Abstract: Thioredoxin-related protein 14 (TRP14), a new member of Trx family, is a novel disulfide reductase with conservative CPDC motif. Its structure and function are comparable to Trx, which is the representative member of Trx family. However, there are many differences. When tumor necrosis factor-α (TNF-α) induced cells to produce the active oxygen, TRP14 can as a sensor of the intracellular redox state, change oxidation state of dynein lifht chain (its substrate), thereby regulate NF-κB signaling pathways induced by TNF-α, MAPK and apoptosis signaling pathways.

Key words: Thioredoxins, Tumor necrosis factor-alpha, Thioredoxin-related protein 14