Journal of International Oncology

Journal of International Oncology ›› 2017, Vol. 44 ›› Issue (2): 139-141.doi: 10.3760/cma.j.issn.1673422X.2017.02.016

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The mechanism of Wnt/β-catenin signaling pathway in glioma invasion

Liu Jing, Wang Xiaogang, Guo Geng, Zhao Yuanli   

  1. Department of Neurosurgery, First Hospital of Shanxi Medical University, Taiyuan 030001, China
  • Online:2017-02-08 Published:2017-01-04
  • Contact: Guo Geng E-mail:guogeng973@163.com
  • Supported by:

    National Natural Science Foundation of China (81201991); China Postdoctoral Science Foundation (2015M571068, 2016T90115); Project Supported by Beijing Postdoctoral Research Foundation (2015ZZ-56, 2016ZZ-43); Natural Science Foundation of Shanxi Province of China (201601D011127); Program for the Outstanding Innovative Teams of Higher Learning Institutions of Shanxi Province(2013-8); Scientific Research Subject of Shanxi Provincial Health Department (201301066)

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Abstract: Invasion of glioma is a complex process with multiple steps and multiple factors, including the inhibition of tumor cell adhesion, the degradation of extracellular matrix, the promotion of tumor cells migration and angiogenesis. The abnormal activation of Wnt/βcatenin signaling pathway is closely related to the invasion of glioma. The study of Wnt/βcatenin pathway affecting invasion mechanism of glioma will provide new ideas and targets for the treatment of glioma.

Key words: Glioma, Neoplasm invasiveness, MicroRNAs, Wnt/β-catenin