Abstract: Ubiquitinproteasome pathway is one of the primary pathway in intracellular protein degradation, therefore the ubiquitin conjugating enzyme D3 (UbE2D3) which involved in the ubiquitin mineralization process can affect the biological effects accordingly to affect some protein and nucleic acid content and activity. The function that participate in modification and degradation of some cancer factors is vital in tumor cells, and followed by tumor biological behavior changing. Researches show that UbE2D3 correlates with human telomerase reverse transcriptase (hTERT), radiation sensitivity, aggressive, etc in breast cancer.

Key words: Ubiquitination, Neoplasms, Radiation tolerance, Ubiquitinconjugating enzyme E2D3, Human telomerase reverse transcriptase