Research progress on the mechanism of endocrine therapy resistance for breast cancer

doi:10.3760/cma.j.cn371439-20221123-00070

Abstract

Abstract:

Endocrine therapy resistance is a major challenge in the treatment of hormone receptor-positive breast cancer. In recent years，endocrine resistance mechanisms have focused on ESR1 mutations or fusions，epigenetic regulation，abnormal regulation of signal transduction pathway，cell cycle regulation，cancer stem cells，metabolic reprogramming，tumor microenvironment and autophagy. Exploring the latest advances in the mechanisms of endocrine therapy resistance in breast cancer may provide more research ideas and treatment options for the precision treatment of hormone receptor-positive breast cancer.

Key words: Breast neoplasms, Receptors, estrogen, Drug resistance, Endocrine therapy

Wang Wende, Zeng De. Research progress on the mechanism of endocrine therapy resistance for breast cancer[J]. Journal of International Oncology, 2023, 50(6): 352-356.

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