Abstract: Malnutrition is one of the most important factors for the prognosis of patients with gastric cancer, but the mechanism of malnutrition is unclear at present. These patients are at risk of nutritional depletion from anorexia, dysphagia, and may be associated with the presence of two or more of the following cytokines with metabolic activity such as TNFα, IL1, IL6, interferon, leptin, nuclear factorκB and so on, which are secreted by  the hosttumor interaction. The cytokines constitute a sophisticated regulatory network. Therefore, the study of the relationship between malnutrition and related factors in patients with gastric cancer may improve the nutritional status and prognosis of these patients.

Key words: Stomach neoplasms, Cytokines, Nutritional status