Journal of International Oncology ›› 2015, Vol. 42 ›› Issue (10): 747-749.doi: 10.3760/cma.j.issn.1673-422X.2015.10.007

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Expression and significance of HA117 gene in tumor

Wang Hong, Jia Xiuhong   

  1. Department of Pediatrics, Affiliated Hospital of Binzhou Medical University, Binzhou 256603, China
  • Online:2015-10-08 Published:2015-09-08
  • Contact: Jia Xiuhong E-mail:jiaxiuhong001@163.com

Abstract: HA117, as a multiple drug resistance(MDR) gene, has recently been discovered. It may mediate the MDR of tumor through Bcl2 antiapoptotic pathways. HA117 gene exists high expression in leukemia, lymphoma, breast cancer, neuroblastoma, colon adenocarcinoma and so on, and its overexpression is closely associated with the MDR and poor prognosis of these tumors.

Key words: Neoplasms, HA117 gene