Abstract: ObjectiveTo assess the efficacy and safety of radiotherapy combined with sodium glycididazole (CMNa) in treating nasopharyngeal carcinoma by conducting a Metaanalysis. MethodsRandomized clinical controlled studies (RCTs) of radiotherapy plus CMNa versus radiotherapy alone in the treatment of nasopharyngeal carcinoma were retrieved from China Biology Medicine disc, China National Knowledge Infrastructure, digital journal of Wanfang Data, China Science and Technology Journal Database, PubMed and Cochrane Library. According to the inclusion and exclusion criteria, data extraction and quality assessment were done by two researchers independently, and clinically important measures were selected. Outcomes were pooled with RevMan 5.2. ResultsThe rate of complete remission (CR) in the radiotherapy combined CMNa group was better than that in the radiotherapy alone group in 1.41 multiple to primary lesion, RR=1.41, 95%CI: 1.301.52, Z=8.20, P=0.00. To lymphonodi cervicales metastasis, the rate of CR in the radiotherapy combined CMNa group was better than that in the radiotherapy alone group in 1.45 multiple, RR=1.45, 95%CI: 1.301.62, Z=6.50, P=0.00. There were no significant differences in the incidence rates of adverse reactions of skin (RR=0.97, 95%CI: 0.871.08, Z= 0.57, P=0.57 ),  mucosa (RR=1.03, 95%CI: 0.931.15, Z=0.65, P=0.52 ) and decrease in white blood cells (RR=0.84, 95%CI: 0.561.25, Z=0.87, P=0.38). ConclusionIn the treatments of nasopharyngeal carcinoma, the rates of CR of primary lesion and lymphonodi cervicales metastasis in radiotherapy combined with CMNa group are superior to the radiotherapy alone group. However, the occurrence rates of adverse reactions in the two groups have no obvious differences.

Key words: Nasopharyngeal neoplasms, Radiotherapy, Metaanalysis, Sodium glycididazole