoma is particular, and “skip” metastasis in the cervical lymph node is rare, the involved region of level-I b lymph node metastasis rate is low in nasopharyngeal carcinoma. In the three-dimensional radiotherapy era of precision radiotherapy,  there is no consensus on whether level-Ⅰb need to be prophylactic irradiated in the clinic. Related Articles | Metrics

MicroRNA and the biological behaviour of human breast cancer JIE Yong-Song, LI Lian-Hong 2013, 40 (2):  111-114.  Abstract ( 769 )   PDF (690KB) ( 1450 )   Save MicroRNA (miRNA) controls the proliferation of breast cancer cells in many ways such as cell apotosis, cell cycle and methyltransferase. Also, it controls the metastasis of breast cancer cells in many ways such as microenvironment, epithelial-mesenchymal transition and vessel formation. Large amounts of recent studies indicate that miRNAs are specifically expressed in breast cancer tissue and play important roles in proliferation, metastasis and treatment of breast cancer. Related Articles | Metrics

Multiple molecular targets of resveratrol: anti-breast cancer mechanisms CHOU Feng-Qi, DING Xiao-Chao, MA Ping 2013, 40 (2):  114-117.  Abstract ( 1032 )   Save Resveratrol, which is produced by natural plants, has various biological activities, including anti-inflammatory, antioxidant and anticancer properties. Recently, it is found that resveratrol can inhibit the proliferation and promote the apoptosis of breast cancer through multiple molecular targets, which provides a theoretical basis for resveratrol used in the treatment of breast cancer. Related Articles | Metrics

Changes of estrogen receptor, progesterone receptor and C-erbB-2 expressions in different scheme pre- and post-neoadjuvant chemotherapies for breast cancer SHI Peng-Liang, ZHANG Nai-Qian, ZHANG Guo-Qiang 2013, 40 (2):  117-119.  Abstract ( 658 )   PDF (680KB) ( 1395 )   Save Neoadjuvant chemotherapy is widely used in the therapy of locally advanced breast cancer. In the recent studies, the expressions of ER, PR and C-erbB-2 in tumor may change in different scheme pre- and post-neoadjuvant chemotherapies for breast cancer. It is obviously changed in the neoadjuvant chemotherapy scheme of anthracyclines and paclitaxel/docetaxel, but hardly changed in anthracycline-based neoadjuvant chemotherapy scheme. Related Articles | Metrics

Lung adenocarcinoma progression schema YANG Zhen-Yu, FAN Zhi-Wen, ZHANG Lei 2013, 40 (2):  120-122.  Abstract ( 867 )   PDF (676KB) ( 1882 )   Save Lung adenocarcinoma is usually thought to follow a linear multistep progression schema, that is precancerous lesions progress to adenocarcinoma in situ, and progress to micro-invasive adenocarcinoma, eventually some lung adenocarcinoma happen diffusion. However, recent ?ndings reveal that this linear progression schema might not occur in all lung adenocarcinoma subtypes, and some subtypes show a kind of non-linear progression schema. The study of these two kinds of schemas can help for early detection of lung adenocarcinoma. Related Articles | Metrics

Application of pemetrexed for the treatment of non-small-cell lung cancer LI Jun, XU Xiang-Ying 2013, 40 (2):  123-126.  Abstract ( 801 )   PDF (692KB) ( 2744 )   Save Pemetrexed is a novel antifolate which is approved in the USA and Europe for the treatment of non-small-cell lung cancer (NSCLC). Researches reveal that pemetrexed enhances radiation-induced cell inactivation. A series of clinical trials of pemetrexed combined with radiotherapy for NSCLC also demonstrated that pemetrexed provides similar ef?cacy with lower toxicity and better tolerability than other third-generation chemotherapy drugs. Related Articles | Metrics

Gene polymorphisms in the nucleotide excision repair pathway and lung cancer susceptibility QIAN Ying-Ying, SHU Yong-Qian 2013, 40 (2):  126-130.  Abstract ( 740 )   PDF (701KB) ( 1453 )   Save Nucleotide excision repair (NER) pathway is one of the principal ways of the repair of DNA damage. The single nucleotide polymorphisms (SNP) of its key genes such as xeroderma pigmentosum group A (XPA) gene, excision repair cross complementing1 (ERCC1) gene and xeroderma pigmentosum group D (XPD) gene may be associated with differences in the DNA repair capacity and may influence an individual’s risk of lung cancer, because the variant genotype in those polymorphisms might destroy or alter repair function. Related Articles | Metrics

Surgical treatment of esophagogastric junction adenocarcinoma SHI Gui-Dong, FU Mao-Yong 2013, 40 (2):  130-133.  Abstract ( 890 )   PDF (691KB) ( 1552 )   Save There are a variety of surgical treatments of advanced esophagogastric junction cancer, type Ⅰ、Ⅱ mainly by transthoracic approach, part of the type Ⅱ by transabdominal approach, type Ⅲ mainly by left thoracoabdominal approach (LTA) or transabdominal. Intraoperative lymph node dissection is one of the most important factors which affect the postoperative survival rate. The cardia right lymph node (NO.1), the cardia left lymph node (NO.2), gastric lesser curvature (NO.3) and left gastric artery side (NO.7) should do regular cleaning. Related Articles | Metrics

Detection of the tumor markers in patients with gastric precancerous lesions LIU Zhong-Juan, CHENG Xin-Qi, GUO Zi-Jian, ZHAO Li-Na, QIU Ling 2013, 40 (2):  134-137.  Abstract ( 767 )   PDF (691KB) ( 1506 )   Save It is confirmed that chronic atrophic gastritis (CAG) which is caused by Helicobacter pylori is the main cause of gastric precancerous lesions. CAG is also the key determinant in gastric cancer risk assessment, which affects pepsinogen and gastrin-17 secretion. Most of the gastric cancer patients with poor prognosis, and non-invasive tools for gastric cancer screening and diagnosis are lacking. Therefore, the early detection of gastric cancer in order to reduce the disease mortality is necessary. Pepsinogen and gastrin-17 are biomarkers of gastric mucosa and gastric antra. The serological testing for the stomach-specific biomarkers offers the possibility to know preneoplastic gastric mucosal conditions. Related Articles | Metrics

Application of PET-CT in liver cancer SUN Li, LI Gong, ZHAO Ying, XU Cen-Cen 2013, 40 (2):  137-140.  Abstract ( 708 )   PDF (749KB) ( 1326 )   Save Positron emission tomography-computed tomography (PET-CT) plays an important role in the diagnosis and treatment of liver cancer.18F-FDG PET-CT imaging-positive rate is low due to a variety of factors affecting the hepatoma cells. But the joint imaging can significantly improve the diagnostic positive rate and provide the basic information for treatment selection and prognosis.PET-CT is better than conventional imaging techniques in the diagnosis and therapy monitoring for metastatic liver cancer. Related Articles | Metrics

Preoperative neoadjuvant therapy for locally advanced rectal cancer MEI Lan, XU Xiang-Ying 2013, 40 (2):  141-144.  Abstract ( 685 )   PDF (693KB) ( 1430 )   Save Preoperative radiotherapy combined with chemotherapy and (or) targeted therapy not only reduces the local recurrence of locally advanced rectal cancer and increases the rate of anal preservation and pathologic complete response, but also improves patient compliance. Preoperative neoadjuvant therapy will gradually become the standard treatment for locally advanced rectal cancer. Related Articles | Metrics

Diagnosis, treatment and prognosis of uterine cervical neoplasms complicated with pregnancy QIANG Su-Feng, HUANG Yong 2013, 40 (2):  145-148.  Abstract ( 638 )   PDF (688KB) ( 1155 )   Save The incidence of cervical neoplasms complicated with pregnancy is rising, with delaying of reproductive age. Because of the prevalence of cytology in pregnancy, cervical neoplasms complicated with pregnancy are mostly detected early. All patients with cytological abnormalities should undergo colposcopy, and when necessary, they should undergo cervical biopsy. Conization is reserved for patients with suspected invasion. In cases of invasive carcinoma detected up to the 12th week of pregnancy, immediate treatment is prioritized. Regarding diagnoses made during the second trimester, in early-stage invasive cancers, delay of therapy seems to be safe, fetal pulmonary maturity can be awaited. And the use of neoadjuvant chemotherapy to stabilize the disease until the time of delivery appears to be viable. Doctors should draw up personalized program for the patients with cervical neoplasms complicated with pregnancy according to stage of disease, gestational weeks and the patient’s desire for continued pregnancy. Cervical neoplasms complicated with pregnancy are mostly early-stage invasive cancers, so prognosis is good. Related Articles | Metrics

Inhibitory effect of antisense miR-30a-5p on glioma cell growth in vivo SUN Ji-Kui, JIA Zhi-Fan, PU Pei-Yu, WANG Guang-Xiu, ZHANG An-Ling, YANG Wei-Dong 2013, 40 (2):  149-152.  Abstract ( 697 )   PDF (1848KB) ( 1423 )   Save Objective To study the inhibitory effect of knocking down miR-30a-5p on the U87 human glioma xenograft growth and its possible mechanism. Methods Nude mice bearing subcutaneous U87 human glioblastoma were established and treated with miR-30a-5p antisense oligonucleotides (AS-miR-30a-5p) subcutaneous injection. Tumor size was measured every other day until the observation period ended. Researchers executed the animals after the treatment, stripped tumor tissues and extracted RNA and protein. Real-time PCR were conducted to detect the expression of miR-30a-5p. The histopathological characteristics and proliferation and apoptosis biological characters (including SEPT7, PCNA, cyclinD1, MMP-2, apoptosis related factor P53, bcl-2 and caspase3)were evaluated by HE and immunohistochemical staining, Western blot analysis respectively, and the cell apoptosis was detected by TUNEL method. Results In AS-miR-30a-5p treated group, the tumor growth was delayed and the final tumor volume was smaller than that in the control and scr-ODN treated group (F=7.167, P＜0.05), and the expression of miR-30a-5p was knocked down. The expression of PCNA、cyclinD1 were significantly down-regulated while P53、SEPT7 and caspase3 up-regulated. Apoptotic index was increased significantly. Conclusion As-miR-30a-5p suppresses the growth of U87 human gliomas xenografts significantly. Malignant phenotype of tumors are reversed to a considerable degree. Therefore, miR-30a-5p can be a candidate for targeted therapy of human glioma. Related Articles | Metrics

Survey of quality of life for patients with breast ductal carcinoma in situ and analysis of related factors JIANG Bei-Qi, FU Yun, WU Yi, CHENG Xiao-Lin, LI Zheng-Dong, ZHUANG Zhi-Gang 2013, 40 (2):  153-156.  Abstract ( 662 )   PDF (693KB) ( 1570 )   Save Objective To study the quality of life (QOL) of patientswith ductal carcinoma in situ (DCIS) and to analyze the relevant factors affecting their QOL. Methods A total of 84 patients with DCIS and 125 patients with invasive breast cancer were surveyed. Researchers used SF-36 to assess the QOL of participants at one year after operation. Some information of patients were analyzed the relationship to SF-36 score, such as age, the type of surgery, endocrine therapy, education, marital status, working status and health insurance. Results Compared to normal women, patients with DCIS had lower QOL in physical function (P=0.029), bodily pain (P=0.039), general health (P=0.033) and mental health (P=0.003). Patients with invasive breast cancer also had poorer QOL in physical function (P=0.002), bodily pain (P=0.002), vitality (P=0.002), general health (P=0.002) and mental health (P=0.001). QOL of DCIS patients were similar to that of invasive breast cancer patients, except that score of physical function (P=0.032) and vitality (P=0.040) were better in DCIS patients. Endocrine therapy significantly affected the score of QOL of DCIS patients. DCIS patients with endocrine therapy had poorer score in physical function (P=0.034), bodily pain (P=0.046), general health (P=0.031), vitality (P=0.042) and mental health (P=0.002). Conclusion Patients with DCIS have poor QOL at one year after operation. Endocrine therapy significantly reduces their QOL. Related Articles | Metrics