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Journal of International Oncology

Table of Content

    08 October 2015, Volume 42 Issue 10 Previous Issue    Next Issue
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    Sorafenib inhibits tumor growth through modulating vasculogenic mimicry in a hepatocellular carcinoma xenograft model
    Zhang Yueying*, Wang Zhaopeng, Wang Zhaoxia, Jia Qing, Wang Hengxiao, Jiang Guosheng, Zhang Weidong
    2015, 42 (10):  721-725.  doi: 10.3760/cma.j.issn.1673-422X.2015.10.001
    Abstract ( 384 )   PDF (1378KB) ( 1461 )   Save
    Objective To investigate the effects and the mechanism of sorafenib on hepatocellular carcinoma growth and vasculogenic mimicry (VM) in mice. Methods A subcutaneous implantation mouse model of human hepatocellular carcinoma (HCC) HepG2 cells were established. Mice inoculated with HepG2 cells were randomly divided into the treatment group (sorafenib 30 mg·kg-1·d-1) and the control group by using of paired comparison method. Growth of established tumor xenografts was monitored at least twice weekly by vernier caliper measurements. VM was assessed by immunohistochemical assay and periodic acid schiff reaction (PAS) histochemical doublestaining. The expressions of HIF-1α, VEGFA, VEGFR-1 and MMP-2 in tumor tissues were also assessed by immunohistochemical assay, Western blotting and realtime quantitative PCR. Results The tumor volume in the sorafenib group was obviously decreased compared with the control group (809.69 mm3±208.71 mm3 vs 1 678.00 mm3±313.29 mm3), with a statistically significant difference (t=6.103, P=0.030). Haematoxylin and eosin (HE) staining showed that tumor tissues treated with sorafenib were characterized by obvious necrosis, but there were not the same cases in the control group. Sorafenib group significantly reduced the number of tumor functional vessel in HepG2 xenografts compared with the control group, as assessed by tumor vasculature uptake of DiOC7 (4.77±0.15 vs 8.44±0.68, t=9.192, P=0.013). The number of VM was significantly decreased by sorafenib (1.04±0.46 vs 2.66±0.42, t=4.510, P=0.041). Relative to controls, CD31positive vessels decreased after treatments (3.42±0.10 vs 1.26±0.14), with a statistically significant difference (t=21.580, P=0.002). Compared with the control group, the protein levels of HIF-1α (0.65±0.03 vs 1.00±0.00), VEGFA (0.51±0.02 vs 1.00 ±0.00), VEGFR-1 (0.45±0.04 vs 1.00±0.00) and MMP-2 (0.69±0.02 vs 1.00±0.00) were significantly decreased in the sorafenib group (t=19.650, P=0.003; t=40.493, P=0.000; t=23.429, P=0.002; t=26.071, P=0.002). Compared with the control group, the mRNA levels of HIF-1α (0.78±0.05 vs 1.00±0.00), VEGFA (0.52±0.05 vs 1.00±0.00), VEGFR-1 (0.45±0.02 vs 1.00±0.00) and MMP-2 (0.71±0.02 vs 1.00±0.00) were also significantly decreased in sorafenib group (t=6.840, P=0.021; t=27.710, P=0.001; t=62.740, P=0.000; t=23.850, P=0.002). Conclusion Sorafenib can inhibit the tumor growth and VM channels formation, which may be related with the HIF1α and VEGFA/VEGFR-1 signaling pathway.
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    Therapeutic effect and prognostic factors for patients with mucoepidermoid carcinoma of parotid gland
    Wei Cunzhi, Cai Defeng, Qu Jinwen, Xiao Shiqiang, Wang Jianhong
    2015, 42 (10):  726-729.  doi: 10.3760/cma.j.issn.1673-422X.2015.10.002
    Abstract ( 863 )   PDF (881KB) ( 1708 )   Save
    Objective To study the therapeutic effect of adjuvant chemotherapy and radiotherapy after operation in patients with mucoepidermoid carcinoma of parotid gland, and to screen the indicators ralated to the prognosis of tumor. Methods Eighty patients with mucoepidermoid carcinoma of parotid gland in First People′ Hospital of Yibin of Sichuan Province from January 2005 to December 2009 were analysed retrospectively in our research. We studied the survival of patients who were treated wtih simple operation(30 cases) or postoperative adjuvant therapy(50 cases). Then we further analyzed the relationships between the prognosis of the patients and some variables (age, gender, smoking, alcohol drinking, lymph node metastasis, distant organ metastasis, treatment method, differentiation degree and T grading). Results Kaplan-Meier survival curves showed that patients with postoperative adjuvant therapy had longer PFS and OS than those without adjuvant therapy (94.4 months vs 69.3 months; 114.9 months vs 96.7 months), with statistical significance (χ2=11.246, P=0.001; χ2=15.803, P=0.001). COX univariate analysis showed that gender (χ2=22.346, P=0.000), smoking (χ2=7.891, P=0.041), lymph node metastasis (χ2=12.371, P=0.005), distant organ metastasis (χ2=9.813, P=0.002), treatment method (χ2=25.261, P=0.000), differentiation degree (χ2=4.361, P=0.006) and T grading (χ2=5.336, P=0.014) were related to the PFS of patients. COX multivariate analysis showed that lymph node metastasis (χ2=11.003, RR=2.827, 95%CI: 1.9653.851, P=0.011), distant organ metastasis (χ2=7.611, RR=0.472, 95%CI: 0.2400.775, P=0.016), treatment method (χ2=24.542, RR=5.390, 95%CI: 3.5859.602, P=0.000), degree of differentiation (χ2=3.221, RR=2.118, 95%CI: 1.8454.719, P=0.009) and T grading (χ2=4.336, RR=0.804, 95%CI: 0.6810.916, P=0.024) were related to the PFS of patients. COX univariate analysis showed that smoking (χ2=4.551, P=0.008), alcohol drinking (χ2=11.742, P=0.048), lymph node metastasis (χ2=14.886, P=0.009), distant organ metastasis (χ2=6.713, P=0.005), treatment method (χ2=22.411, P=0.000), degree of differentiation (χ2=8.116, P=0.012) and T grading (χ2=14.443, P=0.035) were related to the OS of patients. COX multivariate analysis showed that lymph node metastasis (χ2=11.711, RR=2.985, 95%CI: 1.5213.999, P=0.005), distant organ metastasis (χ2=5.390, RR=0.400, 95%CI:0.2010.793, P=0.009), treatment method (χ2=19.327, RR=5.086, 95%CI: 3.2418.006, P=0.000), degree of differentiation (χ2=7.084, RR=2.301, 95%CI: 1.9084.503, P=0.001) and T grading (χ2=13.229, RR=0.561, 95%CI: 0.3480.867, P=0.040) were related to the OS of patients. Conclusion Adjuvant radiation and chemotherapy can obviously prolong the PFS and OS for the patients with mucoepidermoid carcinoma of parotid gland. Lymph node metastasis, distant organ metastasis, treatment method, differentiation degree and T grading can greatly influence the prognosis of patients with mucoepidermoid carcinoma of parotid gland, which can be used as independent prognostic indicators for the patients with mucoepidermoid carcinoma of parotid gland.
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    Expressions of MMP-7 and bFGF and their correlations with tumor interstitial microvascular density and cancer metastasis in NSCLC
    Li Daosheng, Ban Yuanyuan
    2015, 42 (10):  730-733.  doi: 10.3760/cma.j.issn.1673-422X.2015.10.003
    Abstract ( 327 )   PDF (714KB) ( 1377 )   Save
    Objective To investigate the expressions of matrix metalloproteinase-7 （MMP-7）, basic fibroblast growth factor （bFGF） in NSCLC, and to elucidate the correlations among MMP7, bFGF and MVD, as well as their relationships with cancer metastasis in NSCLC. Methods The expressions of MMP-7, bFGF and MVD were detected by immunohistochemical SP method in 80 cases of NSCLC and 40 cases of normal lung tissue, compare the expression of MMP-7 and bFGF in NSCLC and normal lung tissue, and then invest the relationship between their expression and lymph node metastasis in NSCLC. The MVD was investigated within the CD34 positive slides,  check the relationship between MVD and the expression of MMP-7 , bFGF in NSCLC, and also its relationship with histology type, differentiation degree, lymph node metastasis and TNM stage. Results The positive rates of MMP-7 and bFGF were significantly higher in NSCLC than those in normal lung tissue (70.0% vs 12.5%, χ2＝35.276, P＝0.000; 65.0% vs 10.0%, χ2＝32.411, P＝0.000). The positive rates of MMP-7 and bFGF were also significantly higher in group with lymph node metastasis compared to those group without lymph node metastasis (83.0% vs 51.5%, χ2＝9.139, P＝0.003; 80.9% vs 42.4%, χ2=12.584, P＝0.000). The numbers of MVD were significantly higher in cases with MMP-7 and bFGF positive expressions than those in cases with MMP-7 and bFGF negative expressions (46.78±11.11 vs 31.12±7.62, t＝5.831, P＝0.000; 45.05±10.97 vs 34.77±8.56, t＝5.364, P＝0.000). The number of MVD in group with lymph node metastasis was also significantly higher than that in group without lymph node metastasis (61.32±21.61 vs 40.52±18.31, t＝3.865, P＝0.008). The number of MVD in staging Ⅲ-Ⅳ group was significantly higher than that in stagingⅠ-Ⅱgroup ( 55.28±15.64 vs 41.73±16.48, t＝2.531, P＝0.013). Conclusion The expression levels of MMP-7 and bFGF in NSCLC are high, and the positive rates of MMP-7 and bFGF are correlated with the lymphnode metastasis. The numbers of MVD are significantly higher in cases with MMP7 and bFGF positive expressions than those in cases with MMP7 and bFGF negative expressions. MVD is correlated with lymph node metastasis and the TNM stage. It suggests that the expressions of MMP7, bFGF and MVD may involve in the invasion and metastasis of NSCLC.
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    Diagnostic analysis of endoscopic Lugol solution staining combined with narrow band imaging for esophageal cancer and precancerous lesions
    Yang Bin, Chen Yan
    2015, 42 (10):  734-737.  doi: 10.3760/cma.j.issn.1673-422X.2015.10.004
    Abstract ( 394 )   PDF (711KB) ( 1274 )   Save
    Objective To investigate the diagnostic value of Lugol solution staining combined with narrow band imaging (NBI) for esophageal cancer and precancerous lesions. Methods From December 2013 to December 2014, 187 patients who were with suspicious esophageal lesions and stained with Lugol solution under endoscopy were selected as control group, while from January 2015 to June 2015, 124 patients who were with suspicious esophageal lesions and examined with Lugol solution staining and NBI under endoscopy were selected as observation group. The sensitivity, specificity and accuracy between the two groups were compared and analyzed. Results One hundred and four cases (75.0%) were found among observation group, which was higher than 93 cases (55.6%) among control group (χ2=12.07, P<0.01). The total detection rates of esophageal cancer and high grade intraepithelial neoplasia (HGN) were 29.0% and 17.7% in observation group respectively, which were higher than 18.2% and 6.4% in control group (χ2= 4.15, P=0.04; χ2=8.54, P<0.01). The Kappa value in observation group was 0.55, which was higher than 0.36 in control group. The sensitivity and accuracy in observation group were 89.9% and 82.3% respectively, which were significantly higher than 71.8% and 68.4% in control group (χ2=9.79, P<0.01; χ2=7.38, P<0.01). Conclusion The sensitivity and accuracy of endoscopic Lugol solution staining combined with NBI for esophageal cancer and precancerous lesions are higher than Lugol solution staining, and it is worthy to popularize the application of Lugol solution staining combined with NBI in diagnosing esophageal cancer and precancerous lesions.
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    Evaluation of liver function after G4 cyberknife treatment of large hepatocellular carcinoma
    Zhang Jinlong, Xue Hui, Liang Xuefeng, Wan Zhiqing, Chang Xiaoyun, Zhang Jian, Han Ping, Li Yu
    2015, 42 (10):  738-742.  doi: 10.3760/cma.j.issn.1673-422X.2015.10.005
    Abstract ( 559 )   PDF (716KB) ( 1370 )   Save
    Objective To explore the influence of G4 cyberknife treatment of large hepatocellular carcinoma on liver function, and to evaluate its treatment safety. Methods Sixtythree large liver cancer patients treated with routine G4 cyberknife treatment were retrospectively analyzed, and then statistical analysis of the difference in liver function before and after treatment was conducted.  Results After G4 cyberknife treatment of 12 months, the levels of ALT, ALP, TBIL, PA were respectively 23.00 U/L, 111.00 U/L, 13.70 μmol/L, (81.87±13.94)%. Compared with the levels before treatment ［28.00 U/L, 32.00 U/L, 11.30 μmol/L, (86.07±14.07)%］, there were no significant differences found (Z=-1.677， P=0.094； Z=-0.504， P=0.614； Z=-1.945， P=0.053; t=1.271, P=0.213). The level of ambumin was (34.84±4.75)g/L at 12 months after treatment, which decreased and the difference compared with the level before treatment ［(37.45±4.14)g/L］ was significant (t=3.357, P=0.002). The ChildPugh grade was 5.80±1.17 respectively at the time points of 12 months after treatment, and no significant difference was found compared with the ChildPugh grade before treatment (5.48±0.81, t=-1.668, P=0.106). Conclusion G4 cyberknife treatment does not cause liver injury. It is safe and reliable in large liver cancer treatment. So, it is worth widely clinical popularizing.
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    Meta-analysis of the association between GSTT1 and the susceptibility to colorectal cancer among Chinese population
    YANG Tian-Ning, ZHAO Da, MA Shou-Cheng, GUAN Quan-Lin
    2015, 42 (10):  743-746.  doi: 10.3760/cma.j.issn.1673-422X.2015.10.006
    Abstract ( 445 )   PDF (1133KB) ( 1357 )   Save
    Objective To assess the association between glutathione S-transferase T1 （GSTT1) gene and the susceptibility of colorectal cancer among Chinese population. Methods Clinical controlled trials of the association between GSTT1 and the susceptibility of colorectal cancer among Chinese population were searched in PubMed, EMBase, Cochrane Library, China Biology Medicine disc, VIP database, China National Knowledge Infrastructure and Wanfang database. According to the inclusion and exclusion criteria, data extraction and quality assessment were done by two researchers independently. Outcomes were pooled with RevMan 5.1. Results 326 studies were found and 10 clinical controlled trails including 2 983 cases of colorectal cancer and 4 386 cases of healthy objects were included in this analysis. The results of Metaanalysis showed that the lack of GSTT1 gene is associated with colorectal cancer susceptibility (RR=1.11， 95%CI： 1.061.17， Z=4.26, P<0.000 1). Conclusion The loss of GSTT1 increase the risk of colorectal cancer among Chinese population.
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    Expression and significance of HA117 gene in tumor
    Wang Hong, Jia Xiuhong
    2015, 42 (10):  747-749.  doi: 10.3760/cma.j.issn.1673-422X.2015.10.007
    Abstract ( 464 )   PDF (707KB) ( 1477 )   Save
    HA117, as a multiple drug resistance（MDR） gene, has recently been discovered. It may mediate the MDR of tumor through Bcl2 antiapoptotic pathways. HA117 gene exists high expression in leukemia, lymphoma, breast cancer, neuroblastoma, colon adenocarcinoma and so on， and its overexpression is closely associated with the MDR and poor prognosis of these tumors.
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    Mechanism of Raf kinase inhibitor protein down-regulation in cancer
    Wang Yun, Li Yuhong
    2015, 42 (10):  750-752.  doi: 10.3760/cma.j.issn.1673-422X.2015.10.008
    Abstract ( 366 )   PDF (706KB) ( 1240 )   Save
    Raf -kinase inhibiting protein (RKIP) plays a vital role in various physiological processes and participates in multiple signaling pathways, with a close releationgship with tumor. The mechanism of RKIP down-regulation in neoplasms includes transcriptional regulation, methylation, acetylation, histone modification, microRNA regulation and NF-κB/Snail/RKIP loop regulation.
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    Molecular mechanism and application of translationally controlled tumor protein in tumor targeting therapy
    Han Yujing, Li Yilan, Ning Xuelian, Sun Huiying, Zhou Chunshui.
    2015, 42 (10):  753-755.  doi: 10.3760/cma.j.issn.1673-422X.2015.10.009
    Abstract ( 374 )   PDF (705KB) ( 1431 )   Save
    Translationally controlled tumor protein (TCTP) is a small protein highly conserved in a variety of eukaryotic species. TCTP is overexpressed in various tumor cells and has been implicated in the regulation of cellular processes including apoptosis, DNA repair and drug resistance. By reviewing the recent progress of TCTP research, TCTP is becoming an important regulator of DNA repair and a new molecular target for tumor therapy.
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    Overview of molecular diagnosis and targeted treatment of tumor
    Zheng Xiaowen， Wang Yuping， Zhou Yongning
    2015, 42 (10):  756-758.  doi: 10.3760/cma.j.issn.1673-422X.2015.10.010
    Abstract ( 404 )   PDF (703KB) ( 1274 )   Save
    The occurrence and outcome of cancer is related to the involved gene； Detecting the expression of gene in body by the realtime PCR technology can diagnose and evaluate the prognosis of patients early. Through analyzing the abnormal genes and molecular, designing and studying the targeted drugs can achieve the therapeutic effect of "steady, accurate, relentless", at the same time to reduce side effects and to improve the quality of life.
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    Progress of phage display technology in cancer
    Luo Junqian, Dong Suming, Zhang Fan, Yang Xiaofeng
    2015, 42 (10):  759-761.  doi: 10.3760/cma.j.issn.1673-422X.2015.10.011
    Abstract ( 380 )   PDF (706KB) ( 1502 )   Save
    Phage display technology describes a genetic engineering technique in which a library of peptide or protein variants is expressed on the outside of a phage virion, while the genetic material encodes each variant resides on the inside and maintains the relatively independent spatial structure and biological activity. Studies have shown that the phage display technology can be used to screen tumor homing peptides, target transporting antisubstances, develop vaccines, research diagnostic regents and image in blood vessels. Thus phage display technology is a powerful method to overcome the challenge of tumor disease.
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    DNA methylation of glioma related gene and its significance
    Yan Xiaoguang, Hua Dingchao, Guo Geng, Lu Chenyang
    2015, 42 (10):  762-765.  doi: 10.3760/cma.j.issn.1673-422X.2015.10.012
    Abstract ( 934 )   PDF (714KB) ( 1430 )   Save
    DNA methylation is closely related to the genesis and development of glioma. The CpG islands hypermethylation in promoter region of DNA repair genes, cell cycle controlling genes, apoptosis related genes, tumor suppressor genes and invasion related genes are found in glioma. Finding the specific methylation profile and molecular marker of glioma is helpful for the pathology class, early diagnosis and prognostic evaluation. Meanwhile, DNA methylation has the characteristic of reversibility, which may provide new ways for the treatment of glioma.
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    Roles of UBE2C in breast cancer and its clinical significance
    Qin Tao, Li Man.
    2015, 42 (10):  766-768.  doi: 10.3760/cma.j.issn.1673-422X.2015.10.013
    Abstract ( 470 )   PDF (703KB) ( 1285 )   Save
    Ubiquitinconjugating enzyme 2C (UBE2C) is involved in cell cycle progression, mitosis regulation and targeted degradation of shortlived proteins. UBE2C is the cancerrelated ubiquitinconjugating enzyme, which is significantly higher in breast cancer tissues compared to the adjacent normal tissue. The abnormal expression of UBE2C participates in the process of occurrence, development and metastasis of breast cancer by the regulation of cell cycle progression, CerbB2, cell apoptosis factors and metastasis related genes. It will provide reference for the diagnosis and prognosis of breast cancer.
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    Gemcitabine in combination with chemotherapy in the treatment of recurrent or metastatic breast cancer
    Tong Zhongsheng, Xu Cong, Wang Jin
    2015, 42 (10):  769-772.  doi: 10.3760/cma.j.issn.1673-422X.2015.10.014
    Abstract ( 458 )   PDF (715KB) ( 1333 )   Save
    Gemcitabine based chemotherapy is effective in recurrent or metastatic breast cancer. Besides the 3 week regimen in combination with paclitaxel, individualized treatments are also applied to combine gemcitabine with other agents such as docetaxel or platinum, or to administer by different frequency or dose, or to continuously maintain on the treatment as an extension to front line. It is demonstrated that gemcitabine in combination with taxanes can obtain survival benefit, largely in patients with visceral metastasis or hormone receptor negative. Initial evidence has also supported the feasibility of continuous maintenance. Finally, gemcitabine in combination with cisplatin is a better option for the metastatic triple negative breast cancer.
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    Stereotactic body radiotherapy for early stage nonsmall cell lung cancer
    Lin Li, Zhou Fuxiang
    2015, 42 (10):  773-775.  doi: 10.3760/cma.j.issn.1673-422X.2015.10.015
    Abstract ( 445 )   PDF (706KB) ( 1354 )   Save
    As one of the treatment options for early stage NSCLC, stereotactic body radiation therapy (SBRT) is mainly applied to the inoperable patients. Compared with small doses of traditional fractionated radiation treatment, SBRT are taken a single high dose of radiation. A large body of experience has been accumulated over the years and the mathematical model to describe survival in high dose range typically used in SBRT and the best dose of segmentation model were focused on, but there has not yet reached a consensus. Studies show that SBRT has certain advantages in local control ratio and adverse reaction compared with traditional radiotherapy, which can be used in operable patients in the future.
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    The immunotherapy of lung cancer
    Zhang Shujuan, Chang Jianhua
    2015, 42 (10):  776-779.  doi: 10.3760/cma.j.issn.1673-422X.2015.10.016
    Abstract ( 449 )   PDF (713KB) ( 1575 )   Save
    Lung cancer is characterized by high malignancy and the majority of patients are diagnosed at the advanced or late stage. Chemoradiotherapy has insufficient effect on this malignant tumor. At present the immune therapy has become a new choice for lung cancer treatment. Ipilimumab, antibody to programmed death1, immune cells, cytokines, melanomaassociated antigen A3 vaccine, liposomal BLP25, belagenpumatucelL and polypeptide vaccine have been proved effective for lung cancer through various clinical trials. Futhermore, most of them have been moved forward to phase Ⅲ clinical trials in order to get more strong evidence to support the immunotherapy incorporated into the multidisciplinary treatment of lung cancer.
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    Research progress of microRNA in gastric cancer
    Dou Yue, Tang Yong
    2015, 42 (10):  780-782.  doi: 10.3760/cma.j.issn.1673-422X.2015.10.017
    Abstract ( 321 )   PDF (703KB) ( 1297 )   Save
    microRNAs (miRNAs) are endogenous noncoding RNAs, which play important roles in the regulation of gene terms. miRNAs affect almost every physiological process of the body, and many diseases are related to the disorders of miRNAs. Current studies show that the abnormal expressions of miRNAs are closely relate to the tumorigenesis, diagnosis, treatment and prognosis of gastric cancer. So miRNAs can be used as potential biomarkers and therapeutic targets for the gastric cancer.
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    microRNAs and recurrent hepatocellular carcinoma
    Ma Chenyang, Hu Minghua
    2015, 42 (10):  783-785.  doi: 10.3760/cma.j.issn.1673-422X.2015.10.018
    Abstract ( 312 )   PDF (706KB) ( 1149 )   Save
    microRNAs (miRNAs) play important roles in recurrent hepatocellular carcinoma by regulating translation of target gene expression. Researches show that the abnormal expressions of miRNAs are closely related to the recurrent hepatocellular carcinoma, and the mechanisms include regulation of tumor angiogenesis and proliferation of tumor cells. miRNAs may be the most potential therapeutic targets for recurrent hepatocellular carcinoma and have special advantages in prediction.
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    Anti-hepatoma mechanisms of ginsenoside
    Zhang Na, Feng Yinglu
    2015, 42 (10):  786-788.  doi: 10.3760/cma.j.issn.1673-422X.2015.10.019
    Abstract ( 455 )   PDF (705KB) ( 1536 )   Save
    Ginsenosides (GS) as the main ingredient of ginseng, include dozens of monomer, such as Rg3, Rh2, Rd, Rh1, Rg2, etc. GS and various monomers have different antihepatoma mechanisms. The main mechanism includes the following aspects， inducing the apoptosis of liver cancer cells, inhibiting the proliferation, invasion and metastasis, reversing the multidrug resistance of liver cancer cells, increasing therapeutic effects by combining with other treatments, improving the immune function of organism and inhibiting hepatic glucose production. Different GS monomers play different roles of antihepatoma through their respective channels.
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    The related factors of endometrial cancer induced by obesity
    Zhang Ying, Sheng Xiugui
    2015, 42 (10):  789-792.  doi: 10.3760/cma.j.issn.1673-422X.2015.10.020
    Abstract ( 387 )   PDF (710KB) ( 1211 )   Save
    Large amounts of clinical studies and epidemiological data have confirmed that obesity is closely related to the development and progression of endometrial cancer. The mechanism of the endometrial cancer may be involved estrogen, insulin, insulinlike growth factor, leptin, adiponectin, resistin fat factor, inflammatory factors and so on.
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    Evolution of the thematic structure of oncology based on the co-word analysis
    Cheng Xueke, Su Cheng
    2015, 42 (10):  795-800.  doi: 10.3760/cma.j.issn.1673-422X.2015.10.022
    Abstract ( 245 )   PDF (2203KB) ( 1942 )   Save
    Objective To explore the changes of the internal structure and research topics of oncology from 2005 to 2014, and offer reference for the development of the related studies and research policies. Methods The articles published in 203 journals in the area of "oncology" from 2005 to 2014 included by JCR were chosen. Firstly, we cleaned the author keywords using the TDA software. After that, we standardized and categorized the keywords according to the Medical Subject Headings (MeSH) manually. In the end, we builted the cooccurrence matrixes of highfrequency words in three stages: 2005—2007, 2008—2010 and 2011—2014, and drew the evolution maps and strategic diagrams of each stage to analyze the changes of the internal structure and research topics of oncology. Results While the word frequence increasing rapidly, the main keywords reduced gradually from 2005 to 2014. The traditional treatments such as chemotherapy and radiotherapy, the diagnostic and the epidemiological investigation were the core subject of oncology. With the screening of neoplasms, the research on the cell physiological phenomena and the genetic phenomena gained vigorous expansion. "Breast neoplasms", the topic whose deep exploration also led the development of other topics, has always been the hard nut as well as the hot topic of the oncology. During this period, researches on the screening of neoplasms and the genetic phenomena were developed rapidly. Conclusion The content of oncology will be more thoroughly with some merge, division, development, declining and perishing of the internal themes occurred as well. The boundaries among the substructure are becoming more and more blurred and the screening of neoplasms and the genetic phenomena has gradually become the dominant trend in general practices.
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