Abstract: Helicobacter pylori is one of causes of gastric cancer. It can cause mucosal inflammation cytokines aggregation, gastric mucosal damage; and through a variety of ways to activate epithelial cells multiple oncogenic pathways, including phosphatidylinositol 3 kinase (PI3K) pathway, Wntβcatenin and epoxidized synthase 2 (COX2)prostaglandin E2 antibody (PGE2) pathway, so as to change the gastric stem cell microenvironment and disrupt the gastric stem cell differentiation and proliferation, making the normal gastric stem cells evolved into cancer stem cells.

Key words: Stem cells, Helicobacter pylori, Tumor microenvironment