Abstract: It is confirmed that chronic atrophic gastritis (CAG) which is caused by Helicobacter pylori is the main cause of gastric precancerous lesions. CAG is also the key determinant in gastric cancer risk assessment, which affects pepsinogen and gastrin-17 secretion. Most of the gastric cancer patients with poor prognosis, and non-invasive tools for gastric cancer screening and diagnosis are lacking. Therefore, the early detection of gastric cancer in order to reduce the disease mortality is necessary. Pepsinogen and gastrin-17 are biomarkers of gastric mucosa and gastric antra. The serological testing for the stomach-specific biomarkers offers the possibility to know preneoplastic gastric mucosal conditions.

Key words: Stomach neoplasms, Gastritis, atrophic, Pepsinogen A, Pepsinogen B, Gastrins, Helicobacter pylori