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08 February 2017, Volume 44 Issue 2 Previous Issue    Next Issue

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Effect and mechanism of metformin combined with 2-deoxy-D-glucose on proliferation and apoptosis of liver cancer cells XIE Ze-Jun, TANG Yue, ZHOU Jing, DENG Jing-Huan, HE Min, LU Guo-Dong 2017, 44 (2):  81-85.  doi: 10.3760/cma.j.issn.1673422X.2017.02.001 Abstract ( 399 )   PDF (1422KB) ( 1032 )   Save Objective To investigate the combined effect and mechanism of metformin (Met) and 2-deoxy-D-glucose (2DG) on cell proliferation and apoptosis in liver cancer cells HepG2 and Hep3B. Methods Wst-1 reagent was used to determine the antiproliferation effects after treatments with Met and 2DG alone or combined in HepG2 and Hep3B cells. Microscopy was used to observe cell morphological changes after treatments with Met and 2DG alone or combined in HepG2 and Hep3B cells. Cell apoptosis was observed by flow cytometry after treatment of different kinds of drugs. Western blotting was used to analyze the protein expressions of Caspase3, PARP, Mcl-1 of HepG2. Results The survival rate of HepG2 cells in the combination group was (22.48±0.51)%, and compared with the control group (100.00±5.05)%, Met group (80.68±5.10)% and 2DG group (72.56±4.34)%, the differences were statistically significant (P＜0.001; P＜0.001; P=0.001). The survival rate of Hep3B cells in the combination group was (29.16±1.34)%, and compared with the control group (100.00±1.23)%, Met group (59.58±1.92)% and 2DG group (33.87±1.95)%, the differences were statistically significant (P＜0.001; P＜0.001; P=0.001). Microscopy observation showed that combined treatment of Met and 2DG caused less viable adherent cells of HepG2, but more floating dead cells. While the combination group also caused a decrease in the density of Hep3B cells, but did not significantly increase the shedding of cells. The apoptosis of HepG2 cells in the combination group was (39.63±0.21)%, and compared with the control group (7.12±0.14)%, Met group (12.56±0.35)% and 2DG group (15.16±1.93)%, the differences were statistically significant (P＜0.001; P＜0.001; P=0.001). The apoptosis of Hep3B cells in the combination group was (12.58±1.03)%, and compared with the control group (2.82±0.51)% and Met group (8.98±0.86)%, the differences were statistically significant (P＜0.001; P=0.007), but compared with the 2DG group (12.40±1.78)%, the difference was not statistically significant (P=1.000). Furthermore, Western blotting demonstrated that the combined treatment induced evident Caspase-3 activation and poly ADP-ribose polymerase （PARP） cleavages, and decreased expression of Mcl-1. Conclusion The combination of Met and 2DG can effectively inhibit cell proliferation of HepG2 and Hep3B, and induce apoptosis of HepG2 cells. The mechanism may be involved with Caspase-3 activation, cutting PARP substrate and decreasing Mcl-1 protein. Related Articles | Metrics

Evodiamine inhibits apoptosis of human osteosarcoma MG-63 cells by blocking Wnt/β-catenin signaling YUAN Yuan, LI Song-Lin, WANG Zhong-Hua, SHEN Hui-Hua, LI Wu, WANG Wei-Dong 2017, 44 (2):  86-90.  doi: 10.3760/cma.j.issn.1673-422X.2017.02.002 Abstract ( 379 )   PDF (1432KB) ( 1063 )   Save Objective To investigate the effects and mechanism of evodiamine on the proliferation and apoptosis of osteosarcoma MG63 cells. MethodsMG63 cells were cultured with evodiamine for 24 hours, and the cell proliferation was evaluated by methyl thiazolyl tetrazolium (MTT) assay. Cell cycle arrest, apoptosis and intracellular Ca2+ accumulation were evaluated by flow cytometry. BALB/C mice model of osteosarcoma was established to investigate the tumor inhibitory effect of evodiamine on human osteosarcoma. Wnt/β-catenin signaling protein expressions in osteosarcoma cells were detected by Western blotting. ResultsAs concentration of evodiamine increasing (0.25 μmol/L, 0.5 μmol/L, 1.0 μmol/L, 2.0 μmol/L and 4.0 μmol/L), the inhibition rate of MG-63 cells increased ［(4.18±1.26)%, (15.49±2.26)%, (40.55±6.57)%, (49.87±7.69)% and (60.42±8.29)%］. The difference was statistically significant between 2.0 μmol/L group and the control group (t=-2.66, P＜0.05). MG-63 cells were cultured with 2.0 μmol/L evodiamine for 24 hours, and the apoptotic rate was (64.67±8.63)%, the proportion of S phase cells was (85.33±9.31)%, the fluorescence of Ca2+ was 97.33±21.31. The corresponding data of the control group were (4.94±0.81)%, (43.67±8.92)% and 28.67±8.92, the differences were statistically significant (t=-11.90, P＜0.05; t=-7.22, P＜0.05; t=-6.65, P＜0.05). On mice model, the tumor weight of evodiamine group and the control group was (2.15±0.35)g and (4.29±0.49)g respectively, the difference was statistically significant (t=7.95, P＜0.05). Comparing with the control group (1.00±0.00), evodiamine decreased the expression of βcatenin protein (0.72±0.36) and increased the expressions of Bax (1.15±0.27) and Caspase3 (1.46±0.18) protein, and the differences were statistically significant (t=-3.05, P＜0.05; t=-6.42, P＜0.05; t=-5.85, P＜0.05). Conclusion Evodiamine inhibits proliferation and induces apoptosis of human osteosarcoma MG63 cells by blocking Wnt/β-catenin signaling Related Articles | Metrics

Association between blood cadmium burden and clinicopathological characteristics of breast cancer CHEN Jiong-Yu, HUANG Yi-Teng, PENG Yu-Hui, WU Ku-Sheng, ZHOU Li, LIN Xue-Qiong, PENG Lin 2017, 44 (2):  91-94.  doi: 10.3760/cma.j.issn.1673422X.2017.02.003 Abstract ( 422 )   PDF (716KB) ( 929 )   Save Objective To explore the association between blood cadmium levels (BCLs) and clinicopathological characteristics of patients with breast cancer. Methods The clinicopathological characteristics and blood specimens of 186 patients diagnosed with breast cancer were collected between July and December 2009. BCLs were detected by graphitefurnace atomizer absorption spectrophotometer. MannWhitney U test and KruskalWallis H test were used to compare the BCLs of patients with different clinical characteristics. Spearman rank correlation analysis was used to evaluate the relationships between BCLs and some indices of clinical characteristics. Results The BCLs was 2.280(1.579) μg/L. The BCLs were significantly different in patients with different age and body mass index (BMI) (Z=-2.075,P=0.038; χ2=7.429, P=0.023). Also, there were significant differences in different T stages (χ2=10.137, P=0.017), M stages(Z=-2.225, P=0.026), clinical stages (χ2=16.060, P=0.001) and human epidermal growth factor receptor-2 (HER-2) status(Z=-2.072, P=0.038). Excepting for age (r=0.126, P=0.066), BCLs were positively associated with BMI, T stage, M stage,clinical stage and HER2 status (r=0.159, P=0.030; r=0.171, P=0.020; r=0.166, P=0.044; r=0.154, P=0.040; r=0.152, P=0.038).Conclusion The BCLs are associated with some clinicopathological characteristics of breast cancer, and high blood cadmium burden may promote the development of breast cancer. Related Articles | Metrics

Effect of different chemotherapy combined with radiotherapy for the treatment of nonsmall cell lung cancer complicated with type 2 diabetes ZHANG Xiao-Fei, WEI Ya-Qiang 2017, 44 (2):  95-98.  doi: 10.3760/cma.j.issn.1673-422X.2017.02.004 Abstract ( 398 )   PDF (715KB) ( 881 )   Save Objective  To evaluate the effect and the incidence of adverse reaction of different chemotherapy combined with radiotherapy for the treatment of nonsmall cell lung cancer (NSCLC) complicated with type 2 diabetes. MethodsA total of 123 midterm advanced NSCLC patients complicated with type 2 diabetes were randomly divided into A, B, C three groups through the random number generated by computer, and each group was 41 cases. Three groups of patients were treated with threedimensional conformal radiotherapy and synchronous chemotherapy. Group A received gemcitabine and cisplatin, group B received paclitaxel and cisplatin, and group C received pemetrexed and cisplatin. The treatment efficiency, time to tumor progression, median survival time, survival rate and incidence of adverse reaction were observed and compared. ResultsThe total effective rates of group A, B and C were 82.93%, 78.05% and 80.49%, with no statistically significant difference (χ2=0.365, P=0.357). The times to tumor progression of the three groups were (6.54±1.23) months, (5.96±1.27) months, (6.27±1.08) months, with no statistically significant difference (F=1.235,P=0.314); the median survival times of the three groups were (16.54±1.87) months, (15.36±1.25) months, (16.29±2.08) months respectively, with no statistically significant difference (F=2.226, P=0.245); 1year survival rates of the three groups were 80.49%, 82.93%, 85.37% respectively, with no statistically significant difference (χ2=1.234, P=0.665); 2year survival rates were 48.78%, 51.22%, 43.90%, with no statistically significant difference (χ2=2.354, P=0.451). The incidence rates of radioactive pneumonia and bone marrow suppression in group C were 24.39% and 24.39%, those were significantly lower than 31.71%, 53.66% of group B (χ2=18.687, P=0.017; χ2=25.336, P=0.011) and 41.46%, 31.71% of group A (χ2=17.543, P=0.019;χ2=24.358, P=0.013). ConclusionThe clinical efficacy of the three groups are similar, but the incidence rate of adverse reaction in pemetrexed and cisplatin plus radiotherapy group is the lowest. Therefore, pemetrexed plus cisplatin is the safe and effective treatment for the previously untreated patients with NSCLC. Related Articles | Metrics

Analysis of threedimensional conformal radiotherapy for local recurrence of esophageal cancer after definitive radiotherapy WANG Jun, WEI Jie, XIANG Fei, DU Xing-Long, 吕Xing-Wang , YAO Chun-Fei, XU Yuan-Su, LI Shang-Jun, BAO Zong-Ling, DING Ren-Ping 2017, 44 (2):  99-103.  doi: 10.3760/cma.j.issn.1673422X.2017.02.005 Abstract ( 437 )   PDF (783KB) ( 982 )   Save Objective  To evaluate the safety, clinical effect and prognosis of threedimensional conformal radiotherapy (3DCRT) for local recurrent esophageal cancer after definitive radiotherapy. MethodsFrom January 2010 to April 2014, the treatment effects of 46 patients received 3DCRT with local recurrent esophageal cancer after definitive radiotherapy in our hospital were analyzed retrospectively. The Logrank test was used for univariate prognostic analysis, and the Cox regression model was used for multivariate prognostic analysis. ResultsForty patients achieved radiotherapy, 6 patients did not finish radiotherapy. The total effective rate of 3DCRT was 80.0% (32/40). The overall 1 and 2year survival rates were 47.5% (19/40) and 20.0% (8/40). During the radiation therapy, the incidence rates of grade 2+3 acute radiationinduced esophageal toxicity, radiation pneumonitis， hematopoietic toxicity reaction and cardiac toxicity were 47.5% (19 cases), 35.0% (14 cases), 15.0% (6 cases) and 10.0% (4 cases) respectively. There was no treatmentrelated death and no patients experienced any grade 4 toxicities. Univariate analysis results showed the age (χ2=8.432, P=0.015), interval time of radiotherapy (χ2=7.006, P=0.008), radiation dose (χ2=18.718, P=0.000), gross tumor volume (GTV) (χ2=10.121, P=0.006), adjuvant chemotherapy (χ2=5.014, P=0.025), tumor length (χ2=7.391, P=0.025), in field failure (χ2=9.933, P=0.002), tumor control (χ2=14.665, P=0.001) were closely related with prognosis. Diseased region had a tendency to affect overall survival (χ2=5.493, P=0.064). Multivariate analysis results showed that age (χ2=4.759,P=0.029), interval time of radiotherapy (χ2=4.139, P=0.041), GTV (χ2=4.799, P=0.024), tumor control (χ2=4.501, P=0.030) were independent prognostic factors for overall survival. ConclusionTo patients with local recurrent esophageal cancer after definitive radiotherapy, despite acute toxicity rate is high. 3DCRT is an alternative effective method, which can improve the shortterm efficacy. The age, interval time of radiotherapy, GTV and tumor control are prognosis factors. Related Articles | Metrics

Efficacy and safety of pegaspargase and L-asparaginase in the treatment of NK/T-cell lymphoma ZHANG Ke, YU Xiao-Li, HAN Chun-Shan 2017, 44 (2):  104-107.  doi: 10.3760/cma.j.issn.1673422X.2017.02.006 Abstract ( 1145 )   PDF (717KB) ( 1535 )   Save Objective  To compare the clinical efficacy and adverse effects of pegaspargase (PEG-ASP) and L-asparaginase (L-ASP) in the treatment of NK/T-cell lymphoma. Methods  A retrospective analysis was conducted on the clinical data of 46 patients with NK/T-cell lymphoma in Department of Oncology of Hospital of Qingdao Commercial Staff from September 2009 to July 2015. There were 24 patients treated by PEG-ASP combined with GDP (gemcitabine+cisplatin+dexamethasone) as PEG-ASP group, and 22 patients treated by L-ASP combined with GDP as L-ASP group. The efficacy and adverse reactions were compared between the two groups. Results  In the PEG-ASP group, there were 11 patients with complete remission, 7 patients with partial remission, and the complete remission rate and objective response rate were 45.83% and 75.00%. In the L-ASP group, there were 9 patients with complete remission, 6 patients with partial remission, and the complete remission rate and objective response rate were 40.91% and 68.18%. There was no significant difference between the two groups in objective response rate (χ2=0.263, P=0.608). Adverse effects such as myelosuppression (25.00% vs. 22.73%, χ2=0.033, P=0.857), coagulopathy (8.33% vs. 9.10%, χ2=0.008, P=0.927), liver and renal dysfunction (8.33% vs. 18.18%, χ2=0.982, P=0.322), gastrointestinal reaction (41.67% vs. 40.91%, χ2=0.003, P=0.958) were similar in the PEG-ASP group and L-ASP group. But the risk of allergic reaction incurred by PEG-ASP was much lower than L-ASP (4.17% vs. 36.36%), with a significant difference (χ2=7.561, P=0.006). Moreover, the PEG-ASP group had a shorter duration of hospitalization ［(10.04±1.63)d］ than the L-ASP group ［(13.09±2.76)d］, with a significant difference (t=-4.612, P=0.000). Conclusion  The efficacy of PEG-ASP and L-ASP in the treatment of NK/Tcell lymphoma is similar, but the rate of allergic reaction of patients treated with PEG-ASP is significantly lower, and the hospitalization time is significantly shorter, which is worthy of further clinical application. Related Articles | Metrics

Advances of long non-coding RNA UCA1 in cancers YAN Da-Li, CAO Hai-Xia, FENG Ji-Feng 2017, 44 (2):  108-111.  doi: 10.3760/cma.j.issn.1673422X.2017.02.007 Abstract ( 368 )   PDF (712KB) ( 977 )   Save Long non-coding RNA  urothelial carcinoma associated 1 (UCA1) is initially discovered and named in bladder cancer tissue,  which is highly expressed in multi types of tumor tissues, such as bladder cancer, ovarian cancer, lung cancer, suggesting that UCA1 acts as oncogene. UCA1 is confirmed to regulate tumor cell proliferation, apoptosis, invasion and migration, which plays an important role in the occurrence and development of cancers. UCA1 is expected to become a new biomarker for diagnosis, prognosis and drug susceptibility, which may be a promising therapeutic target of cancer. Related Articles | Metrics

Roles of miR296 in tumor progression YIN Jian, ZHU Guang-Hui, DAN Yuan-Zhou, ZHANG Ming 2017, 44 (2):  112-114.  doi: 10.3760/cma.j.issn.1673422X.2017.02.008 Abstract ( 326 )   PDF (702KB) ( 748 )   Save Progression of tumor is a complex process with multiple steps and multiple factors. MicroRNA-296 (miR-296) plays an important role in tumor progression, involved in the proliferation, differentiation, angiogenesis, invasion, metastasis, apoptosis and drug resistance of the tumor cells. Related Articles | Metrics

Competing endogenous RNA and tumor pathological mechanism ZHOU Shu, SHEN Na, CHENG Fan-Jun 2017, 44 (2):  115-117.  doi: 10.3760/cma.j.issn.1673422X.2017.02.009 Abstract ( 606 )   PDF (706KB) ( 1029 )   Save Competing endogenous RNA (ceRNA) is a class of RNA which includes mRNA, pseudogenes, long noncoding RNA (lncRNA), circular RNA (circRNA). ceRNA weakens its inhibitory effect on mRNA translation through competitive binding with shared microRNA (miRNA). Many studies have confirmed that the disorder of ceRNA is closely related to the occurrence of breast cancer, gastric cancer, lymphoma and other tumors. With the improvement of researches, ceRNA may be used as a tumor marker of clinical diagnosis and therapeutic target. Related Articles | Metrics

Research progress of Rab10 in tumor JIA Wei, WANG Wei 2017, 44 (2):  118-121.  doi: 10.3760/cma.j.issn.1673422X.2017.02.010 Abstract ( 597 )   PDF (712KB) ( 1433 )   Save As a member of GTPase Rab family, Rab10 protein is not only involved in vesicle formation, transport, anchoring and fusion process, but also affects the occurrence and development of tumors. Research about the mechanisms of Rab10 in intracellular vesicle transport and tumor may provide a potential target and new idea for the anticancer therapy. Related Articles | Metrics

The role of garlic allyl sulfide in malignant tumor CHEN Xue-Yan, XIONG Ting, LIU Xiao-Wang, CHEN Xiao-Xiao, LI Li-Ding, TIAN Wen, XIE Wei-Quan, TU Jian 2017, 44 (2):  122-124.  doi: 10.3760/cma.j.issn.1673422X.2017.01.011 Abstract ( 398 )   PDF (705KB) ( 1060 )   Save A large number of epidemiological studies have showed that garlic could reduce the incidence and mortality rates of variety cancers such as colon cancer, prostate cancer, stomach cancer, and so on. The main effective anticancer component in garlic was allyl sulfide. Its anticancer mechanisms included regulating signal transduction pathways, blocking the cell cycle, inducing apoptosis and differentiation of the tumor and inhibiting the expressions of oncogenes and so on. Related Articles | Metrics

Differentiation origins of cancer associated fibroblast DONG Yi, YAO Yi, SONG Qi-Bin, LI Ying-Ge 2017, 44 (2):  125-128.  doi: 10.3760/cma.j.issn.1673422X.2017.02.012 Abstract ( 532 )   PDF (713KB) ( 1988 )   Save Cancer associated fibroblast (CAF) is the most important component in the tumor environment, and some researchers even propose that CAF can be the new target in cancer therapy. However what make it difficult for researchers are the various origins of the CAF, such as resident fibroblast, epithelium, endotheliocyte, mesenchymal cell, stem cell and so on. The various origins define their different phenotypes and functions. Further understanding about the origins of the CAF will help us to explore a novel approach for cancer therapy. Related Articles | Metrics

Novel drug targets in radiosensitivity of neoplasms WANG Yan-Jun, JIANG Yong-Xin, LIU Shan, WANG Hong 2017, 44 (2):  129-132.  doi: 10.3760/cma.j.issn.1673422X.2017.02.013 Abstract ( 439 )   PDF (716KB) ( 1732 )   Save Recent studies find a number of promising drug targets which can be applied for increasing tumor radiosensitivity in addition to normal tissue radioprotection, including oxygen free radical scavenger, drug targets in view of DNA damage repair and cell cycle, new targets inhibiting cell death, radioprotection mediated by growth factors, regulation of the cell signaling pathways, angiotensinconverting enzyme inhibitor, radiorestorative chemicals and so on. Related Articles | Metrics

Precision chemotherapy for the treatment of cancers ZHANG Bai-Hong, YUE Hong-Yun 2017, 44 (2):  133-135.  doi: 10.3760/cma.j.issn.1673422X.2017.02.014 Abstract ( 828 )   PDF (705KB) ( 1058 )   Save Precision chemotherapy is the prospective direction of cancer chemotherapy, which involves the selection of the effective chemotherapy regimens based on the chemotherapyrelated genes. Chemotherapyrelated genes include DNA repair genes, drug metabolism enzymes, drug transporters, apoptosisrelated genes and cancerrelated genes. These genes can predict the response and toxicity of chemotherapy, and determine the clinical outcome. Related Articles | Metrics

The mechanism of itraconazole as an anticancer agent FAN Ze-Ying, ZHANG Xiao-Dong, CHEN Hong-Qing 2017, 44 (2):  136-138.  doi: 10.3760/cma.j.issn.1673422X.2017.02.015 Abstract ( 687 )   PDF (706KB) ( 1240 )   Save Itraconazole has potent anticancer activity at the standard therapeutic doses, which is proved in vitro and in vivo preclinical studies, even in active clinical trials. The precise mode of action of itraconazole for its anticancer activity has not been elucidated, however multiple putative mechanisms are proposed, such as antiangiogenesis, inhibition of Hedgehog pathway, autophagy induction and reversal of multidrug resistance. Its high efficacy, known toxicity and wellestablished pharmacokinetics make this generic drug a strong candidate for repurposing as an oncological treatment. Related Articles | Metrics

The mechanism of Wnt/β-catenin signaling pathway in glioma invasion LIU Jing, WANG Xiao-Gang, GUO Geng, ZHAO Yuan-Li 2017, 44 (2):  139-141.  doi: 10.3760/cma.j.issn.1673422X.2017.02.016 Abstract ( 431 )   PDF (708KB) ( 788 )   Save Invasion of glioma is a complex process with multiple steps and multiple factors, including the inhibition of tumor cell adhesion, the degradation of extracellular matrix, the promotion of tumor cells migration and angiogenesis. The abnormal activation of Wnt/βcatenin signaling pathway is closely related to the invasion of glioma. The study of Wnt/βcatenin pathway affecting invasion mechanism of glioma will provide new ideas and targets for the treatment of glioma. Related Articles | Metrics

Expression and mechanism of UCA1 in gastrointestinal tumors ZHAO Yi, YAN Shan-Jun, WANG Qi-Zhi 2017, 44 (2):  142-144.  doi: 10.3760/cma.j.issn.1673422X.2017.02.017 Abstract ( 536 )   PDF (702KB) ( 877 )   Save Urothelial carcinoma associated 1 (UCA1) is a kind of long noncoding RNA (lncRNA), which has no capacities for coding proteins. UCA1 overexpresses in diverse tumors, and plays a pivotal role in initiation and progression of tumors. Researches indicate that UCA1 may function as an oncogene in gastrointestinal tumors, such as gastric cancer, colorectal cancer and hepatocellular cancer, and participate in regulating cell proliferation, metastasis and chemo-resistance. Related Articles | Metrics

MicroRNA let-7 and esophagus cancer SUN Guo-Qing, YANG Xi-Gui, JIANG Chao 2017, 44 (2):  145-147.  doi: 10.3760/cma.j.issn.1673422X.2017.02.018 Abstract ( 329 )   PDF (705KB) ( 814 )   Save The discovery of microRNA (miRNA) has opened up a new train of thought for the diagnosis and treatment of esophagus cancer. let-7 is one of the most widely research of miRNA. In a variety of tumors, the expression of let-7 is downregulated. let-7 can play the role of tumor suppressor gene by targeting to high mobility group A2 (HMGA2) and inhibit the cell proliferation. Recent studies have shown that the lower the degree of differentiation of cells, let-7 expression level is lower. It is expected as a symbol of poorly differentiated tumors. In addition, let-7 and esophagus cancer′s radiation and chemotherapy sensitivity are closely related. Related Articles | Metrics

CXCL5/CXCR2 biological axis in pancreatic cancer HUANG Fan, JING Hong-恩 2017, 44 (2):  148-150.  doi: 10.3760/cma.j.issn.1673422X.2017.02.019 Abstract ( 616 )   PDF (707KB) ( 1174 )   Save The proliferation, progression and metastasis of pancreatic cancer are complicated processes caused by multiple factors. C-X-C motif ligand 5 (CXCL5) can recognize and bind to C-X-C motif receptor 2 (CXCR2), and activate or regulate the expression of signaling pathway by autocrine or paracrine pathway in cells. CXCL5/CXCR2 biological axis plays important roles in proliferation, adhesion, progression, metastasis and prognosis of pancreatic cancer, and is also associated with the angiogenesis and lymphangiogenesis of pancreatic cancer. So, direct or indirect regulation of CXCL5/CXCR2 expression in pancreatic cancer can be effective for target therapy of pancreatic cancer. Related Articles | Metrics

Application of high resolution magnetic resonance imaging in locally advanced rectal cancer YIN Yun-Fei, ZHANG Tao 2017, 44 (2):  151-154.  doi: 10.3760/cma.j.issn.1673422X.2017.02.020 Abstract ( 391 )   PDF (715KB) ( 858 )   Save High resolution magnetic resonance imaging (HRMRI) has become an indispensable tool for multidisciplinary teams addressing locally advanced rectal cancer. Preoperative HRMRI is accurate in predicting tumor stage and poor prognostic features, such as circumferential resection margin and extramural venous invasion, et al. HRMRI is a precise diagnostic tool to select who may benefit from neoadjuvant therapy and to avoid over treatment in those patients who can proceed directly to surgery, thus  achieving better prognosis and quality of life for patients with locally advanced rectal cancer. Related Articles | Metrics