Immunotherapy for endometrial carcinoma based on molecular typing

doi:10.3760/cma.j.cn371439-20220408-00138

Abstract

Abstract:

Endometrial cancer has been identified by The Cancer Genome Atlas program with four molecular subtypes by genome sequence analysis. Clinical trials to select suitable immunotherapeutic agents based on the different immune characteristics of each subtype have been conducted in several countries and have made important progress. The main clinical applications of immune checkpoint inhibitors include anti-programmed cell death protein-1/programmed death-ligand 1 antibodies and poly ADP-ribose polymerase inhibitors. Optimizing drug selection and drug combination based on the target characteristics of different immune checkpoint inhibitors may provide new opportunities for immunotherapy of endometrial cancer and bring new light to improve survival rates.

Key words: Endometrial neoplasms, Molecular typing, Immunotherapy, Immune checkpoint inhibitors, Survival rate

Xu Qiuyue, Ma Xianmei, Yue Qi. Immunotherapy for endometrial carcinoma based on molecular typing[J]. Journal of International Oncology, 2022, 49(11): 700-704.

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