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08 March 2015, Volume 42 Issue 3 Previous Issue    Next Issue

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Effect of miR27a on cell proliferation and apoptosis in human melanoma cell line WM239 MA Ya-Nan, WANG Bao-Hong, SU Qing-Hong, XU Xiao-Qun, WANG Jun-Fu 2015, 42 (3):  161-164.  doi: 10.3760/cma.j.issn.1673422X.2015.03.001 Abstract ( 427 )   PDF (2031KB) ( 1546 )   Save ObjectiveTo investigate the effect of miR27a mimic and inhibitor on proliferation and apoptosis in melanoma cell line WM239. MethodsThe miR27a mimic, inhibitor and its negative control were transfected into WM239 cells. The transfection efficiency was evaluated by fluorescence microscope. The expression of miR27a was detected by realtime fluorescent quantitative PCR. The proliferation of cells was detected by MTT. The cell apoptosis and cell cycle were analyzed by flow cytometry. ResultsThe transfection efficiency in WM239 cells was 80% to 90%. The expression of miR27a was markedly upregulated in miR27a mimic group（2△△CT value is 26.98±0.01), with statistically significant difference(t＝-1 123.67, P=0.00）; and the miR27a inhibitor group showed lower expression of miR27a（2△△CT value is 0.96±0.02),  there was no statistically significant difference compared with normal control group(t＝0.04, P＝0.06）. The proliferation of cells was obviously inhibited in miR27a mimic group, and there was statistically significant difference compared with normal control group ［absorbance of 72 h（0.45±0.02）∶（0.72±0.01），F＝129.56, P＜0.05］. The percentage of WM239 cells in G0G1 phase was increased［（74.83±1.46）∶（63.73±1.25），F＝30.33, P＜0.05］, and the percentage of WM239 cells in S phase and G2M phase were decreased ［（21.33±1.75）∶（27.50±1.25），F＝14.98，P＜0.05；（3.90±1.31）∶（8.80±2.10），F＝3.66，P＜0.05］. The apoptosis rate of cells was significantly increased in miR27a mimic group compared with normal group ［（29.67±0.91）%∶（1.44±0.85）%，F＝530.90，P＜0.01］, but the inhibitor group had no obvious effect on cell cycle and cell apoptosis. ConclusionMiR27a can suppress melanoma cell proliferation and act as a tumor suppressor gene, which is relevant to induce cell apoptosis and block cell cycle in G0G1 phase. Related Articles | Metrics

Correlational study of peritumoral brain edema, histological grades and the expression of Ki67 in gliomas Hong-Yu, ZHENG Yong, WU Yong-Gang, ZHANG Cheng, WANG Ji-Chao 2015, 42 (3):  165-168.  doi: 10.3760/cma.j.issn.1673422X.2015.03.002 Abstract ( 452 )   PDF (728KB) ( 1554 )   Save ObjectiveTo explore the correlation of peritumoral brain edema (PTBE) size, histological grades and the expression rate of Ki67 in gliomas. MethodsThe data and specimens about 74 cases of gliomas in People's Hospital of Xinjiang Uygur Autonomous Region during 20102013 were collected. All cases were confirmed by surgery and pathology. According to preoperative MRI, PTBE was graded. Immunohistochemical discriminate the expression of Ki67. HE coloration distinguish the histological grades.ResultsIn this study, 90.54% (67/74) patients occured PTBE, the incidence of PTBE inⅠ, Ⅱ, Ⅲ, Ⅳ level of groups were 100%(3/3), 78.95% (15/19), 83.33% (15/18), 100% (34/34). Ki67 expression was positive in 75.68% (56/74) patients, and the rates were 0, 36.84% (7/19), 94.44% (17/18), 94.12% (32/34) in Ⅰ, Ⅱ, Ⅲ, Ⅳ level of groups. The expression rate of Ki67 was 57.14% (4/7), 60.00% (6/10), and 80.70% (46/57) in  normal group, Ⅰlevel groups of PTBE, Ⅱlevel groups of PTBE. The result of KruskalWallis H showed that  the PTBE from different grades was statistically significant (H=11.304, P=0.010). The expression rate of Ki67 in different grade gliomas was statistically significant (H=38.530, P＜0.05), The difference of expression Ki67 in gliomas of different PTBE was statistically significant (H=6.478, P=0.039). The result of Spearman rank correlation analysis showed that the PTBE level increased with the histological grade up in gliomas (r=0.385, P=0.001). The expression rate of Ki67 increased with the histological grade up in gliomas (r=0.692, P＜0.05), and the expression rate of Ki67 increased with the degree of  PTBE up in glomas (r=0.256, P=0.028).ConclusionAccorrding to the PTBE size, the histological grades and proliferation ability of glioma can be judged preoperation. Ki67 can be used as the indicator of proliferation activity of tumor, and also be used as the important basis of histological grades. Related Articles | Metrics

Expression and clinical significance of MGMT, Ki 67 and P53 in human gliomas LAI Jun, LUO Lin 2015, 42 (3):  169-171.  doi: 10.3760/cma.j.issn.1673422X.2015.03.003 Abstract ( 402 )   PDF (719KB) ( 1470 )   Save ObjectiveTo detect the expression of  DNA repair enzyme O6methylguanine DNA methyltransferase (MGMT), cell proliferationrelated nuclear protein (Ki67) and P53 protein in gliomas, and investigate the relationship and clinical significance among them and gloma grade. Methods61 cases of brain glioma specimes and 16 cases of internal decompression of brain trauma were used to detect the expression of MGMT, Ki67 and P53 by using immunohistochemical SP method. ResultsMGMT protein expression (19.67%∶0， χ2=3.729，P=0.062), Ki67 protein expression (39.34%∶0， χ2=5.722，P=0.016) and P53 protein expression (27.87%∶0， χ2=9.146，P=0.002) showed significant differences in gliomas compared to normal brain tissues, the expression of Ki67 was significantly higher in highgrade gliomas(ⅢⅣ) than that in lowgrade gliomas (ⅠⅡ) (14∶10， χ2=11.718，P=0.001). No significant difference was found between the MGMT and P53.ConclusionMGMT protein can be used as a biomarker in gliomas detection; Ki67 has a positive correlation with tumor grade, and can be used as a reference indicator of pathological grade; P53 protein expression may be used as a potential target for the treatment of gliomas. Related Articles | Metrics

Multivariate analysis of factors influencing hepatocellular carcinoma prognosis after hepatectomy SI Di-Ke-Jiang-Yi-Bu-La-Yin, LIU Hong-Liang, WU Xiao-Long, ZHAO Ya-Jie, JI Ran, CHEN Yi-Fa- 2015, 42 (3):  172-176.  doi: 10.3760/cma.j.issn.1673422X.2015.03.004 Abstract ( 323 )   PDF (1530KB) ( 1314 )   Save ObjectiveTo retrospectively study the relationship between several risk factors such as cirrhosis, ChildPugh classification, tumor size, portal vein tumor thrombus, intraoperative transfusion, hepatic portal occlusion time and the prognosis of hepatic cellular cancer (HCC) patients after hepatic resection. MethodsThe clinical data of 123 patients who received hepatic resection for HCC at Tongji Hospital between 2007 and 2009 were retrospectively analyzed. LogRank test and Cox proportional hazard model were used in the univariate and multivariate analyses of risk factors. Results1, 2, 3, 5 year recurrence and survival rates were 54.17%, 66.67%, 81.40%, 87.50% and 93.50%, 73.17%, 58.54%, 27.64%, respectively. The mean recurrence time and survival time were 19.5 months and 42.9 months. In univariate analysis, presence of cirrhosis (χ2=11.159, P=0.005), ChildPugh classification (χ2=7.715, P=0.028), tumor size (≥5cm) (χ2=11.483，P=0.004), presence of portal vein invasion (χ2=22.271, P=0.001) were risk factors affecting HCC recurrence. In multivariate analysis, presence of cirrhosis (χ2=8.993, P=0.003), tumor size (≥5cm) (χ2=4.022, P=0.039), presence of portal vein invasion (χ2=5.023, P=0.027) were independent risk factors affecting HCC recurrence. In univariate analysis, presence of cirrhosis (χ2=7.339，P=0.025), AFP>400 ng/ml (χ2=5.431，P=0.042), ChildPugh classification (χ2=13.389, P=0.002), tumor size(≥5cm) (χ2=11.342，P=0.003), presence of portal vein invasion (χ2=52.167, P＜0.001), hepatic portal occlusion (χ2=5.801, P=0.037), intraoperative blood transfusion (χ2=14.959, P=0.001) were risk factors affecting a shorter overall survival. In multivariate analysis, presence of cirrhosis (χ2=9.133, P=0.003), ChildPugh classification (χ2=4.799, P=0.028), tumor size (≥5 cm) (χ2=9.101, P=0.004), presence of portal vein invasion (χ2=11.126, P=0.001), hepatic portal occlusion (χ2=3.985, P=0.046) were independent prognostic factors affecting shorter overall survival. ConclusionCirrhosis, ChildPugh classification, tumor size (≥5 cm), presence of portal vein invasion, and hepatic portal occlusion were independent prognostic factors for HCC patients after hepatic resection. Related Articles | Metrics

The value of combined detection with MMP9 and uPA in prognosis of pancreatic carcinoma Li-Shi-Jie, HU Jun-Hong, XIE Yong-Zheng, REN Xue-Qun, JIA Fu-Xin, LIU Jiang-Wei 2015, 42 (3):  177-181.  doi: 10.3760/cma.j.issn.1673422X.2015.03.005 Abstract ( 468 )   PDF (1392KB) ( 1419 )   Save ObjectiveTo explore the value of combined detection with MMP9 and uPA in the prognosis of pancreatic carcinoma. MethodsBy immunohistochemistry PV methods，the expression of MMP9 and uPA was respectively studied in 63 surgical specimens of primary pancreatic carcinoma and the survival time of patients with pancreatic carcinoma was analysed. ResultsThe expressions of MMP9 and uPA  were positively related （r=0.573，P=0.000）. The expression of MMP9 and uPA significantly correlated with differentiation（r=-0.271，P=0.032；r=-0.333，P=0.008）, TNM stages（r=-0.449，P=0.000；r=-0.430，P=0.000）and lymph node metastasis（r=0.329，P=0.009；r=0.400，P=0.001）, separately. The expression of MMP9 had also a significant correlation with tumer size（r=-0.297，P=0.018）and distant metastasis（r=0.320，P=0.011）．Univariate analysis identified that tumor size（χ2=8.766，P=0.012）,differentiation（χ2=29.050，P=0.000）,clinical stage（χ2=24.940，P=0.000）,distant metastasis（χ2=12.846，P=0.000）,lymph node metastasis（χ2=15.457，P=0.000）,MMP9（χ2=32.700,P=0.000）and uPA（χ2=41.495,P=0.000）were significantly associated with prognosis. KaplanMeier survival analysis showed that 1year survival rate of patients with MMP9 (-)，uPA (-)were significantly longer than that of the patients with MMP9 (+)，uPA (+),respectively(χ2=32.700，P=0.000；χ2=41.495，P=0.000)；1year survival rate of  patients with MMP9 (-)/uPA(-)was significantly longer than the others(Logrank test，χ2= 54.892, P=0.000).COX regression revealed that differentiation (RR=2.315，P=0.004),clinical stage（RR=1.694,P=0.002）,MMP9（RR=0.165,P=0.000） and uPA（RR=0.244,P=0.007）was independent prognostic factors in pancreatic carcinoma. ConclusionThey may have a synergistic function in the the process of growth and invasion in pancreatic cancer between MMP9 and uPA, and the posssible mechanism is that uPA activate degradation of MMP9, which is not favorable to prognosis.Combined analysis of MMP9 and uPA may lead to a more reliable prognostic estimation,as the beneficial supplement of the differentiation, and clinical stage to judge the prognosis of pancreatic cancer. References | Related Articles | Metrics

A Metaanalysis of transcatheter arterial chemoembolization comparing stereotactic body radiation therapy in patients for primary hepatic carcinoma Chen-Ya-Ping, JIANG Xiao-Xiao, JIANG Guan, FENG Shou-Xin 2015, 42 (3):  182-187.  doi: 10.3760/cma.j.issn.1673422X.2015.03.006 Abstract ( 336 )   PDF (2520KB) ( 1464 )   Save ObjectiveTo compare the clinical efficacy and the adverse reaction of transcatheter arterial chemoembolization (TACE) alone and combined with stereotactic body radiation therapy (SBRT) in patients with primary hepatic carcinoma by a Metaanalysis. MethodsPubMed, Cochrane Library, EMBase, Ovid, MEDLIN, CNKI, CBMdisc, VIP and Wanfang were searched to identify the controlled clinical trials of TACE and SBRT for primary hepatic carcinoma. The obtained data were analyzed using Review Manager version 5.2 provided by Cochrane Collaboration. To analysis the shortterm effect of TACE alone or combined with SBRT，the rate of local tumor control and the difference of one, two, three and fiveyear survival rate. ResultsA total of 1 143 patients from 10 controlled clinical trials were involved according to the inclusion criteria. The Metaanalysis showed that TACE and SBRT group significantly increased the shortterm effective rate, the rate of local tumor control, l,2,3and 5year overall survival rates(RR=1.43,95%CI:1.321.56,P<0.000 01;RR=2.09,95%CI:1.632.69,P<0.000 01; RR=1.31,95%CI:1.211.42, P<0.000 01; RR=1.46, 95%CI:1.231.72, P<0.000 01; RR=1.76,95%CI:1.142.71,P=0.01;RR=2.29,95%CI:1.224.32,P=0.01). There was no statistically significant difference between the two groups on adverse events such as leucopenia(RR=0.97,P=0.61), thrombocytopenia(RR=0.99,P=0.85), hemoglobin decrease(RR=0.95,P=0.63), nausea and vomiting(RR=1.00,P=0.98), liver function damage(RR=0.98,P=0.87).ConclusionCompared with TACE, TACE combined with SBRT can increase the shortterm effective rate, the rate of local tumor control, the 1, 2, 3and 5year overall survival time of the patients, and does not increase the incidence of adverse reaction. However highquality trials with large sample sizes are still needed to verify the longterm efficacy and safety. Related Articles | Metrics

Ubiquitin and its role in the tumor GAO Xiao-Jia, YANG Hui, WU Lin, ZHOU Fu-Xiang, ZHOU Yun-Feng 2015, 42 (3):  188-191.  doi: 10.3760/cma.j.issn.1673422X.2015.03.007 Abstract ( 792 )   PDF (726KB) ( 2124 )   Save Ubiquitinproteasome pathway is one of the primary pathway in intracellular protein degradation, therefore the ubiquitin conjugating enzyme D3 (UbE2D3) which involved in the ubiquitin mineralization process can affect the biological effects accordingly to affect some protein and nucleic acid content and activity. The function that participate in modification and degradation of some cancer factors is vital in tumor cells, and followed by tumor biological behavior changing. Researches show that UbE2D3 correlates with human telomerase reverse transcriptase (hTERT), radiation sensitivity, aggressive, etc in breast cancer. Related Articles | Metrics

Clinical research on malignant tumor of the skull base CAI Hong-Qing, WAN Jing-Hai 2015, 42 (3):  192-195.  doi: 10.3760/cma.j.issn.1673422X.2015.03.008 Abstract ( 295 )   PDF (721KB) ( 1407 )   Save Malignant tumors of the skull base are rare, present with a variation of histologic stypes, and don′t have specific symptoms. Their treatment paradigms differ with histology, location and stage. Many times it is essential to need multidisciplinary cooperation for dealing them. A better understangding of malignant tumors of the skull base will be beneficial for standardized treatment. Related Articles | Metrics

Epigenetic modifications and nonsmall cell lung cancer ZHAO Chen-Hui, SHU Yong-Qian 2015, 42 (3):  196-199.  doi: 10.3760/cma.j.issn.1673422X.2015.03.009 Abstract ( 483 )   PDF (725KB) ( 1407 )   Save In nonsmall cell lung cancer (NSCLC), a major characteristic is the abnormal methylation of some certain genes. The hypomethylation of protooncogene has the potential to promote carcinogenesis and the formation of neoplasm may also be induced by the hypermethylation of tumor suppressor genes. Meanwhile, the balance between histone acetylation and deacetylation is closely connected to the tumorigenesis. While the histone acetyltransferases can directly acetylate genes related to proliferation, causing cell growth and transformation, histone deacetylase will also alter the level of acetylation of certain proteins, and eventually affect NSCLC. Hence, these abnormal epigenetic modifications play a fundamental role in the formation and development of NSCLC. Related Articles | Metrics

Mechanisms of COX2 inhibitors combinated with cisplatin for lung cancer Wei-Hui, ZHANG Qing 2015, 42 (3):  200-202.  doi: 10.3760/cma.j.issn.1673422X.2015.03.010 Abstract ( 303 )   PDF (716KB) ( 1326 )   Save Selective COX2 inhibitors can promote the apoptosis of tumor cells and block the growth of new blood vessels through the inhibition of ring oxidase, vascular endothelial growth factor, microvessel and so on. Research shows that COX2 is overexpressed in vascular and endothelial cells of lung cancer, select COX2 inhibitors to adjuvant chemotherapy, not only can directly inhibit the tumor proliferation, but also can reduce the adverse reaction of chemotherapy drugs, and enhance the curative effect. To investigate the effects of selective COX2 inhibitors and cisplatin in lung cancer angiogenesis and its mechanism, will be a hope for the clinical treatment of tumor. Related Articles | Metrics

COX2 and its inhibitors in lung cancer drug resistance HAN Hui, ZHANG Qing 2015, 42 (3):  203-205.  doi: 10.3760/cma.j.issn.1673422X.2015.03.011 Abstract ( 338 )   PDF (720KB) ( 1324 )   Save COX2 is the inducible form of cyclooxygenase, which is overexpressed in nonsmall cell lung cancer, especially in the adenocarcinoma, and is involved in the production of lung cancer drug resistance, reducing the sensitivities of tumor cells to chemotherapy drugs. COX2 inhibitors have the effects of antitumor and prevention of tumor formation. Therefore, in order to reverse the drug resistance of tumor cells, improve the survival rate and the prognosis of patients with tumor, the application of COX2 inhibitors as adjuvant chemotherapy and combined with chemotherapy drugs has become a new direction in the treatment of lung cancer. Related Articles | Metrics

Research progression on resistance mechanisms of epidermal growth factor receptor tyrosine kinase inhibitors in nonsmall cell lung cancer LIU Yun, FENG Ji-Feng, YAN Zhao-Yue 2015, 42 (3):  206-209.  doi: 10.3760/cma.j.issn.1673422X.2015.03.012 Abstract ( 313 )   PDF (785KB) ( 1386 )   Save EGFRTKI plays an important role in the treatment of nonsmallcell lung cancer. However, some researchers find that there are still some patients with primary or acquired resistance to EGFRTKI. The present known mechanisms of acquired drug resistance finally lead to the reactivation EGFR downstream signaling pathways. Liver X receptor agonist has inhibition function to several critical steps of EGFR downstream signaling pathways PI3KAktNFκB, which makes it possible to overcome the drug resistance. Related Articles | Metrics

Progress of immunotherapy trials in the treatment of lung cancer LIU Hao, GAO Hong-Jun 2015, 42 (3):  214-217.  doi: 10.3760/cma.j.issn.1673422X.2015.03.013 Abstract ( 524 )   PDF (727KB) ( 1251 )   Save Surgery in combination with chemotherapy and radiotherapy is the standard of lung cancer treatment, but postoperative recurrence is very common which usually leads to higher mortality and lower life quality. Immunotherapy on postoperative patients fully mobilizes the body′s defense mechanisms, activates the immune cells, and kills residual cancer cells. Current research on lung cancer immunotherapy mainly includes four categories: adoptive immunotherapy, dendritic cell vaccine, nonspecific antigen immune therapy and antigenspecific vaccine.These studies show lung cancer immunotherapy intervention can effectively reduce postoperative residual cancer cells, reduce postoperative recurrence rate, prolong survival, significantly improve the prognosis, and is worth spreading in clinical practice. Related Articles | Metrics

Status treatment of the Ⅳ stage esophageal cancer ZHENG Tao, LI Tao, WU Jing-Bo 2015, 42 (3):  214-217.  doi: 10.3760/cma.j.issn.1673422X.2015.03.014 Abstract ( 147 )   PDF (726KB) ( 1366 )   Save The Ⅳ stage esophageal cancer refers to exist regional lymph nodes and distant organs in patients with metastases. Palliative chemotherapy and radiotherapy is the primary treatment. With the deepening of the clinical study, radiotherapy and chemotherapy are no longer single treatment, chemotherapy combined molecular targeted drugs, chemoradiotherapy and some new treatment methods have been gradually recognized, and especially molecular targeted drugs began to establish its position in the treatment of tumor. Application of various methods individual or combined treatment can effectively prolong survival and improve the quality of life. Related Articles | Metrics

Mechanisms of helicobacter pylori on the occurrence of gastric cancer WU Lai, HOU Yun-Xiu 2015, 42 (3):  218-220.  doi: 10.3760/cma.j.issn.1673422X.2015.03.015 Abstract ( 399 )   PDF (716KB) ( 1430 )   Save Helicobacter pylori is one of causes of gastric cancer. It can cause mucosal inflammation cytokines aggregation, gastric mucosal damage; and through a variety of ways to activate epithelial cells multiple oncogenic pathways, including phosphatidylinositol 3 kinase (PI3K) pathway, Wntβcatenin and epoxidized synthase 2 (COX2)prostaglandin E2 antibody (PGE2) pathway, so as to change the gastric stem cell microenvironment and disrupt the gastric stem cell differentiation and proliferation, making the normal gastric stem cells evolved into cancer stem cells. Related Articles | Metrics

Malnutrition related factors in patients with gastric cancer LI Rong, YANG Xiao-Yun, SHEN Li-Da 2015, 42 (3):  221-223.  doi: 10.3760/cma.j.issn.1673422X.2015.03.016 Abstract ( 276 )   PDF (720KB) ( 1255 )   Save Malnutrition is one of the most important factors for the prognosis of patients with gastric cancer, but the mechanism of malnutrition is unclear at present. These patients are at risk of nutritional depletion from anorexia, dysphagia, and may be associated with the presence of two or more of the following cytokines with metabolic activity such as TNFα, IL1, IL6, interferon, leptin, nuclear factorκB and so on, which are secreted by  the hosttumor interaction. The cytokines constitute a sophisticated regulatory network. Therefore, the study of the relationship between malnutrition and related factors in patients with gastric cancer may improve the nutritional status and prognosis of these patients. Related Articles | Metrics

Akt inhibitors in the treatment of colorectal cancer DIAO Cun-Qi, BI Jing-Wang, WANG Bao-Cheng 2015, 42 (3):  224-227.  doi: 10.3760/cma.j.issn.1673422X.2015.03.017 Abstract ( 312 )   PDF (726KB) ( 1421 )   Save Protein kinase B(Akt) is an intermediate signal molecule in PI3KAktmTOR signaling pathway which plays an important role in development and incidence of colorectal cancer when activated by phosphorylation. As target of drugs, Akt has become a focus in the treatment of colorectal cancer. Clinical trials research proves that many kinds of Akt inhibitors have good antitumor activity. In recent years, the Akt inhibitors are more and more be taken seriously in colorectal cancer treatment. Related Articles | Metrics

The current treatment progress of colorectal cancer with liver metastases GUO Xiao-Jing, CAO Ni-Da, TAO Li, GU Ying, ZHU Ying-Jie, ZHENG Jian 2015, 42 (3):  228-231.  doi: 10.3760/cma.j.issn.1673422X.2015.03.018 Abstract ( 364 )   PDF (725KB) ( 1840 )   Save The multidisciplinary synthetic therapy for the colorectal liver metastases has been a hot spot in clinical research, which includes operative therapy, tumor local therapy, conversion therapy, chemotherapy, molecular targeted therapy and so on. It is need to choose multiple therapies for the patients and make the whole treatment strategy in accordance with the condition of patients to maximize the survival benefit in clinical practice. So, it is important to comprehend the newest research process of the clinical therapy to make a good choice for the colorectal liver metastases patients. Related Articles | Metrics

Adaptive external beam radiotherapy of cervical carcinoma ZHANG Ning, WANG Fan 2015, 42 (3):  232-234.  doi: 10.3760/cma.j.issn.1673422X.2015.03.019 Abstract ( 422 )   PDF (717KB) ( 1253 )   Save Radiotherapy has become one of the most important treatments for cervical carcinoma. In recent years, because of the organ motion, anatomical changes and setup errors et cetera, the accurate external beam radiotherapy (EBRT) may regard to the difference between the actual dose delivery and the pretreatment plan, which not only causes target less, but also brings additional doses to the organs at risk (OAR). By using of image guidance and individual modelling, adaptive radiotherapy (ART) can analyze the parameters of target position, volume and dose and adjust optimized plans for the followup treatment based on aforesaid feedbacks and enable the enhancement of the local control rate while reducing the incidence of the side reaction. Related Articles | Metrics

The research progress of CD44 and antileukemia effect WANG Yuan, GAO Xiao-Han, HAO Hong-Ling 2015, 42 (3):  235-237.  doi: 10.3760/cma.j.issn.1673422X.2015.03.020 Abstract ( 446 )   PDF (717KB) ( 1471 )   Save Leukemia is a kind of cloning disease from malignant hematopoietic stem cells. Its pathogenesis may have relationship with proliferation out of control, dysdiffreentiation and inhibition of apoptosis about leukemia cells. The study confirms that  CD44 is expressed in leukemia cells, promoting the occurrence and development of leukemia through participation in cell adhension, proliferation, migration and invasion behavior. In vitro experiment shows that CD44 targeted therapies can effectively kill leukemia cells, and reduce the toxicity to normal tissue cells. Therefore, aiming at the design of the anticancer drugs targeted for CD44 is expected to be used in clinical treatment of leukemia. Related Articles | Metrics

Research progress of cancer related anemia WEI Hui-Kai, AN Ning, ZHANG Xian-Qing, HU Xing-Bin 2015, 42 (3):  238-240.  doi: 10.3760/cma.j.issn.1673422X.2015.03.021 Abstract ( 350 )   PDF (721KB) ( 1587 )   Save Cancer related anemia (CRA) is one of the ancer complications. The incidence rate of CRA is more than 70% in patients after receiving chemotherapy, radiation therapy, or both. CRA has severe clinical symptoms which significantly attenuate effectiveness of cancer treatment and the quality of patients′ life. The current treatments for CRA, such as transfusion, recombinant EPO therapy, iron supplement and so on, could correct CRA in some sense. However, the present accepted therapeutic approaches could not be satisfied since there are complexity and diversity factors accounting for CRA. More effective and safety treatments of CRA are required in the near future. Related Articles | Metrics