Journal of International Oncology ›› 2015, Vol. 42 ›› Issue (10): 750-752.doi: 10.3760/cma.j.issn.1673-422X.2015.10.008

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Mechanism of Raf kinase inhibitor protein down-regulation in cancer

Wang Yun, Li Yuhong   

  1. Department of Medical Oncology, Sun YatSen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China
  • Online:2015-10-08 Published:2015-09-08
  • Contact: Li Yuhong E-mail:liyh@sysucc.org.cn

Abstract: Raf -kinase inhibiting protein (RKIP) plays a vital role in various physiological processes and participates in multiple signaling pathways, with a close releationgship with tumor. The mechanism of RKIP down-regulation in neoplasms includes transcriptional regulation, methylation, acetylation, histone modification, microRNA regulation and NF-κB/Snail/RKIP loop regulation.

Key words: Phosphatidylethanolamine binding protein, Neoplasms, Gene expression regulation