Abstract: Apoptosis is the autonomous death of cells, which is controlled by the genes and to maintain the homeostasis of the body. Apoptosis is the important mechanism in the cell’s growth and development. Recent studies have found that apoptosis can affect the neighboring cells physiological process in microenvironment through directly contact or release a series of regulatory factor, which plays an important roles in the construction of tumor microenvironment. Therefore, understanding the roles of apoptosis in the normal and tumor microenvironment has great significance for further study the pathogenesis, prevention and treatment of tumor.

Key words: Apoptosis, Neoplasms, Macrophages, Tumor microenviroment