Journal of International Oncology ›› 2021, Vol. 48 ›› Issue (4): 212-215.doi: 10.3760/cma.j.cn371439-20200722-00042

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Regulation of IL-35, IL-39 and IL-27 in tumor microenvironment

Liu Saisai, Yuan Dongya()   

  1. Key Laboratory of Molecular Mechanism and Intervention Research for Plateau Diseases of Tibet Autonomous Region, Xizang Minzu University, Xianyang 712082, China
  • Received:2020-07-22 Revised:2020-12-20 Online:2021-04-08 Published:2021-06-18
  • Contact: Yuan Dongya E-mail:dy62@163.com

Abstract:

The interleukin family can directly or indirectly stimulates the proliferation, survival and diffusion of tumor cells, and further shapes the tumor microenvironment, thus affecting the tumor growth and transformation to a certain extent. Studies show that the new numbers of IL-12 family, IL-35, IL-39 and IL-27, play the relevant specific immune functions in a variety of tumors, which may be important target molecules for tumors research.

Key words: Tumor microenvironment, Immunity, Cytokines