Journal of International Oncology ›› 2022, Vol. 49 ›› Issue (9): 550-554.doi: 10.3760/cma.j.cn371439-20220520-00107
• Reviews • Previous Articles Next Articles
Received:
2022-05-20
Revised:
2022-06-10
Online:
2022-09-08
Published:
2022-10-21
Contact:
Hu Qinyong
E-mail:rm001223@whu.edu.cn
Song Jia, Hu Qinyong. Application of TACE combined with molecular targeted therapy and immunotherapy in BCLC B/C hepatocellular carcinoma[J]. Journal of International Oncology, 2022, 49(9): 550-554.
[1] |
Petrick JL, Florio AA, Znaor A, et al. International trends in hepatocellular carcinoma incidence, 1978-2012[J]. Int J Cancer, 2020, 147(2): 317-330. DOI: 10.1002/ijc.32723.
doi: 10.1002/ijc.32723 pmid: 31597196 |
[2] |
Kudo M, Kawamura Y, Hasegawa K, et al. Management of hepatocellular carcinoma in Japan: JSH consensus statements and recommendations 2021 update[J]. Liver Cancer, 2021, 10(3): 181-223. DOI: 10.1159/000514174.
doi: 10.1159/000514174 pmid: 34239808 |
[3] |
European Association for the Study of the Liver. EASL clinical practice guidelines: management of hepatocellular carcinoma[J]. J Hepatol, 2018, 69(1): 182-236. DOI: 10.1016/j.jhep.2018.03.019.
doi: S0168-8278(18)30215-0 pmid: 29628281 |
[4] |
Li QJ, He MK, Chen HW, et al. Hepatic arterial infusion of oxaliplatin, fluorouracil, and leucovorin versus transarterial chemoembolization for large hepatocellular carcinoma: a randomized phase Ⅲ trial[J]. J Clin Oncol, 2022, 40(2): 150-160. DOI: 10.1200/JCO.21.00608.
doi: 10.1200/JCO.21.00608 |
[5] |
Raoul JL, Forner A, Bolondi L, et al. Updated use of TACE for hepatocellular carcinoma treatment: how and when to use it based on clinical evidence[J]. Cancer Treat Rev, 2019, 72: 28-36. DOI: 10.1016/j.ctrv.2018.11.002.
doi: 10.1016/j.ctrv.2018.11.002 |
[6] |
Adamek A, Kasprzak A. Insulin-like growth factor (IGF) system in liver diseases[J]. Int J Mol Sci, 2018, 19(5): 1308. DOI: 10.3390/ijms19051308.
doi: 10.3390/ijms19051308 |
[7] |
Fan SKY, Li B, Chen Q, et al. Impact of interventional oncology therapies on tumor microenvironment and strategies to enhance their efficacy[J]. AJR Am J Roentgenol, 2018, 210(3): 648-656. DOI: 10.2214/AJR.16.17677.
doi: 10.2214/AJR.16.17677 |
[8] |
李相成, 王宏伟, 李长贤. 肝癌综合治疗的现状与展望[J]. 中华消化外科杂志, 2018, 17(5): 433-436. DOI: 10.3760/cma.j.issn.1673-9752.2018.05.004.
doi: 10.3760/cma.j.issn.1673-9752.2018.05.004 |
[9] |
Chang Y, Jeong SW, Young Jang J, et al. Recent updates of transarterial chemoembolilzation in hepatocellular carcinoma[J]. Int J Mol Sci, 2020, 21(21): 8165. DOI: 10.3390/ijms21218165.
doi: 10.3390/ijms21218165 |
[10] |
Niu M, Yi M, Li N, et al. Advances of targeted therapy for hepatocellular carcinoma[J]. Front Oncol, 2021, 11: 719896. DOI: 10.3389/fonc.2021.719896.
doi: 10.3389/fonc.2021.719896 |
[11] |
Llovet JM, Kelley RK, Villanueva A, et al. Hepatocellular carcinoma[J]. Nat Rev Dis Primers, 2021, 7(1): 6. DOI: 10.1038/s41572-020-00240-3.
doi: 10.1038/s41572-020-00240-3 pmid: 33479224 |
[12] |
Lencioni R, Llovet JM, Han G, et al. Sorafenib or placebo plus TACE with doxorubicin-eluting beads for intermediate stage HCC: the SPACE trial[J]. J Hepatol, 2016, 64(5): 1090-1098. DOI: 10.1016/j.jhep.2016.01.012.
doi: S0168-8278(16)00018-0 pmid: 26809111 |
[13] |
Meyer T, Fox R, Ma YT, et al. Sorafenib in combination with transarterial chemoembolisation in patients with unresectable hepatocellular carcinoma (TACE 2): a randomised placebo-controlled, double-blind, phase 3 trial[J]. Lancet Gastroenterol Hepatol, 2017, 2(8): 565-575. DOI: 10.1016/S2468-1253(17)30156-5.
doi: 10.1016/S2468-1253(17)30156-5 |
[14] |
Park JW, Kim YJ, Kim DY, et al. Sorafenib with or without concurrent transarterial chemoembolization in patients with advanced hepatocellular carcinoma: the phase Ⅲ STAH trial[J]. J Hepatol, 2019, 70(4): 684-691. DOI: 10.1016/j.jhep.2018.11.029.
doi: 10.1016/j.jhep.2018.11.029 |
[15] |
Kudo M, Ueshima K, Ikeda M, et al. Randomised, multicentre prospective trial of transarterial chemoembolisation (TACE) plus sorafenib as compared with TACE alone in patients with hepatocellular carcinoma: TACTICS trial[J]. Gut, 2020, 69(8): 1492-1501. DOI: 10.1136/gutjnl-2019-318934.
doi: 10.1136/gutjnl-2019-318934 pmid: 31801872 |
[16] |
Wu FX, Chen J, Bai T, et al. The safety and efficacy of transarterial chemoembolization combined with sorafenib and sorafenib mono-therapy in patients with BCLC stage B/C hepatocellular carcinoma[J]. BMC Cancer, 2017, 17(1): 645. DOI: 10.1186/s12885-017-3545-5.
doi: 10.1186/s12885-017-3545-5 |
[17] |
Kudo M, Finn RS, Qin S, et al. Lenvatinib versus sorafenib in first-line treatment of patients with unresectable hepatocellular carcinoma: a randomised phase 3 non-inferiority trial[J]. Lancet, 2018, 391(10126): 1163-1173. DOI: 10.1016/S0140-6736(18)30207-1.
doi: S0140-6736(18)30207-1 pmid: 29433850 |
[18] |
Ando Y, Kawaoka T, Amioka K, et al. Efficacy and safety of lenvatinib-transcatheter arterial chemoembolization sequential therapy for patients with intermediate-stage hepatocellular carcinoma[J]. Oncology, 2021, 99(8): 507-517. DOI: 10.1159/000515865.
doi: 10.1159/000515865 |
[19] |
Al-Salama ZT, Syed YY, Scott LJ. Lenvatinib: a review in hepatocellular carcinoma[J]. Drugs, 2019, 79(6): 665-674. DOI: 10.1007/s40265-019-01116-x.
doi: 10.1007/s40265-019-01116-x pmid: 30993651 |
[20] |
Kudo M. Lenvatinib may drastically change the treatment landscape of hepatocellular carcinoma[J]. Liver Cancer, 2018, 7(1): 1-19. DOI: 10.1159/000487148.
doi: 10.1159/000487148 pmid: 29662829 |
[21] |
Fathi Maroufi N, Rashidi MR, Vahedian V, et al. Therapeutic potentials of apatinib in cancer treatment: possible mechanisms and clinical relevance[J]. Life Sci, 2020, 241: 117106. DOI: 10.1016/j.lfs.2019.117106.
doi: 10.1016/j.lfs.2019.117106 |
[22] |
Chen S, Yu W, Zhang K, et al. Comparison of the efficacy and safety of transarterial chemoembolization with and without apatinib for the treatment of BCLC stage C hepatocellular carcinoma[J]. BMC Cancer, 2018, 18(1): 1131. DOI: 10.1186/s12885-018-5081-3.
doi: 10.1186/s12885-018-5081-3 pmid: 30453925 |
[23] |
Yang Z, Chen G, Cui Y, et al. The safety and efficacy of TACE combined with apatinib on patients with advanced hepatocellular carcinoma: a retrospective study[J]. Cancer Biol Ther, 2019, 20(3): 321-327. DOI: 10.1080/15384047.2018.1529099.
doi: 10.1080/15384047.2018.1529099 pmid: 30332553 |
[24] |
Kan X, Liang B, Zhou G, et al. Transarterial chemoembolization combined with apatinib for advanced hepatocellular carcinoma: a propensity score matching analysis[J]. Front Oncol, 2020, 10: 970. DOI: 10.3389/fonc.2020.00970.
doi: 10.3389/fonc.2020.00970 pmid: 32733791 |
[25] |
Chiang CL, Chan SK, Lee SF, et al. First-line atezolizumab plus bevacizumab versus sorafenib in hepatocellular carcinoma: a cost-effectiveness analysis[J]. Cancers (Basel), 2021, 13(5): 931. DOI: 10.3390/cancers13050931.
doi: 10.3390/cancers13050931 |
[26] |
Sangro B, Sarobe P, Hervás-Stubbs S, et al. Advances in immunotherapy for hepatocellular carcinoma[J]. Nat Rev Gastroenterol Hepatol, 2021, 18(8): 525-543. DOI: 10.1038/s41575-021-00438-0.
doi: 10.1038/s41575-021-00438-0 pmid: 33850328 |
[27] |
Zongyi Y, Xiaowu L. Immunotherapy for hepatocellular carcinoma[J]. Cancer Lett, 2020, 470: 8-17. DOI: 10.1016/j.canlet.2019.12.002.
doi: S0304-3835(19)30603-2 pmid: 31811905 |
[28] |
Wu Y, Lin H, You X, et al. Immune checkpoint blockade in Chinese patients with hepatocellular carcinoma: characteristics and particularity[J]. Front Oncol, 2022, 12: 764923. DOI: 10.3389/fonc.2022.764923.
doi: 10.3389/fonc.2022.764923 |
[29] |
Mikhail AS, Negussie AH, Mauda-Havakuk M, et al. Drug-eluting embolic microspheres: state-of-the-art and emerging clinical applications[J]. Expert Opin Drug Deliv, 2021, 18(3): 383-398. DOI: 10.1080/17425247.2021.1835858.
doi: 10.1080/17425247.2021.1835858 pmid: 33480306 |
[30] |
Duffy AG, Ulahannan SV, Makorova-Rusher O, et al. Tremelimu-mab in combination with ablation in patients with advanced hepatocellular carcinoma[J]. J Hepatol, 2017, 66(3): 545-551. DOI: 10.1016/j.jhep.2016.10.029.
doi: 10.1016/j.jhep.2016.10.029 |
[31] |
Pinato DJ, Cole T, Bengsch B, et al. A phase Ⅰb study of pembrolizumab following trans-arterial chemoembolization (TACE) in hepatocellular carcinoma (HCC): PETAL[J]. Ann Oncol, 2019, 30(Supplement 5): v288. DOI: 10.1093/annonc/mdz247.076.
doi: 10.1093/annonc/mdz247.076 |
[32] |
Greten TF, Mauda-Havakuk M, Heinrich B, et al. Combined locoregional-immunotherapy for liver cancer[J]. J Hepatol, 2019, 70(5): 999-1007. DOI: 10.1016/j.jhep.2019.01.027.
doi: S0168-8278(19)30074-1 pmid: 30738077 |
[33] |
Kloeckner R, Galle PR, Bruix J. Local and regional therapies for hepatocellular carcinoma[J]. Hepatology, 2021, 73(Suppl 1): 137-149. DOI: 10.1002/hep.31424.
doi: 10.1002/hep.31424 |
[34] |
Sparchez Z, Radu P, Bartos A, et al. Combined treatments in hepatocellular carcinoma: time to put them in the guidelines?[J]. World J Gastrointest Oncol, 2021, 13(12): 1896-1918. DOI: 10.4251/wjgo.v13.i12.1896.
doi: 10.4251/wjgo.v13.i12.1896 |
[35] |
Yang F, Xu GL, Huang JT, et al. Transarterial chemoembolization combined with immune checkpoint inhibitors and tyrosine kinase inhibitors for unresectable hepatocellular carcinoma: efficacy and systemic immune response[J]. Front Immunol, 2022, 13: 847601. DOI: 10.3389/fimmu.2022.847601.
doi: 10.3389/fimmu.2022.847601 |
[36] |
Wu JY, Yin ZY, Bai YN, et al. Lenvatinib combined with anti-PD-1 antibodies plus transcatheter arterial chemoembolization for unresectable hepatocellular carcinoma: a multicenter retrospective study[J]. J Hepatocell Carcinoma, 2021, 8: 1233-1240. DOI: 10.2147/JHC.S332420.
doi: 10.2147/JHC.S332420 |
[37] |
Yang F, Xu GL, Huang JT, et al. Transarterial chemoembolization combined with immune checkpoint inhibitors and tyrosine kinase inhibitors for unresectable hepatocellular carcinoma: efficacy and systemic immune response[J]. Front Immunol, 2022, 13: 847601. DOI: 10.3389/fimmu.2022.847601.
doi: 10.3389/fimmu.2022.847601 |
[38] |
Llovet JM, Vogel A, Madoff DC, et al. Randomized phase 3 LEAP-012 study: transarterial chemoembolization with or without lenvatinib plus pembrolizumab for intermediate-stage hepatocellular carcinoma not amenable to curative treatment[J]. Cardiovasc Intervent Radiol, 2022, 45(4): 405-412. DOI: 10.1007/s00270-021-03031-9.
doi: 10.1007/s00270-021-03031-9 pmid: 35119481 |
[1] | Yang Mi, Bie Jun, Zhang Jiayong, Deng Jiaxiu, Tang Zuge, Lu Jun. Analysis of the efficacy and prognosis of neoadjuvant therapy for locally advanced resectable esophageal cancer [J]. Journal of International Oncology, 2024, 51(6): 332-337. |
[2] | Xu Fenglin, Wu Gang. Research progress of EBV in tumor immune microenvironment and immunotherapy of nasopharyngeal carcinoma [J]. Journal of International Oncology, 2024, 51(6): 359-363. |
[3] | Wang Ying, Liu Nan, Guo Bing. Advances of antibody-drug conjugate in the therapy of metastatic breast cancer [J]. Journal of International Oncology, 2024, 51(6): 364-369. |
[4] | Gao Fan, Wang Ping, Du Chao, Chu Yanliu. Research progress on intestinal flora and non-surgical treatment of the colorectal cancer [J]. Journal of International Oncology, 2024, 51(6): 376-381. |
[5] | Fan Zhipeng, Yu Jing, Hu Jing, Liao Zhengkai, Xu Yu, Ouyang Wen, Xie Conghua. Predictive value of changes in inflammatory markers for prognosis in patients with advanced non-small cell lung cancer treated with the first-line immunotherapy plus chemotherapy [J]. Journal of International Oncology, 2024, 51(5): 257-266. |
[6] | Wang Peixin, Zhao Jun, Xu Shihong, Jiang Zhaoyang, Wang Xiaoqiang, Yang Hongjuan. Progress of ferroptosis-related mechanisms in osteosarcoma [J]. Journal of International Oncology, 2024, 51(5): 308-311. |
[7] | Yang Hao, Shi Guidong, Zhang Chengcheng, Zhang Yue, Zhang Liwen, Fu Maoyong. Comparison of efficacy and safety between sintilimab and tislelizumab in neoadjuvant therapy for advanced esophageal squamous cell carcinoma [J]. Journal of International Oncology, 2024, 51(4): 210-216. |
[8] | Sa Qiang, Xu Hangcheng, Wang Jiayu. Advances in immunotherapy for breast cancer [J]. Journal of International Oncology, 2024, 51(4): 227-234. |
[9] | Yang Zhi, Lu Yiqiao, Gu Huayan, Ding Jialing, Guo Guilong. Research progress of tumor microenvironment mediated drug resistance in targeted therapy of breast cancer [J]. Journal of International Oncology, 2024, 51(4): 235-238. |
[10] | Sun Weiwei, Yao Xuemin, Wang Pengjian, Wang Jing, Jia Jinghao. Exploration of prognostic factors and nomogram construction for advanced non-small cell lung cancer treated with immunotherapy based on hematologic indexes [J]. Journal of International Oncology, 2024, 51(3): 143-150. |
[11] | Liu Yulan, Jing Haiyan, Sun Jing, Song Wei, Sha Dan. Advances in predicting efficacy and prognostic markers of immunotherapy for gastric cancer [J]. Journal of International Oncology, 2024, 51(3): 175-180. |
[12] | Cui Tenglu, Lyu lu, Sun Pengfei. Application of radiotherapy combined with immunotherapy in the treatment of head and neck squamous cell carcinoma [J]. Journal of International Oncology, 2023, 50(9): 548-552. |
[13] | Huang Hui, Ding Jianghua. Advances in targeting FGFR2 for treatment of advanced cholangiocarcinoma [J]. Journal of International Oncology, 2023, 50(9): 569-573. |
[14] | Guo Ciliang, Jiang Chunping, Wu Junhua. Gut microbiome and tumor immunotherapy [J]. Journal of International Oncology, 2023, 50(7): 432-436. |
[15] | Li Qingshan, Xie Xin, Zhang Nan, Liu Shuai. Research progress on the application of combining radiotherapy and systemic therapy in breast cancer [J]. Journal of International Oncology, 2023, 50(6): 362-367. |
Viewed | ||||||
Full text |
|
|||||
Abstract |
|
|||||