Research progress of peripheral blood biomarkers in immunotherapy of non-small cell lung cancer

doi:10.3760/cma.j.cn371439-20250110-00028

Abstract

Abstract:

Immunotherapy has achieved relatively satisfactory results in the treatment of non-small cell lung cancer （NSCLC），but not all patients can benefit from immunotherapy. Peripheral blood-based markers are easily accessible and can be monitored dynamically. Peripheral blood tumor cell-related markers （circulating tumor DNA，circulating tumor cells，peripheral blood tumor mutation load，exosomes，etc.），as well as immune and inflammatory markers （T-lymphocyte subpopulations，hematology-associated ratios，C-reactive protein，etc.） have demonstrated great potential in immunotherapy efficacy prediction，prognosis evaluation，and dynamic monitoring.

Key words: Carcinoma, non-small-cell lung, Biomarkers, tumor, Immunotherapy

Wang Zhiying, Sheng Lijun. Research progress of peripheral blood biomarkers in immunotherapy of non-small cell lung cancer[J]. Journal of International Oncology, 2025, 52(3): 180-185.

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