Roles of microRNA in the regulation of tumor-associated macrophage polarization during the remodeling of breast cancer immune microenvironment

doi:10.3760/cma.j.cn371439-20200401-00050

Abstract

Abstract:

Tumor associated macrophage (TAM), as the main type of immune cells in tumor microenvironment, becomes an active participant in the development of breast cancer. MicroRNA (miRNA) can regulate post-transcriptional gene expression, modulation of macrophage function by affecting its polarization typing and transformation, and ultimately contribute to the occurrence and development of breast cancer. It could provide a new diagnosis and clinical treatment strategy for the treatment of breast cancer by summarizing the mechanisms of miRNA in the polarization of TAM.

Key words: Breast neoplasms, Tumor microenvironment, Macrophages, MicroRNAs

Zhou Jiamin, Ye Lisha, Wang Guohua. Roles of microRNA in the regulation of tumor-associated macrophage polarization during the remodeling of breast cancer immune microenvironment[J]. Journal of International Oncology, 2020, 47(7): 428-430.

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