Epigenetic research progress of endometrial cancer

doi:10.3760/cma.j.cn371439-20200703-00037

Abstract

Abstract:

Endometrial cancer is one of the malignant tumors of female reproductive system. The prognosis of advanced endometrial cancer is poor. How to improve the overall survival rate and improve the prognosis of patients with advanced endometrial cancer is still one of the clinical problems. In recent years, the research on tumor gene changes is increasing gradually. Epigenetics is the study of genetic changes in gene expression without changing the nucleotide sequence of genes. Epigenetics includes many phenomena, such as DNA methylation, microRNA expression and gene silencing, chromatin remodeling. These changes may be important factors in the occurrence and development of tumors, and may become new therapeutic targets for tumors. With the study on epigenetics of endometrial cancer in the future, new therapeutic targets may be found. Meanwhile, those study may provide new ideas for targeted therapy of endometrial cancer.

Key words: Endometrial neoplasms, DNA methylation, MicroRNAs

Deng Bo'er, Kong Weimin. Epigenetic research progress of endometrial cancer[J]. Journal of International Oncology, 2021, 48(3): 184-188.

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