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08 September 2015, Volume 42 Issue 9 Previous Issue    Next Issue

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Clinical observation for the treatment of malignant tumor by Kanglaite injection combined low power ultrasonic cavitation SHEN Shui-Jie, ZHANG Yong-Hong 2015, 42 (8):  641.  doi: 10.3760/cma.j.issn.1673-422X.2015.09.001 Abstract ( 333 )   PDF (837KB) ( 1049 )   Save ObjectiveTo investigate the clinical curative effect and security of Kanglaite injection in combination with low power ultrasound microbubble agents (cavitation) in the treatment of vascular embolization therapy. MethodsThirtyeight patients with abdominal malignant tumor, in accordance with the random number table, were divided into two groups: treatment group (Kanglaite combined with ultrasonic cavitation, 21 cases) and control group (Kanglaite, 17 cases). Intravenous drip with Kanglaite injection for 21 days, 200 ml per day. Ultrasonic cavitation therapy treatment for three weeks, 5 days a week and once a day. Tumors size, Karnofsky score, grade of the degree of pain and blood biochemical indicator detection were measyred before and after treatment. ResultsThere was no complete remission, 4 cases with partial remission, 10 cases with stable disease in the treatment group, and the clinical benefit rate was 66.7% (14/21). There was no complete remission, 1 case with partial remission, 3 cases with stable diseasein in control group, and the clinical benefit rate was 23.5% (4/17). The treatment group was better than control group in clinical benefit rate （66.7%∶23.5%）， pain improvement （76.2%∶41.2%）， Karnofsky score［（66.67±5.77）∶（82.86±6.44）； （64.12±5.07）∶（69.41±6.59）］, and one year survival rate （57.1%∶23.5%）(χ2=7.012， P=0.008； χ2=4.821， P=0.028； t=4.575， P<0.001； χ2=4.354， P=0.037). ConclusionKanglaite injection in combination with cavitation shows higher clinical efficient, tolerated adverse recations, and significant improvement of quality of life. References | Related Articles | Metrics

A clinical study on capecitabine maintenance treatment after combination chemotherapy to the patients with recurrent and metastatic breast cancer LING Xiao-Ling, YANG Jing-Ru, CHEN Rui, YUAN Fang-Yun, LI Chun-Mei, ZHAO Da 2015, 42 (8):  644.  doi: 10.3760/cma.j.issn.1673422X.2015.09.002 Abstract ( 409 )   PDF (926KB) ( 1164 )   Save ObjectiveTo investigate the therapeutic effect, safety and its prognostic factors of capecitabine as maintenance treatment agent for prolonging the PFS of patients with recurrent and metastatic breast cancer after they received combination chemotherapy. MethodsFrom January 2011 to June 2013, 38 cases with recurrent and metastatic breast cancer were collected in the department of medical oncology of the First Hospital of Lanzhou University. All the 38 patients received NX scheme (vinorelbine combined capecitabine chemotherapy), and some patients among of them had stabile disease after chemotherapy and were administered X scheme (capecitabine, twice a day, 2 000 mg/m2 daily, withdrawal for 7 days after a consecutive intake of 14 days, 21 days as a cycle, at least 2 cycles) until disease progressed or toxicity could not be tolerated. Adverse reactions and PFS were observed and recorded. Single factor chi square test and multivariate COX proportion hazard model were used to evaluate the relationships between clinic features and RR, PFS. ResultsThe overall response rate (CR+PR) was 55.26% (21/38), clinical benefit patients rate (CR+PR+SD) was 84.2% (32/38), with 4 patients of CR (4/32), 17 patients of PR, 11 patients of SD, 6 patients of PD. Thirtytwo no progressived patients were administered capecitabine until PD. The median PFS was 10.0 months. Stratification analysis showed that patients whose Karnofsky (KPS)≥80 had an average PFS of 14.1 months, while an average PFS of 6.8 months for patients whose KPS<80, with a statistical significance (χ2 =6.251, P=0.000). Cox proportion hazard model also showed that age (RR=3.561, 95%CI：1.3725.216, χ2=4.025, P=0.031), menopausal status (RR=1.895, 95%CI：1.1244.452, χ2=5.725, P=0.048), KPS score (RR=4.553, 95%CI：1.1317.703, χ2=11.205, P=0.005), the number of metastasis (RR=5.781, 95%CI：2.321～11.243, χ2=3.925, P=0.011) were important prognostic factors for the patients with breast cancer. Major treatmentrelated adverse reaction was grade ⅠⅡ handfoot syndrome. One patient discontinued treatment because of grade Ⅲ handfoot syndrome. ConclusionCapecitabine as maintenance treatment can significantly prolong the PFS of patients with recurrent and metastatic breast cancers at remission or stable stage after combination chemotherapy with a better tolerance. Age of patients, menopausal status, KPS score, the number of metastasis are the prognostic factors for the efficacy of NXX regimen. References | Related Articles | Metrics

The clinical significance research between leptin, estrogen, estrogen receptor and lung adenocarcinoma GUO Jia-Yi, ZHANG Long-Zhen, YANG Cheng-Xi 2015, 42 (8):  649.  doi: 10.3760/cma.j.issn.1673422X.2015.09.003 Abstract ( 467 )   PDF (791KB) ( 1236 )   Save ObjectiveTo study the expressions and significances of leptin, estrogen and estrogen receptor (ER) in pulmonary squamous carcinoma and adenocarcinoma. MethodsThe expressions of leptin and estrogen receptor were detected in 58 cases of lung adenocarcinoma and 63 cases of pulmonary squamous cell carcinoma and 50 cases of normal lung tissue samples by immunohistochemical menthod, the levels of estrogen were also detected in patients with venous blood at the same time. Comparison of differential expression of leptin, estrogen and estrogen receptor in lung adenocarcinoma and lung squamous cell carcinoma, normal tissues, and explore their relationships with lung adenocarcinoma. ResultsLeptin, estrogen and estrogen receptor positive rates in lung adenocarcinoma group were 65.5%, 36.2% and 58.6% respectively, and 33.3%, 15.9%, 30.2% in lung squamous cell carcinoma group. There were a statistical difference between the two groups (χ2=4.324, P<0.050; χ2=5.372, P<0.050; χ2=5.718, P<0.050). In the normal control group the positive rates were 24.0%, 4.0% and 0 respectively, and there was a statistical difference compared with lung adenocarcinoma group (χ2=7.126, P<0.010; χ2=9.683, P<0.005; χ2=22.308, P<0.005). In lung adenocarcinoma group, leptin, estrogen and estrogen receptor positive rate have no relationships with tumor stage (χ2=0.001, P=0.950; χ2=0.061, P=0.900; χ2=0.178, P=0.750) and primary tumor size (χ2=0.023, P=0.900; χ2=0.001, P=0.950; χ2=0.001, P=0.950). ConclusionLeptin, estrogen and ER were expressed highly in adenocarcinoma of lung tumor. The expressions of leptin, estrogen and ER may associated with the carcinogenesis, development and clinical type of adenocarcinoma of lung. References | Related Articles | Metrics

The value of peripheral blood circulating tumor cells in KRAS mutation testing of colorectal cancer patients LIU Yan-Kui, WANG Xiao-Li, JIN Lin-Fang, QI Xiao-Wei 2015, 42 (8):  653.  doi: 10.3760/cma.j.issn.1673422X.2015.09.004 Abstract ( 431 )   PDF (765KB) ( 1456 )   Save ObjectiveTo explore the value of peripheral blood samples in KRAS mutation testing of colorectal cancer patients and the correlation between the number of circulating tumor cells and KRAS mutation testing. MethodsWe detected KRAS mutation using amplification refractory mutation system PCR method in paraffin embedded tissues and matched peripheral blood samples obtained from 112 colorectal cancer patients and 10 proctitic peripheral blood samples in Affiliated Hospital of Jiangnan University between 2013 and 2014. Meanwhile, immunofluorescence in situ hybridization method was used to count the circulating tumor cells in peripheral blood samples and proctitic control samples. ResultsAmong the 112 colorectal cancer samples tested, 25 cases of peripheral blood samples found KRAS mutation （41.1%） and which was 46 in formalin fixed paraffin embedded tissues testing （22.3%）， with a significant difference (χ2=40.12，P<0.001). One case with KRAS wild type in formalin fixed paraffin embedded tissues was mutation type in peripheral samples. In another case, mutation site was different in different kinds of samples. The sensibility of KRAS mutation testing was 73.3%, 41.9% and 16.7% when the number of circulating tumor cells was more than 15, 5 to 15, and 1 to 5, respectively, with significant differences (χ2=23.70, P<0.001). No KRAS mutation and no circulating tumor cells were found in 10 proctitic control samples. ConclusionWe find high specificity in KRAS mutation testing of peripheral blood samples. but the accurate rate is not satisfying. KRAS mutation testing in peripheral blood samples may be an optional choice to test KRAS mutations for colorectal cancer patients who were not subjected to surgery. The sensibility of KRAS mutation testing in peripheral blood samples has a corretion with the number of circulating tumor cells. References | Related Articles | Metrics

Value of serum HE4, CYFRA21-1, CA199 in the diagnosis of ovarian benign and malignant tumor LENG Li-Li, GU Mei-Hua 2015, 42 (8):  657.  doi: 10.3760/cma.j.issn.1673422X.2015.09.005 Abstract ( 692 )   PDF (765KB) ( 1328 )   Save ObjectiveTo investigate the diagnosis significance of human epididymis （HE4）, cytokeratin19fragment （CYFRA211), carbohydrate antigen 199 (CA199) on the malignant ovarian tumor, and to evaluate the value of individual and combined detection in judging high risk ovarian cancer. MethodsThe serum HE4, CYFRA211, CA199 levels of 45 patients with primary ovarian cancer, 56 patients with benign ovarian tumor and 50 healthy checkup women in our hospital were detected by electrochemiluminescence immunoassay (ECL).The positive rates and coincidence rates of them were analyzed and the diagnostic value of them were compared.ResultsHE4 and CYFRA211 levels of ovarian cancer group were significantly higher compared with the benign tumor group and healthy control group and the differences were statistically significant (Z=-8.61，P＜0.001；Z=-8.39，P＜0.001; Z=-8.60，P＜0.001；Z=-8.39，P＜0.001)， however there is no difference between benign tumor group andcontrol group(Z=-1.31，P=0.189; Z=-1.29，P=0.191). The difference of CA199 between benign tumor group and control group was statistically significant (Z=-8.79，P＜0.001).For the malignant tumors， the specificity and positive predictive value of HE4 (99.8%, 99.7%), CYFRA211 (99.0%, 96.7%) were very high and the diagnostic accordance rates were relatively high (93.4%, 88.7%), but the sensibilities of them were lower compared with CA199.CA199 was increased both in benign and malignant ovarian tumors with different degrees， but the specificity was not very high (85.8%), and the positive predictive value and the diagnosis accordance rate were low (70.6%, 84.1%). The combined detection of HE4， CYFRA 211 and CA199 could improve the sensitivity and of the diagnosis of ovarian cancer (100%) and accuracy (89.4%).ConclusionsHE4 and CYFRA211 only increas in malignant ovarian tumors, and they are mainly used for the diagnosis of ovarian cancer; CA199 level is increased both in benign and malignant ovarian tumors, but the extent is different and it can be used for distinguishing and diagnosing of benign and malignant ovarian tumors. Combining the three indexes can improve the sensitivity and accuracy of the diagnosis of ovarian cancer, and has an important significance for the early diagnosis and treatment of ovarian cancer. References | Related Articles | Metrics

Inhibition of RPMI8226 myeloma cell xenografted tumor angiogenesis by downregulation of Notch1 LI Chun-Pu, WANG Jing, LIU Yan, WANG Ling, LI Ban-Ban, ZHANG Kai-Gang, GUO Dong-Mei 2015, 42 (8):  661.  doi: 10.3760/cma.j.issn.1673422X.2015.09.006 Abstract ( 417 )   PDF (1730KB) ( 1579 )   Save ObjectiveTo investigate the effects of Notch1 siRNA on VEGF and angiogenesis of myeloma cell line RPMI8226 in vitro and in vivo. MethodsIn vitro, Notch siRNA was transfected into RPMI8226 cells, and then cell supernatant VEGF secretion was detected using ELISA method. Expression levels of Notch1 and VEGF proteins were assayed by Western blotting. RPMI8226 cells were subcutaneously transplanted in NOD/SCID mice, and then the tumor mice were divided into three groups randomly: NS group (Notch1 siRNAtransfected group), CS group (Control siRNAtransfected group) and UN group (Untransfected group), and the changes of tumor volume were observed. Immunohistochemical staining was used to detect the changes in expression levels of Notch1, VEGF and CD34. ResultsNotch1 and VEGF proteins expressions of RPMI8226 cells were significantly decreased by Notch1 siRNA. At 48 h and 72 h, VEGF secretion level in NS group was significantly different with CS group ［（120±25）ng/L∶（175±15）ng/L, t＝3.27, P＜0.05; （145±24）ng/L∶（295±17）ng/L, t＝8.83, P＜0.01］. At 13 d, 17 d and 21 d, tumor volume in NS group was significantly reduced, that was significantly different with CS group ［（1 548±218）mm3∶（1 820±64）mm3, t＝2.68, P＜0.05; （1 200±75）mm3∶（2 180±84）mm3, t＝19.46, P＜0.01; （1 150±88）mm3∶（2 250±145）mm3, t＝14.50, P＜0.01］. The expression levels of Notch1 and VEGF protein were decreased by Notch1 siRNA. The expression levels of Notchl and VEGF in NS group were different with CS group ［（16.33±2.52）%∶（75.33±2.52）%, t＝28.71, P＜0.01; （5.00±1.00）%∶29.67±2.08 %, t＝18.50, P＜0.01］. Notch1 siRNA reduced the number of transplanted tumor neovascularization in NS group. Microvascular density in NS group was significantly less than that in CS group ［(14.67±2.52)∶(30.00±5.00), t＝4.74, P＜0.01］. ConclusionIn vitro, Notch siRNA reduces human myeloma cell RPMI8226 cell supernatant VEGF secretion. In vivo, Notch siRNA can reduce tumor volume and the number of new blood vessels in transplantedmultiple myeloma mice. Thus, Notch1 is an effective molecular target for antiangiogenesis in myeloma. References | Related Articles | Metrics

The use of omentoplasty after esophagectomy for esophageal cancer preventing complications: a metaanalysis LIN Rui-Jiang, HU Wen-Teng, MA Min-Jie, WEI Ning, HAN Biao 2015, 42 (8):  666.  doi: 10.3760/cma.j.issn.1673422X.2015.09.007 Abstract ( 383 )   PDF (1696KB) ( 1184 )   Save ObjectiveTo evaluate the length of hospital stay and the incidences of complications after omentoplasty with nonomentoplasty for the patients with esophageal cancer. MethodsThe databases including Pubmed, Embase, The Cochrane Library, Web of Science, CBM, CNKI, VIP and Wanfang data were searched for collecting randomized controlled trials on the omentoplasty. According to the inclusive and exclusive criteria, the datas were extracted. Two reviewers independently screened literatures and assessed the qualities of the included studies and extracted data. Metaanalysis was performed by using of RevMan 5.2 software. ResultsA total of 6 RCTs including 2 167 patients from 206 original articles were included in this analysis. In terms of the anastomotic leakage after esophagectomy and the hospital stays, the incidence of anastomotic leakage (OR=0.19, 95%CI: 0.09～0.39, Z=4.55, P＜0.000 01) and hospital stays (MD=-1.91, 95%CI:-2.26-1.57, Z=10.87, P＜0.000 01) with omentoplasty was significantly lower than those of the nonomentoplasty, with significant differences. However, in terms of anastomotic stricture (OR=0.76，95%CI: 0.292.01, Z=0.55, P=0.58) and mortality rate (OR=0.72, 95%CI: 0.242.21, Z=0.57, P=0.57), there wrer no significant differences. ConclusionComparing with nonomentoplasty, the use of omentoplasty has beneficial effects for the postoperative complication such as anastomotic leakage and hospital stays, and does not increase the incidence of anastomotic stricture and mortality rate. References | Related Articles | Metrics

Functional mechanism of the mutual regulation between long noncoding RNAs and other epigenetic mechanisms in cancer DANG Yi-Ni, ZHANG Guo-Xin 2015, 42 (8):  671.  doi: 10.3760/cma.j.issn.1673422X.2015.09.008 Abstract ( 283 )   PDF (794KB) ( 1425 )   Save Abnormal expressions of long noncoding RNAs (LncRNAs) are associated with a variety of tumors. Recent studies show that lncRNA can regulate other epigenetic processes such as DNA methylation, histone modifications, chromatin remodeling and miRNA through various ways； on the other side, other epigenetic processes can influence the expression of lncRNA. The mutual regulation of them paly important roles in the occurrence and development of malignant tumors. The better understanding of the crosstalk between lncRNA and epigenetic modulation will contribute to clearly clarify the mechanism of tumor, which provides a theoretical basis for the anticancer therapies targeting lncRNAs. References | Related Articles | Metrics

Mechanism of tumor dormancy LIU Jing-Wen, LIU Hong-Li 2015, 42 (8):  675.  doi: 10.3760/cma.j.issn.1673422X.2015.09.009 Abstract ( 451 )   PDF (766KB) ( 1693 )   Save Tumor dormancy is a phase of occurrence and progress of cancer. In recent years, with the further study of circulating tumor cells, disseminated tumor cells and cancer stem cells, it is found that they are closely related to the tumor dormancy. Moreover, tumor microenvironment is another important factor in tumor dormancy. References | Related Articles | Metrics

The expression and role of CMTM family in tumor ZHOU Ya-Bo, JIANG Ye, PANG Bing-Xin, WU Qian-Qian, LU Jia, HU Jie, LIU Wei 2015, 42 (8):  679.  doi: 10.3760/cma.j.issn.1673422X.2015.09.010 Abstract ( 328 )   PDF (760KB) ( 1311 )   Save CMTM family is silenced and downregulated in several kinds of tumors. Its aberrant expression has a strong association with the development, progression and metastasis of tumors. Thus, CMTM family is potential tumor suppressor genes. Epigenetics mechanism is the essential mechanism of the aberrant expression in this gene family. The discovery of this research gives a new direction to the clinical treatment of tumor. References | Related Articles | Metrics

Anticancer mechanism of scutellarin ZHANG Shao-Hua, LU Dan 2015, 42 (8):  682.  doi: 10.3760/cma.j.issn.1673422X.2015.09.011 Abstract ( 344 )   PDF (760KB) ( 1584 )   Save Scutellarin (SC), a botanical extract, possesses a variety of suppressing free radical generation, antiinflammatory, cardioprotection and antivirus activity. Recently, many studies show that SC has inhibitory effects on the growth of many tumors and is a kind of potential antitumor drug. Its antitumor mechanisms mainly include inducing apoptosis, arresting cell cycle, enhancing the adhesion between cells, inhibiting tumor invasion, reversing multidrug resistance, anti-angiogenesis and so on. References | Related Articles | Metrics

Properties of magnetic nanoparticles and its application in tumor magnetic targeting hyperthermia and challenges LIU Li-Kun, AO Bi-Feng, DING Wen-Jin, 欧Yang-Wei-Wei 2015, 42 (8):  685.  doi: 10.3760/cma.j.issn.1673422X.2015.09.012 Abstract ( 348 )   PDF (767KB) ( 1479 )   Save Magnetic nanoparticle application in the biological sciences and medicine get rapid development over the past decades. In the current cancer therapy, hyperthermia has become a new treatment method after surgical therapy, radiotherapy, chemotherapy and biological therapy. With the advent of magnetic nanoparticles, magnetic targeting hyperthermia has provided a new method for tumor hyperthermia, and has a broad development prospects. References | Related Articles | Metrics

Research progress in radiotherapy for head and neck tumors in parotid gland protection LIU Juan, MA Dai-Yuan 2015, 42 (8):  689.  doi: 10.3760/cma.j.issn.1673422X.2015.09.013 Abstract ( 396 )   PDF (767KB) ( 1172 )   Save Radiotherapy is the main treatment for head and neck cancer, but it will result in adjacent tissue damage,including radioactive xerostomia,the most common complication.The mechanism of radiationinduced parotid damage injury is unclear. Parotid function test include detection of parotid salivary flow and salivary flow rate, parotid SPECT, CT and MRI, etc.How to protect the parotid glands becomes a hot research in recent years.At present,the main methods of protecting the parotid glands includes selecting patterns of radiotherapy,radiotherapy planning optimization,drugs，stem cell transplantation and gene transduction. References | Related Articles | Metrics

Circulating microRNA in lung cancer QU Li-Li, LIU Xiao-Qing 2015, 42 (8):  693.  doi: 10.3760/cma.j.issn.1673422X.2015.09.014 Abstract ( 241 )   PDF (759KB) ( 1346 )   Save MicroRNAs (miRNAs) negatively mediate the post transcriptional target genes by degrading mRNAs and inhibiting translation of protein. Deregulation of miRNAs are directly or indirectly correlated with tumorigenesis and development of cancer. Currently, the application of miRNAs as a noninvasive potential biomarker with high stability is under investigation. References | Related Articles | Metrics

Research progress of narrow band imaging in the diagnosis of early esophageal cancer SONG Lai, PENG Xiao-Dong, YANG Xiao-Hong, FU Mao-Yong 2015, 42 (8):  696.  doi: 10.3760/cma.j.issn.1673422X.2015.09.015 Abstract ( 287 )   PDF (760KB) ( 1296 )   Save Early diagnosis of esophageal cancer is essential for improving both the effectiveness of esophageal cancer treatment and the prognosis of patients. As a new technology for esophageal cancer early diagnosis，narrowband imaging (NBI) enables surgeon to clearly observe the mucosa and submucosal blood vessels changes in early esophageal cancer. It has initially shown excellent application value in the early diagnosis.In particular it has obvious advantages to the ordinary white light endoscopy which is currently used in esophageal cancer early diagnosis. If combined with Lugol iodine staining ,magnifying endoscopy and other diagnostic methods in clinical, NBI will have a better value in early diagnosis of esophageal. References | Related Articles | Metrics

Application of minimally invasive esophagectomy in the treatment of surgical procedure for esophageal cancer WU Han-Ran, JIE Ming-Ran, LIU Chang-Qing, SUN Xiao-Hui, GUO Ming-Fa, XU Mei-Qing 2015, 42 (8):  699.  doi: 10.3760/cma.j.issn.1673422X.2015.09.016 Abstract ( 385 )   PDF (758KB) ( 1246 )   Save Recently, the main treatment for esophageal cancer remains curative resection combined with adjuvant chemoradiotherapy. With the application of minimally invasive esophagectomy (MIE) in the surgical treatment in recent years, patients with esophageal cancer who received MIE are proved to have less postoperative complications, better quality of life, and better surgical effect. However, different operation methods of MIE have different advantages and disadvantages, that makes the clinical promotion of MIE need further clinical experience, surgical techniques and procedures. The longterm effect of MIE remains to be further verification. References | Related Articles | Metrics

Research advances on the significance of FOXA1 in breast cancer LUO Xiang-Rong, WEI Xiao-Long, CHEN Wei-Ling, ZHANG Guo-Jun 2015, 42 (8):  702.  doi: 10.3760/cma.j.issn.1673422X.2015.09.017 Abstract ( 340 )   PDF (767KB) ( 1571 )   Save Forkhead box A1 (FOXA1) is expressed in various organs, including breast, liver, pancreas, bladder, prostate, colon, ovary, lung and esophagus. The FOXA1 expression is associated with the growth and carcinogenesis of these organs. It is recently demonstrated FOXA1 plays a significant role in different biological processes including cell proliferation,differentiation,devolopment,carcinogenesis and the process of epithelialmesenchymal transition (EMT)etc. Its expression is positively correlated with ER and PR expression, and it is demonstrate to be one of the most important favorate prognostic factors of breast cancer. References | Related Articles | Metrics

The plasma riboflavin level and gastric cancer MU Ai-Tai-尔·Mai-Ti-Nu-Ri, MA Yi-Nu-尔·Ai-Li 2015, 42 (8):  706.  doi: 10.3760/cma.j.issn.1673422X.2015.09.018 Abstract ( 387 )   PDF (766KB) ( 1098 )   Save Gastric cancer incidence and morality are high, and its comprehensive treatment of gastric cancer has a major significance in clinical. Riboflavin is a watersoluble vitamin, absorbed by riboflavin transporter protein, which can perform antitumor function by inhibiting tumor cell prolifiration and inducing promoting apoptosis. Riboflavin plays importan roles in gastric cancer development, treatment, cancer invasion, metastasis and reducing the adverse effects of chemotherapy. Studying on mechanism and biological characterristic of riboflavin may help to develop more specific individualized treatment plans for the patients with gastric cancer in the future. References | Related Articles | Metrics

Biomarkers of colorectal cancer in individual therapy ZHANG Yi-Fan, YIN Hai-Tao 2015, 42 (8):  710.  doi: 10.3760/cma.j.issn.1673422X.2015.09.019 Abstract ( 288 )   PDF (762KB) ( 1150 )   Save In the field of colorectal cancer molecular biology, there are a number of biomarkers of prognosis and curative effect, including orotate phosphoribosyltransferase, P53, thymidylate synthase, glutathione Stransferase, methylenetetrahydrofolate reductase, dihydropyfimidine dehydrogenase, uridinediphosphoglucuronosyl transferase, which can select the effective patients or the patients who can′t bear the side effects and contribute to the individualized treatment of colorectal cancer. References | Related Articles | Metrics