Predictive value of serum inflammatory markers in immunotherapy of non-small cell lung cancer

doi:10.3760/cma.j.cn371439-20211115-00030

Abstract

Abstract:

Immune checkpoint inhibitors (ICIs) can not only prolong the survival time of patients with non-small cell lung cancer (NSCLC) in a short time, but also achieve a lasting response to the tumor. However, there has been significant heterogeneity in the efficacy of ICIs among patients with different types of NSCLC, and there has been still a lack of universal biomarkers to predict the benefit of ICIs treatment. Inflammation has played a definite role in the occurrence and development of tumors, and a variety of inflammatory markers in serum also have become clinical indicators reflecting immune status, such as lactate dehydrogenase, C-reactive protein, serum neutrophils, lymphocytes, platelets and other indicators. These inflammatory markers are easy to obtain and are associated with the prognosis of a variety of solid tumors.

Key words: Carcinoma,non-small-cell lung, Immunotherapy, Inflammatory markers

Luo Hong, Yin Hong, Hu Guangyue, Tao Hong. Predictive value of serum inflammatory markers in immunotherapy of non-small cell lung cancer[J]. Journal of International Oncology, 2022, 49(3): 177-180.

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