Abstract: The proliferation, progression and metastasis of pancreatic cancer are complicated processes caused by multiple factors. C-X-C motif ligand 5 (CXCL5) can recognize and bind to C-X-C motif receptor 2 (CXCR2), and activate or regulate the expression of signaling pathway by autocrine or paracrine pathway in cells. CXCL5/CXCR2 biological axis plays important roles in proliferation, adhesion, progression, metastasis and prognosis of pancreatic cancer, and is also associated with the angiogenesis and lymphangiogenesis of pancreatic cancer. So, direct or indirect regulation of CXCL5/CXCR2 expression in pancreatic cancer can be effective for target therapy of pancreatic cancer.

Key words: Pancreatic neoplasms, Chemokine CXCL5, Receptor, interleukin-8B