Abstract: The multidisciplinary synthetic therapy for the colorectal liver metastases has been a hot spot in clinical research, which includes operative therapy, tumor local therapy, conversion therapy, chemotherapy, molecular targeted therapy and so on. It is need to choose multiple therapies for the patients and make the whole treatment strategy in accordance with the condition of patients to maximize the survival benefit in clinical practice. So, it is important to comprehend the newest research process of the clinical therapy to make a good choice for the colorectal liver metastases patients.

Key words: Colorectal neoplasms, Neoplasm metastasis, Surgical procedures, operative, Molecular targeted therapy