Abstract: COX2 is the inducible form of cyclooxygenase, which is overexpressed in nonsmall cell lung cancer, especially in the adenocarcinoma, and is involved in the production of lung cancer drug resistance, reducing the sensitivities of tumor cells to chemotherapy drugs. COX2 inhibitors have the effects of antitumor and prevention of tumor formation. Therefore, in order to reverse the drug resistance of tumor cells, improve the survival rate and the prognosis of patients with tumor, the application of COX2 inhibitors as adjuvant chemotherapy and combined with chemotherapy drugs has become a new direction in the treatment of lung cancer.

Key words: Lung neoplasms, Drug resistance, Cyclooxygenase2 inhibitors