Role of ANGPTL4 in tumorigenesis and development

doi:10.3760/cma.j.cn371439-20221218-00069

Abstract

Abstract:

Angiopoietin-like protein 4 （ANGPTL4） is involved in the regulation of glucose and lipid metabolism and angiogenesis，and is closely related to tumorigenesis，development，invasion and metastasis. The abnormal expression of ANGPTL4 gene can promote or inhibit the growth and proliferation of tumor cells and play a tumor-promoting or anti-tumor role in the occurrence and development of tumors. To explore the role of ANGPTL4 gene in the occurrence and development of different tumors can provide reference for evaluating the diagnosis，prognosis and curative effect of tumors.

Key words: Neoplasms, Angiopoietin-like protein 4

Liu Yanying, Yang Yu. Role of ANGPTL4 in tumorigenesis and development[J]. Journal of International Oncology, 2023, 50(6): 348-351.

References 42

[1]	Fernández-Hernando C, Suárez Y. ANGPTL4: a multifunctional protein involved in metabolism and vascular homeostasis[J]. Curr Opin Hematol, 2020, 27(3): 206-213. DOI: 10.1097/MOH.0000000000000580. doi: 10.1097/MOH.0000000000000580 pmid: 32205586
[2]	Zhan W, Tian W, Zhang W, et al. ANGPTL4 attenuates palmitic acid-induced endothelial cell injury by increasing autophagy[J]. Cell Signal, 2022, 98: 110410. DOI: 10.1016/j.cellsig.2022.110410. doi: 10.1016/j.cellsig.2022.110410
[3]	Aryal B, Price NL, Suarez Y, et al. ANGPTL4 in metabolic and cardiovascular disease[J]. Trends Mol Med, 2019, 25(8): 723-734. DOI: 10.1016/j.molmed.2019.05.010. doi: S1471-4914(19)30127-3 pmid: 31235370
[4]	Fang Y, Li X, Cheng H, et al. ANGPTL4 regulates lung adenocarcinoma pyroptosis and apoptosis via NLRP3\ASC\caspase 8 signaling pathway to promote resistance to gefitinib[J]. J Oncol, 2022, 2022: 3623570. DOI: 10.1155/2022/3623570. doi: 10.1155/2022/3623570
[5]	Lin S, Miao Y, Zhang X, et al. ANGPTL4 negatively regulates the progression of osteosarcoma by remodeling branched-chain amino acid metabolism[J]. Cell Death Discov, 2022, 8(1): 225. DOI: 10.1038/s41420-022-01029-x. doi: 10.1038/s41420-022-01029-x pmid: 35461343
[6]	Yan HH, Jung KH, Lee JE, et al. ANGPTL4 accelerates KRASG12D-induced acinar to ductal metaplasia and pancreatic carcinogenesis[J]. Cancer Lett, 2021, 519: 185-198. DOI: 10.1016/j.canlet.2021.07.036. doi: 10.1016/j.canlet.2021.07.036
[7]	Hui B, Ji H, Xu Y, et al. RREB1-induced upregulation of the lncRNA AGAP2-AS1 regulates the proliferation and migration of pancreatic cancer partly through suppressing ANKRD1 and ANGPTL4[J]. Cell Death Dis, 2019, 10(3): 207. DOI: 10.1038/s41419-019-1384-9. doi: 10.1038/s41419-019-1384-9 pmid: 30814490
[8]	Kersten S. New insights into angiopoietin-like proteins in lipid metabolism and cardiovascular disease risk[J]. Curr Opin Lipidol, 2019, 30(3): 205-211. DOI: 10.1097/MOL.0000000000000600. doi: 10.1097/MOL.0000000000000600 pmid: 30893111
[9]	Hübers C, Abdul Pari AA, Grieshober D, et al. Primary tumor-derived systemic nANGPTL4 inhibits metastasis[J]. J Exp Med, 2023, 220(1): e20202595. DOI: 10.1084/jem.20202595. doi: 10.1084/jem.20202595
[10]	Aarsetøy R, Ueland T, Aukrust P, et al. Angiopoietin-2 and angiopoietin-like 4 protein provide prognostic information in patients with suspected acute coronary syndrome[J]. J Intern Med, 2021, 290(4): 894-909. DOI: 10.1111/joim.13339. doi: 10.1111/joim.13339 pmid: 34237166
[11]	Ehrlich KC, Lacey M, Ehrlich M. Tissue-specific epigenetics of atherosclerosis-related ANGPT and ANGPTL genes[J]. Epigenomics, 2019, 11(2): 169-186. DOI: 10.2217/epi-2018-0150. doi: 10.2217/epi-2018-0150 pmid: 30688091
[12]	Oteng AB, Ruppert PMM, Boutens L, et al. Characterization of ANGPTL4 function in macrophages and adipocytes using Angptl4-knockout and Angptl4-hypomorphic mice[J]. J Lipid Res, 2019, 60(10): 1741-1754. DOI: 10.1194/jlr.M094128. doi: 10.1194/jlr.M094128
[13]	Gutgsell AR, Ghodge SV, Bowers AA, et al. Mapping the sites of the lipoprotein lipase (LPL)-angiopoietin-like protein 4 (ANGPTL4) interaction provides mechanistic insight into LPL inhibition[J]. J Biol Chem, 2019, 294(8): 2678-2689. DOI: 10.1074/jbc.RA118.005932. doi: 10.1074/jbc.RA118.005932 pmid: 30591589
[14]	He Y, Yang W, Gan L, et al. Silencing HIF-1α aggravates non-alcoholic fatty liver disease in vitro through inhibiting PPAR-α/ANGPTL4 singling pathway[J]. Gastroenterol Hepatol, 2021, 44(5): 355-365. DOI: 10.1016/j.gastrohep.2020.09.014. doi: 10.1016/j.gastrohep.2020.09.014
[15]	Liu YZ, Zhang C, Jiang JF, et al. Angiopoietin-like proteins in atherosclerosis[J]. Clin Chim Acta, 2021, 521: 19-24. DOI: 10.1016/j.cca.2021.06.024. doi: 10.1016/j.cca.2021.06.024
[16]	Yang L, Wang Y, Sun R, et al. ANGPTL4 promotes the proliferation of papillary thyroid cancer via AKT pathway[J]. Onco Targets Ther, 2020, 13: 2299-2309. DOI: 10.2147/OTT.S237751. doi: 10.2147/OTT.S237751
[17]	Avalle L, Raggi L, Monteleone E, et al. STAT3 induces breast cancer growth via ANGPTL4, MMP13 and STC1 secretion by cancer associated fibroblasts[J]. Oncogene, 2022, 41(10): 1456-1467. DOI: 10.1038/s41388-021-02172-y. doi: 10.1038/s41388-021-02172-y pmid: 35042959
[18]	Li P, Zeng X, Liu Y, et al. Angiopoietin-like protein 4 is involved in manganese superoxide dismutase-mediated suppression of breast cancer cell growth[J]. Bull Exp Biol Med, 2022, 173(2): 240-245. DOI: 10.1007/s10517-022-05526-y. doi: 10.1007/s10517-022-05526-y
[19]	El-Shal AS, Zidan HE, Rashad NM, et al. Angiopoietin-like protein 3 and 4 expression 4 and their serum levels in hepatocellular carcinoma[J]. Cytokine, 2017, 96: 75-86. DOI: 10.1016/j.cyto.2017.03.006. doi: S1043-4666(17)30071-6 pmid: 28371666
[20]	Valiakou V, Eliadis P, Karamichali E, et al. Differential expression of the host lipid regulators ANGPTL-3 and ANGPTL-4 in HCV infection and treatment[J]. Int J Mol Sci, 2021, 22(15): 7961. DOI: 10.3390/ijms22157961. doi: 10.3390/ijms22157961
[21]	D'souza S, Lau KC, Coffin CS, et al. Molecular mechanisms of viral hepatitis induced hepatocellular carcinoma[J]. World J Gastroenterol, 2020, 26(38): 5759-5783. DOI: 10.3748/wjg.v26.i38.5759. doi: 10.3748/wjg.v26.i38.5759
[22]	Frenette C. Advances in hepatocellular carcinoma[J]. Clin Liver Dis, 2020, 24(4): Ⅹ;Ⅲ-ⅩⅣ. DOI: 10.1016/j.cld.2020.08.014. doi: 10.1016/j.cld.2020.08.014
[23]	Cao Y, Agarwal R, Dituri F, et al. NGS-based transcriptome profiling reveals biomarkers for companion diagnostics of the TGF-β receptor blocker galunisertib in HCC[J]. Cell Death Dis, 2017, 8(2): e2634. DOI: 10.1038/cddis.2017.44. doi: 10.1038/cddis.2017.44
[24]	Fekir K, Dubois-Pot-Schneider H, Désert R, et al. Retrodifferentiation of human tumor hepatocytes to stem cells leads to metabolic reprogramming and chemoresistance[J]. Cancer Res, 2019, 79(8): 1869-1883. DOI: 10.1158/0008-5472.CAN-18-2110. doi: 10.1158/0008-5472.CAN-18-2110 pmid: 30837223
[25]	Wan J, Wen D, Dong L, et al. Establishment of monoclonal HCC cell lines with organ site-specific tropisms[J]. BMC Cancer, 2015, 15: 678. DOI: 10.1186/s12885-015-1692-0. doi: 10.1186/s12885-015-1692-0 pmid: 26459277
[26]	Wang FT, Li XP, Pan MS, et al. Identification of the prognostic value of elevated ANGPTL4 expression in gallbladder cancer-associated fibroblasts[J]. Cancer Med, 2021, 10(17): 6035-6047. DOI: 10.1002/cam4.4150. doi: 10.1002/cam4.4150
[27]	Lin J, Peng X, Dong K, et al. Genomic characterization of co-existing neoplasia and carcinoma lesions reveals distinct evolutionary paths of gallbladder cancer[J]. Nat Commun, 2021, 12(1): 4753. DOI: 10.1038/s41467-021-25012-9. doi: 10.1038/s41467-021-25012-9 pmid: 34362903
[28]	Shen CJ, Chang KY, Lin BW, et al. Oleic acid-induced NOX4 is dependent on ANGPTL4 expression to promote human colorectal cancer metastasis[J]. Theranostics, 2020, 10(16): 7083-7099. DOI: 10.7150/thno.44744. doi: 10.7150/thno.44744
[29]	Hsieh HY, Jou YC, Tung CL, et al. Epigenetic silencing of the dual-role signal mediator, ANGPTL4 in tumor tissues and its overexpression in the urothelial carcinoma microenvironment[J]. Oncogene, 2018, 37(5): 673-686. DOI: 10.1038/onc.2017.375. doi: 10.1038/onc.2017.375 pmid: 29035390
[30]	Tsai YT, Wu AC, Yang WB, et al. ANGPTL4 induces TMZ resistance of glioblastoma by promoting cancer stemness enrichment via the EGFR/AKT/4E-BP1 cascade[J]. Int J Mol Sci, 2019, 20(22): 5625. DOI: 10.3390/ijms20225625. doi: 10.3390/ijms20225625
[31]	Hu B, Lin JZ, Yang XB, et al. Aberrant lipid metabolism in hepatocellular carcinoma cells as well as immune microenvironment: a review[J]. Cell Prolif, 2020, 53(3): e12772. DOI: 10.1111/cpr.12772. doi: 10.1111/cpr.12772
[32]	Zuo Y, Dai L, Li L, et al. ANGPTL4 regulates psoriasis via modulating hyperproliferation and inflammation of keratinocytes[J]. Front Pharmacol, 2022, 13: 850967. DOI: 10.3389/fphar.2022.850967. doi: 10.3389/fphar.2022.850967
[33]	Dash S, Aydin Y, Widmer KE, et al. Hepatocellular carcinoma mechanisms associated with chronic HCV infection and the impact of direct-acting antiviral treatment[J]. J Hepatocell Carcinoma, 2020, 7: 45-76. DOI: 10.2147/JHC.S221187. doi: 10.2147/JHC.S221187 pmid: 32346535
[34]	Jiang Q, Miao R, Wang Y, et al. ANGPTL4 inhibits granulosa cell proliferation in polycystic ovary syndrome by EGFR/JAK1/STAT3-mediated induction of p21[J]. FASEB J, 2023, 37(2): e22693. DOI: 10.1096/fj.202201246RR. doi: 10.1096/fj.202201246RR
[35]	Zhang Y, Yang X, Liu S, et al. Comprehensive analysis of potential prognostic values of ANGPTLs in colorectal cancer[J]. Genes (Basel), 2022, 13(12): 2215. DOI: 10.3390/genes13122215. doi: 10.3390/genes13122215
[36]	Cai YC, Yang H, Wang KF, et al. ANGPTL4 overexpression inhibits tumor cell adhesion and migration and predicts favorable prognosis of triple-negative breast cancer[J]. BMC Cancer, 2020, 20(1): 878. DOI: 10.1186/s12885-020-07343-w. doi: 10.1186/s12885-020-07343-w
[37]	Hirao-Suzuki M, Takayuki K, Takiguchi M, et al. Cannabidiolic acid activates the expression of the PPARβ/δ target genes in MDA-MB-231 cells[J]. Arch Biochem Biophys, 2022, 731: 109428. DOI: 10.1016/j.abb.2022.109428. doi: 10.1016/j.abb.2022.109428
[38]	Zhang H, Wei S, Ning S, et al. Evaluation of TGFβ, XPO4, elF5A2 and ANGPTL4 as biomarkers in HCC[J]. Exp Ther Med, 2013, 5(1): 119-127. DOI: 10.3892/etm.2012.750. doi: 10.3892/etm.2012.750 pmid: 23251252
[39]	Ng KT, Xu A, Cheng Q, et al. Clinical relevance and therapeutic potential of angiopoietin-like protein 4 in hepatocellular carcinoma[J]. Mol Cancer, 2014, 13: 196. DOI: 10.1186/1476-4598-13-196. doi: 10.1186/1476-4598-13-196
[40]	Vp V, Kannan A, Perumal MK. Role of adipocyte-derived extracellular vesicles during the progression of liver inflammation to hepatocellular carcinoma[J/OL]. J Cell Physiol. [2023-03-24]. https://pubmed.ncbi.nlm.nih.gov/36960683/. DOI: 10.1002/jcp.31008. doi: 10.1002/jcp.31008
[41]	Zhang K, Zhai Z, Yu S, et al. DNA methylation mediated down-regulation of ANGPTL4 promotes colorectal cancer metastasis by activating the ERK pathway[J]. J Cancer, 2021, 12(18): 5473-5485. DOI: 10.7150/jca.52338. doi: 10.7150/jca.52338 pmid: 34405010
[42]	Li J, Ma X, Chakravarti D, et al. Genetic and biological hallmarks of colorectal cancer[J]. Genes Dev, 2021, 35(11/12): 787-820. DOI: 10.1101/gad.348226.120. doi: 10.1101/gad.348226.120