Mechanism of Breg cell in tumor immune escape and related therapeutic targets

doi:10.3760/cma.j.cn371439-20240522-00016

Abstract

Abstract:

Tumor cells can escape the surveillance and attack of the immune system， namely immune escape. In recent years， regulatory B （Breg） cell have attracted much attention in researches about tumor immunity. Breg cell plays an important role in tumor immune escape by secreted various cytokines. Mechanistic progress has been made in this field， which provides more targets and ideas for tumor clinical treatment. However， the phenotypic classification of Breg cells and its complex mechanism in tumor immunity still need to be systematically analyzed.

Key words: B-lymphocytes, regulatory, Tumor microenvironment, Cytokines, T-lymphocytes, Immunotherapy

Wang Xibo, Tian Baowen, Chen Shiqiao. Mechanism of Breg cell in tumor immune escape and related therapeutic targets[J]. Journal of International Oncology, 2025, 52(2): 107-112.

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