Abstract: MicroRNA-495 (miR-495) is abnormally expressed in many tumors, especially in glioma. It involves in the proliferation, apoptosis, cycle regulation, metabolism, invasion and metastasis of tumor cells by regulating cyclin dependent kinase 6 signaling pathway, glucose transporter type 1 signaling pathway, MYB signaling pathway, growth factor independent 1 signaling pathway and high mobility group nucleosome binding domain 5 signaling pathway. Further study of miRNA-495 might provide a novel direction for clarifying the pathogenesis, diagnosis and treatment of glioma.

Key words: MicroRNAs, Glioma, Signal transduction