Abstract: The Ⅳ stage esophageal cancer refers to exist regional lymph nodes and distant organs in patients with metastases. Palliative chemotherapy and radiotherapy is the primary treatment. With the deepening of the clinical study, radiotherapy and chemotherapy are no longer single treatment, chemotherapy combined molecular targeted drugs, chemoradiotherapy and some new treatment methods have been gradually recognized, and especially molecular targeted drugs began to establish its position in the treatment of tumor. Application of various methods individual or combined treatment can effectively prolong survival and improve the quality of life.

Key words: Esophageal neoplasms, Drug therapy, Radiotherapy, Nutritional support