Progress of phage display technology in cancer

doi:10.3760/cma.j.issn.1673-422X.2015.10.011

Abstract

Abstract: Phage display technology describes a genetic engineering technique in which a library of peptide or protein variants is expressed on the outside of a phage virion, while the genetic material encodes each variant resides on the inside and maintains the relatively independent spatial structure and biological activity. Studies have shown that the phage display technology can be used to screen tumor homing peptides, target transporting antisubstances, develop vaccines, research diagnostic regents and image in blood vessels. Thus phage display technology is a powerful method to overcome the challenge of tumor disease.

Key words: Neoplasms, Phage display technology

Luo Junqian, Dong Suming, Zhang Fan, Yang Xiaofeng. Progress of phage display technology in cancer[J]. Journal of International Oncology, 2015, 42(10): 759-761.

References

［1］陈记稷, 胡智渊, 张彦琼, 等. 肿瘤血管靶向噬菌体展示肽的研究进展［J］. 医学分子生物学杂志, 2006, 3(2): 149-152. ［2］ Deutscher SL. Phage display in molecular imaging and diagnosis of cancer［J］. Chem Rev, 2010, 110(5): 3196-3211. ［3］ Lee TY, Lin CT, Kuo SY, et al. Peptidemediated targeting to tumor blood vessels of lung cancer for drug delivery［J］. Cancer Res, 2007, 67(22): 10958-10965. ［4］ Li Y, Lei Y, Wagner E, et al. Potent retroinverso D-peptide for simultaneous targeting of angiogenic blood vasculature and tumor cells［J］. Bioconjug Chem, 2013, 24(1): 133-143. ［5］ Zhi M, Wu KC, Hao ZM, et al. Screening of specific binding peptide targeting blood vessel of human esophageal cancer in vivo in mice［J］. Chin Med J (Engl), 2011, 124(4): 581-585. ［6］ Xiao M, Hong Z, Sun L, et al. TMTP1, a novel tumorhoming peptide, specifically targets hematological malignancies and their metastases［J］. J Huazhong Univ Sci Technolog Med Sci, 2011, 31(5): 608-613. ［7］ Lowery A, Onishko H, Hallahan DE, et al. Tumortargeted delivery of liposomeencapsulated doxorubicin by use of a peptide that selectively binds to irradiated tumors［J］. J Control Release, 2011, 150(1): 117-124. ［8］ Potala S, Verma RS. Targeting head and neck squamous cell carcinoma using a novel fusion toxindiphtheria toxin/HN1［J］.Mol Biol Rep, 2011, 38(2): 1389-1397. ［9］ Arap W, Pasqualini R, Ruoslahti E. Chemotherapy targeted to tumor vasculature［J］. Curr Opin Oncol, 1998, 10(6): 560-565. ［10］ Curnis F, Sacchi A, Borgna L, et al. Enhancement of tumor necrosis factor alpha antitumor immunotherapeutic properties by targeted delivery to aminopeptidase N (CD13)［J］. Nat Biotechnol, 2000, 18(11): 1185-1190. ［11］ Essler M, Grtner FC, Neff F, et al. Therapeutic efficacy and toxicity of 225Aclabelled vs 213 Bilabelled tumourhoming peptides in a preclinical mouse model of peritoneal carcinomatosis［J］. Eur J Nucl Med Mol Imaging, 2012, 39(4): 602-612. ［12］张家禾, 左伟勇, 洪伟鸣, 等. 噬菌体展示技术及其在抗体制备中应用的研究进展［J］. 南昌大学学报:医学版, 2014, 54(2): 83-88. ［13］ Bi Q, Tan T, Xiang X, et al. Detection of breast cancer related antigens through cDNA phage displayed protein microarray［J］. Biol Chem, 2010, 391(7): 831-835. ［14］ Ye Y, Chen X. Integrin targeting for tumor optical imaging［J］. Theranostics, 2011, 1: 102-126. ［15］ Gao J, Chen K, Xie R, et al. In vivo tumortargeted fluorescence imaging using nearinfrarednearinfrared noncadmium quantum dots［J］. Bioconjug Chem, 2010, 21(4): 604-609. ［16］强荣兵, 张楠楠, 魏丽丽, 等. 噬菌体展示技术及其在肿瘤研究中的应用［J］. 中国生物工程杂志, 2009, 29(9): 81-86. ［17］ Silman NJ. World influenza congress Europe 2009［J］. Expert Rev Vaccines, 2010, 9(3): 273-275 ［18］ Bretscher MT, Althaus CL, Müller V, et al. Recombination in HIV and the evolution of drug resistance: for better or for worse?［J］. Bioessays, 2004, 26(2): 180-188. ［19］杨柳, 沈克飞, 郑华, 等. 噬菌体展示颗粒疫苗的研究进展［J］. 中国生物制品学杂志, 2013, 26(4): 569-573. ［20］刘文俊, 赵祖国, 吕世静, 等. 噬菌体展示技术在抗体亲和力成熟中的应用进展［J］. 免疫学杂志, 2012, 28(7): 628-632. ［21］黄娴. 利用噬菌体展示技术发现针对血型抗原的单链抗体［D］. 上海：华东师范大学, 2012. ［22］张自强, 杨晓峰, 刘杰昊. 肽类药物在肿瘤治疗中的研究进展［J］. 国际肿瘤学杂志, 2015, 42(1): 52-55.

[1]	Liu Na, Kou Jieli, Yang Feng, Liu Taotao, Li Danping, Han Junrui, Yang Lizhou. Clinical value of serum miR-106b-5p and miR-760 combined with low-dose spiral CT in the diagnosis of early lung cancer [J]. Journal of International Oncology, 2024, 51(6): 321-325.
[2]	Yang Mi, Bie Jun, Zhang Jiayong, Deng Jiaxiu, Tang Zuge, Lu Jun. Analysis of the efficacy and prognosis of neoadjuvant therapy for locally advanced resectable esophageal cancer [J]. Journal of International Oncology, 2024, 51(6): 332-337.
[3]	Yuan Jian, Huang Yanhua. Diagnostic value of Hp-IgG antibody combined with serum DKK1 and sB7-H3 in early gastric cancer [J]. Journal of International Oncology, 2024, 51(6): 338-343.
[4]	Chen Hongjian, Zhang Suqing. Study on the relationship between serum miR-24-3p， H2AFX and clinical pathological features and postoperative recurrence in liver cancer patients [J]. Journal of International Oncology, 2024, 51(6): 344-349.
[5]	Guo Zehao, Zhang Junwang. Role of PFDN and its subunits in tumorigenesis and tumor development [J]. Journal of International Oncology, 2024, 51(6): 350-353.
[6]	Zhang Baihong, Yue Hongyun. Advances in anti-tumor drugs with new mechanisms of action [J]. Journal of International Oncology, 2024, 51(6): 354-358.
[7]	Xu Fenglin, Wu Gang. Research progress of EBV in tumor immune microenvironment and immunotherapy of nasopharyngeal carcinoma [J]. Journal of International Oncology, 2024, 51(6): 359-363.
[8]	Wang Ying, Liu Nan, Guo Bing. Advances of antibody-drug conjugate in the therapy of metastatic breast cancer [J]. Journal of International Oncology, 2024, 51(6): 364-369.
[9]	Zhang Rui, Chu Yanliu. Research progress of colorectal cancer risk assessment models based on FIT and gut microbiota [J]. Journal of International Oncology, 2024, 51(6): 370-375.
[10]	Gao Fan, Wang Ping, Du Chao, Chu Yanliu. Research progress on intestinal flora and non-surgical treatment of the colorectal cancer [J]. Journal of International Oncology, 2024, 51(6): 376-381.
[11]	Liu Jing, Liu Qin, Huang Mei. Prognostic model construction of lung infection in patients with chemoradiotherapy for esophageal cancer based on SMOTE algorithm [J]. Journal of International Oncology, 2024, 51(5): 267-273.
[12]	Yang Lin, Lu Ning, Wen Hua, Zhang Mingxin, Zhu Lin. Study on the clinical relationship between inflammatory burden index and gastric cancer [J]. Journal of International Oncology, 2024, 51(5): 274-279.
[13]	Wang Junyi, Hong Kaibin, Ji Rongjia, Chen Dachao. Effect of cancer nodules on liver metastases after radical resection of colorectal cancer [J]. Journal of International Oncology, 2024, 51(5): 280-285.
[14]	Zhang Ningning, Yang Zhe, Tan Limei, Li Zhenning, Wang Di, Wei Yongzhi. Diagnostic value of cervical cell DNA ploidy analysis combined with B7-H4 and PKCδ for cervical cancer [J]. Journal of International Oncology, 2024, 51(5): 286-291.
[15]	Fu Yi, Ma Chenying, Zhang Lu, Zhou Juying. Research progress of habitat analysis in radiomics of malignant tumors [J]. Journal of International Oncology, 2024, 51(5): 292-297.