Molecular basis and clinical prospect of the miR-34 family for the treatment of gastric cancer

doi:10.3760/cma.j.cn371439-20220927-00134

Abstract

Abstract:

The miR-34 family plays an important role in gastric cancer， and the inactivation or reduced expression of the miR-34 family is detected in gastric cancer cell lines and gastric cancer tissues compared with normal gastric mucosa tissues， indicating it is associated with the occurrence and development of gastric cancer. Studies have shown that miR-34 plays a key role in inhibiting gastric cancer progression by regulating IGF2BP3， survivin， Bcl-2 and epithelial-mesenchymal transition-related pathway， indicating that miR-34 is an important target for gastric cancer treatment. In terms of clinical treatment， miR-34 has not only been proved to have radiochemotherapy sensitization， but also achieved good curative effect in tumor clinical trials. With the emergence of miR-34 vectors targeting gastric cancer， it is possible to use it for gastric cancer treatment. Deep understanding of the molecular basis and clinical efficacy of miR-34 for gastric cancer treatment can help to evaluate the potential of the miR-34 family as a new therapeutic target for gastric cancer.

Key words: Gastric neoplasms, MicroRNAs, miR-34, Epithelial-mesenchymal transition

Jing Wenjun, Zhao Wenwen, Feng Qingqing, Zhao Wenfei, Zhao Lili, Zhang Xue, Wei Hongmei. Molecular basis and clinical prospect of the miR-34 family for the treatment of gastric cancer[J]. Journal of International Oncology, 2022, 49(11): 681-686.

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