Regulation of mTOR singnaling pathway by microRNA in hepatocellular carcinoma

doi:10.3760/cma.j.issn.1673-422X.2019.10.012

Journal of International Oncology ›› 2019, Vol. 46 ›› Issue (10): 624-626.doi: 10.3760/cma.j.issn.1673-422X.2019.10.012

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Regulation of mTOR singnaling pathway by microRNA in hepatocellular carcinoma

Niu Yaqian, Chang Yuling, Liu Fang, Chu Huiyuan, Chen Che

College of Clinical Medicine, Gansu University of Chinese Medicine, Lanzhou 730000, China

Online:2019-10-08 Published:2019-12-22
Contact: Chen Che, Email: chen72123@163.com E-mail:chen72123@163.com
Supported by:
National Natural Science Foundation of China (81460456)

Abstract

Abstract:

MicroRNA (miRNA) is a non-coding small molecule RNA, which is involved in the occurrence and development of tumor as an oncogene or tumor suppressor gene. The abnormal expression of many kinds of miRNAs in hepatocellular carcinoma (HCC) can directly or indirectly act on PI3K, Akt, mTOR, IGF-1R, TGF-β and other signal molecules in mTOR signal pathway, they are crucial in the appreciation, invasion and metastasis of HCC cells.

Key words:

Carcinoma, hepatocellular, MicroRNAs, TOR serine-threonine kinases

Niu Yaqian, Chang Yuling, Liu Fang, Chu Huiyuan, Chen Che.

Regulation of mTOR singnaling pathway by microRNA in hepatocellular carcinoma [J]. Journal of International Oncology, 2019, 46(10): 624-626.

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Regulation of mTOR singnaling pathway by microRNA in hepatocellular carcinoma

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