Abstract: Protein kinase B(Akt) is an intermediate signal molecule in PI3KAktmTOR signaling pathway which plays an important role in development and incidence of colorectal cancer when activated by phosphorylation. As target of drugs, Akt has become a focus in the treatment of colorectal cancer. Clinical trials research proves that many kinds of Akt inhibitors have good antitumor activity. In recent years, the Akt inhibitors are more and more be taken seriously in colorectal cancer treatment.

Key words: Colorectal neoplasms, Targeted therapy, PI3KAktmTOR signal pathway